Sentences with phrase «avian hemagglutinin»

Not exact matches

(These proteins serve as the basis for influenza nomenclature; for instance, the H5N1 virus refers to specific classes of hemagglutinin and neuraminidase, which in this example correspond to an avian flu subtype.)

Kawaoka says he believes that the board's revised decision was influenced by a better understanding of the public - health implications of the work, which described the changes in a key viral protein called hemagglutinin that could make avian flu more transmissible among mammals.

Using virus histochemical analysis, the investigators looked at the pattern of attachment of two genetically engineered emerging H7 viruses (containing the hemagglutinin (HA) of either influenza virus A / Shanghai / 1 / 13 or A / Anhui / 1 / 13) to fixed human respiratory tract tissues and compared the findings to attachment patterns seen with human influenza viruses with high transmissibility but low virulence (seasonal H3N2 and pandemic H1N1) and highly pathogenic avian influenza (HPAI) viruses with low transmissibility and high virulence (H5N1 and H7N7).

Kawaoka, in contrast, stitched the hemagglutinin gene from the avian virus — the H5 — into a H1N1 virus that easily spreads between humans and caused the relatively mild 2009 pandemic.

This image from the work shows the binding of avian - like glycan receptors (yellow spheres) to the 2013 H7N9 influenza virus hemagglutinin (in ribbon diagram).

Paulson's team — including postdoctoral fellows Robert P. de Vries and Corwin M. Nycholat and Research Assistant Ryan McBride — tested the ability of the virus's hemagglutinin (HA) protein, to bind to different human and avian receptor variants.

But Tompkins warns that repeated vaccinations with distinct hemagglutinins would probably be needed to protect birds from the many strains of avian influenza virus.

The gene, called H5, is one of 16 subtypes of hemagglutinin, a protein that binds the avian influenza virus to the cells it infects.

Immunochemist Wayne Marasco of Harvard Medical School in Boston and colleagues discovered an unchanging part of hemagglutinin that might provide a better target when they were looking for antibodies that neutralize the avian flu.

Microbiologist Peter Palese from Mount Sinai Medical School in New York City led the second team, which added the avian flu H7, another hemagglutinin subtype, to a weakened strain of the Newcastle vaccine.

Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha - Helix Structure in Its Cleavage Site with Inefficient HA1 / HA2 Cleavage