Sentences with phrase «axon degeneration»

Individuals with CMT1 usually show signs of axon degeneration.

For his research project to explore a novel idea in the field of neurodegeneration, defining the molecular cascade that controls axon degeneration, which is a key early event in glaucoma, Dr. Richard Libby was awarded the 2017 Shaffer Prize from Glaucoma Research Foundation.

This means Ind - Cl not only inhibits inflammation but is capable of reducing axon degeneration and restoring neuronal function.»

However, the researchers also found that the death spiral can be slowed when this communication is blocked using a laboratory method that could inspire pharmacological therapies to treat pathological axon degeneration.

Not exact matches

«This is not the first gene identified whose loss protects mammalian axons from degeneration,» DiAntonio says.

Three days after injury, these axons are protected from degeneration because they are missing Phr1, a gene involved in removing damaged axons from the body.

«Treating axonal degeneration could potentially help a lot of patients because there are so many diseases and conditions where axons are inappropriately lost,» says Aaron DiAntonio, MD, PhD, professor of developmental biology.

Experiments conducted in mice and in human ALS cells reveal that when RIPK1 is out of control, it can spark axonal damage by setting off a chemical chain reaction that culminates in stripping the protective myelin off of axons and triggering axonal degeneration — the hallmark of ALS.

But a new study by University of Virginia researchers challenges this idea and suggests that axons coordinate each other's destruction, thereby contributing to the degeneration that makes neurological diseases so devastating and permanent.

The new study by researchers at The Neuro shifts the focus to the loss or degeneration of axons, the nerve - cell «branches» that receive and distribute neurochemical signals among neurons.

Severing axons, or axotomy, is a simple way to study the molecular basis of neurodegeneration as it leads to the activation of explosive axonal degeneration.

What would be immensely helpful is a drug that could minimize the degeneration of axons, thus reducing the rate and degree of MS progression.

«This is not the first gene identified whose loss protects mammalian axons from degeneration,» DiAntonio said.

Many scientists have examined axon development and degeneration in two - dimensional (2D) systems.

«Treating axonal degeneration could potentially help a lot of patients because there are so many diseases and conditions where axons are inappropriately lost,» said Aaron DiAntonio, MD, PhD, professor of developmental biology.

Therefore understanding the dysfunctional molecular pathways that cause mDA axonal degeneration, and targeting these to protect or re-grow mDA axons, may be a promising therapeutic approach for PD.

Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration Baltan, S., Inman DM., Danilov, CA., Morrison, RS., Horner, PJ.

In patients, the peripheral neuropathy is characterized by degeneration of sensory axons and is clinically manifested as numbness, pain, and thermohyperesthesia in hands and feet.