Sentences with phrase «avoided at all costs in»

It could also be relevant to clinical applications — it treats sequence uniqueness as a high priority and thus minimises the risk of potentially unwanted gene modifications, which must be avoided at all costs in gene therapy,» says Graf.

It seems appropriate that both the word test and quiz have four letters because they do seem to be words we avoid at all cost in education today.

Railroad crossings were things to be avoided at all costs in the last Mustang — not so in this car.

Contencious issues had to be avoided at all costs in order to recover the not inconsiderable funding.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The feedback loop of the city making itself attractive to start - ups and start - ups helping to make the city attractive to talented young people (who in turn create more businesses that attract more young people) is only getting started, but Robinson says he can already see the effects both in terms of the area's legitimacy — «people are saying, «hey, I would actually invest here or I would start my business here» as opposed to 10 years ago where people would avoid the city at all costs» — and quality of life for young people.

In 2011, Deluce cut the ribbon on a shiny new 10-gate terminal at a cost of $ 50 million, one that avoids the conveyor - belted people - processor feel endemic to airports.

In 2015, make it a point to not only avoid bullying at all costs, but call out bullying by others as unacceptable.

Without a doubt, there are a bunch of places in this bizarre grove of the web that people should avoid at all costs.

«What we've seen in Toronto is the new measures have prompted people to avoid mortgage insurance at all costs,» says Porter at BMO.

If you're into outdoors activities, the Hydro Flask is well worth the investment; running out of cold water when you're stuck in the woods is a disaster that should be avoided at all costs.

In fact, most career coaches would probably tell you to avoid it at all costs at the office.

They decide it is one of those things to go in the column of things to be avoided at all costs, along with poisonous spiders, and zombies.

The bank sought to fill the gap with a $ 200,000 SBA loan, something Wald wanted to avoid at all costs, recalling the consequences of the $ 30,000 SBA loan he'd received in 1996 (and since paid off): NetForce had trouble securing the kind of financing it needed because the SBA had taken a blanket lien on all the company's assets.

In the end, she says, it still came at a cost to the organization, but frank discussion helped avoid what could have been a disastrous outcome.

Three years ago, she force fed herself and «avoided exercise at all costs» to make herself a size 16 and get more jobs in the plus size sector, which represents a $ 17 billion business.

The human tendency to hope for the best and try to avoid failure at all costs gets in the way, and organizational hierarchies exacerbate it.

thanks, and yes, a pittance of a pension and regular checkups keep us on budget and head off any problems — best decision i ever made (financial or otherwise) was serving our country doing search - and - rescue, oil and chemical spill remediation, etc. (you can guess the branch of service)-- along the way, frugal living, along with dollar - cost averaging, asset allocation, and diversification allowed us to retire early — Vanguard has been very good over the years, despite the Dot Bomb, 2002, and the recession (where we actually came out better with a modest but bargain retirement home purchase)... it's not easy building additional «legs» on a retirement platform, but now that we're here, cash, real estate, investments and insurance products, along with a small pension all help to avoid any real dependence on social security (we won't even need it at full retirement age)-- however, like nearly everybody, we're headed for Medicare in several years, albeit with a nice supplemental and pharmacy benefits — but our main concern is staying fit, active, and healthy!

One of the big upsides of a DRIP is that this regular investment in a particular stock assures you'll be benefiting from dollar cost averaging, meaning that because you're regularly investing — quarterly, in most cases — and because stocks rise and fall, you'll avoid buying a stock at its highest price.

In the future I will avoid all P2P lenders at all costs.

The right concern for the Fed now should be to signal its commitment to accelerating growth and avoiding a return to recession, even at some cost in terms of other risks.

However, the content of the resulting reports is still far from perfect, particularly from the investor's perspective, bearing in mind that an additional compliance exercise must be avoided at all costs.

While high - interest debt should be avoided at all costs, a 0 - percent - interest offer could be useful in a pinch, so long as you pay it off before the deal expires.

Others take pleasure in avoiding the crowds at all costs and shop exclusively online (hello, free shipping!).

This structural break coincides with the attainment of a voice in politics by ordinary people in developed economies: since voters rarely opt for economic pain, their elected representatives soon found they had to avoid it at all costs.

