Three celestial guides, Mrs. Which (two - time Academy
Award ® nominee Oprah Winfrey), Mrs. Whatsit (Oscar ®, Golden Globe ® and Emmy ® winner Reese Witherspoon) and Mrs.. Who (Emmy nominee Mindy Kaling), come to Earth to share their wisdom and love with
struggling eighth - grader Meg Murry (Storm Reid) as she journeys across dimensions with classmate Calvin (Levi Miller) and younger brother Charles Wallace (Deric McCabe) in
search of her father (Chris Pine), a world - renowned physicist who mysteriously disappeared four years ago.