Still, the income - tax break on any earnings used to pay legitimate college expenses, coupled with the ability to avoid borrowing costs for tuition later, could make even lower returns in a 529 plan equivalent to higher returns outside of one — and better than not saving at all.

This was to avoid the temptation to seek a short - term stimulus to growth for political reasons, at the cost of a persistent rise in inflation.

My colleague Hailley has long admired the original framework for setting goals from Warren Buffett — a method where you write down 25 things you want to accomplish in your career, and from that, pick the top five as the focus and put the other 20 on an «avoid at all costs» list.

So avoid discussions about who's in and who's out at all costs.

But if I am going to go on in the direction of what Jesus meant by «life» and «more abundantly,» then I have to avoid that duality of matter and spirit at all costs.

This stands in direct contrast to the Scriptures, the Fathers, and the saints, whose premise is that suffering is not something to be avoided at all costs — one can learn to live through it.

It had nothing to do with Christianity because I was not raised in a family of faith; rather, in a home with an alcoholic, there was an underground but extremely strong message that negative emotions should be avoided at all costs.

The conflict and relational stress that we've been avoiding at all costs seems to loom bigger when we're in close proximity with others.

Rather, the default position among local churches should not be to spare no expense in their construction, but to avoid church buildings at all costs.

Moreover it needs to be carefully explained that the promotion and use of artificial contraceptives encourages an exploitative attitude to sexual intimacy in which the generation of new life is seen as a «failure», a «disaster», something to be avoided at all costs.

In this scheme, the Church is said to have a necessary «masculine feel,» and church leaders are warned to avoid the «effeminizing of the church» at all costs.

What has to be avoided at all costs, in other words, is a blueprint for social reform which in the end favors only one group in society in its quest for greater economic and political self - determination.

Current efforts at energy conservation are inadequate; while the need for more appropriate patterns of individual and corporate energy consumption is clear, the statement also recognizes the necessity of avoiding unnecessary economic and social dislocations in the transition to energy efficiency (e.g., unemployment or increased costs due to lowered volume).

And yet the opposite fault glares at us from across American Christianity: the idea that suffering is not at all our lot, should be shunned and avoided at all costs, and is a valid reason to hoard what we have, defend ourselves at any cost and as proactively as we think we need to against others, and rely on opiates as a matter of course, without viewing suffering at all as anything that might in any way or to any extent be worth enduring.

Another problem in consultation is that of syncretism, that is, conducting consultation in such a way that disagreement is avoided at all costs and the parties must stick together regardless of the means used or the goals set.

And I view them with pity, I have stopped trying to hold coherent philosophical conversations with them (in person) for a long time, and avoid them at all costs, because what disease they have is surely contagious, especially at a young age.

Like in a crudités or veggie platter situation, I avoid them at all cost.

If you know me in real life, you know what a foul mood driving around will make me since I tend to avoid it at all costs (I bike to work everyday, rain or shine).

Also we took a punt on Chambers - to get in there early & hopefully avoid the sort of fee Stones would cost someone now he is a semi-established young England international CB - but Chambers is clearly not viewed as ready for regular action at CB with us.

It's suggested that the pair could initially leave on loan before being sold next summer, as that strategy could avoid seeing them lose value if they were to stay at Milan for the remainder of the campaign having cost the club $ 65m in total.

I see a lot of people saying «it's either Chriss or Bender» — while I would take Bender over Chriss in a heartbeat (Chriss has anger problems, and after the Morri debacle, I want to avoid duplicating that culture at all costs), I don't see why we should get rid of either of them just yet.

With Philippe Coutinho still out injured and having lost Sadio Mane to international duty at the Africa Cup of Nations, Liverpool need back - up in the wide attacking areas and need to move quickly to avoid it costing them in the title race.

Although San Diego was still able to cover the spread in that matchup, public bettors are avoiding the Chargers at all costs on Sunday.

A player who has ambition will avoid Arsenal at all cost, and those half decent players we have move in time as well

Lets avoid stating slow at all cost, when Lpool are threatened from the onset they can really be poor but once they have there noses in front as seen in the City game then you are in trouble.