Sentences with phrase «axon development»

Figure summarizing the three major steps of axon development in the CNS: axon specification during neuronal polarization, axon growth and guidance, axon branching and presynaptic development (Modified from Lewis, Courchet and Polleux, The Journal of Cell Biology, 2013).

Click to see how TSC proteins control axon development.

Many scientists have examined axon development and degeneration in two - dimensional (2D) systems.

Not exact matches

In a specific example of this scenario, co-occurrence of two alternative variants of the cell polarity factor Cdc42 in the same neuron was essential for proper development of a single axon and several functional dendrites.

The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.

«This technique measures the diffusion of water in the brain tissues, which can tell you a lot about the development of neurons and axons,» Monson said.

During brain development, neurons have to connect to each other, which they do by extending their long axons to touch one another.

In a disorder called agenesis of the corpus callosum (agenesis meaning «lack of development»), many axons can not find their way out of their own hemisphere.

Several neurological disorders, including autism and schizophrenia, are thought to be driven in part by the failure of myelin to properly surround axons during development.

«When an embryo is building its nervous system, there can be inappropriate or excessive axonal sprouts, or axons that are only needed at one time in development and not later,» DiAntonio says.

Specifically, the research sheds light on the role of RPM - 1 in the development of axons or nerve fibers — the elongated projections of nerve cells that transmit electrical impulses away from the neuron via synapses.

A paper in the journal Neural Development shows that RPM - 1 is localized at both the synapse and the mature axon tip, evidence that RPM - 1 is positioned to potentially coordinate the construction of synapses with regulation of axon extension and termination.

The study describes how RPM - 1 regulates the activity of a single protein known as DLK - 1, a protein that regulates neuron development and plays an essential role in axon regeneration.

During development, axons must follow specific paths in the nervous system in order to properly form neural circuits and allow neurons to communicate with one another.

«To reach their target, growing axons rely on molecules known as guidance cues, which instruct them on which direction to take by repelling or attracting them to their destination,» explains Dr. Charron, Director of the Molecular Biology of Neural Development research unit at the IRCM.

During early development, axons are pruned to ensure normal growth of the nervous system.

«When an embryo is building its nervous system, there can be inappropriate or excessive axonal sprouts, or axons that are only needed at one time in development and not later,» DiAntonio said.

During development, these cells migrate with the axons that they will myelinate, and depend on those same axons for appropriate signals to survive and differentiate.

She disproved the theory that neurons are assigned a certain identity in the embryo, discovered that neurons don't all myelinate their axons in the same way, and is now a pioneer in creating brain organoids to study basic aspects of development.

Yi J.J., Barnes A.P., Hand R., Polleux F. and Ehlers M.D. (2010) TGFβ signaling specifies axons during brain development.

Using viral transfection methods, Dr Banker has identified some of the signals that target integral membrane proteins to axons and dendrites and are using this approach to study targeting at early stages in the development of polarity.

We will leverage state - of - the - art bioinformatic and biological approaches for investigating how these factors interact in combination to regulate axon growth during RGC development and test the potential of such factors for regenerating RGC axons in a rodent model of optic nerve injury.

In neural development, Semaphorin 3B (SEMA3B) is thought to play a role in guiding axons by repulsion.

Shimojo M, Courchet J, Pieraut S, Torabi - Rander N, Sando R 3rd, Polleux F, Maximov A. (2015) SNAREs Controlling Vesicular Release of BDNF and Development of Callosal Axons.

Finally, a large subset of genes is linked to brain development, including neural growth (NINJ1, NTM), axon and glial guidance (MATN2, DCC, ASTN1), synapse plasticity (DLGAP1), neurogenesis (ALK, NUMB) and a variety of neurological disorders.

Furthermore, the success of this project can lead to the development of novel axon - regenerating therapeutics that could transform the clinical treatment of angle - closure glaucoma and other types of optic neuropathies, as well as have the potential to be adapted to regenerating the long - distance axonal projections damaged by spinal cord injury, brain trauma, and white matter stroke.

Several of these are known to be important for neural development in worms — for example, the gene cle - 1 is needed for axon guidance.

His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.

Freelance Draftsperson, ASSA Properties 11.09 - 02.10 — Worked with industrial furniture designer to draft and finalize furniture layout within hotel spaces of condominium development project (Cassa NY by Ten Architectos)-- Finalize furniture schedule — Furniture shop drawings (axon)

ASSA Properties 2009 — 2010 Freelance Draft - person / Freelance Model - Maker • Collaborated with industrial furniture designers to draft, review and finalize furniture layouts within the hotel portion of a mixed - use development (Cassa NY b y Ten Architectos) • Created shop drawings of furniture (axon) • Finalized furniture schedules and logistics • Constructed 1/4» scale detail bass wood model of condominium unit for use in property sales, including bath and kitchen fixtures as well as furniture

EXPERIENCE: Intern Architect, Garrison McNeil and Associates, Architects and Planners 04.08 - present — Office Managerial Duties: office support duties, purchasing manager — Marketing: Letters of Interest; RFQ's; RFP's — Zoning / Building Code Analysis — Site Survey — Development of schematic and design development phase plans, elevations, sections, and rendered axonometrics — Construction Documents: Fluent in construction document standards and construction details (section and axon)-- In - house Specification and Project Manual Compilation: proof - reading and writing architectural specifications — Presentation Prep: materials boards, presentaDevelopment of schematic and design development phase plans, elevations, sections, and rendered axonometrics — Construction Documents: Fluent in construction document standards and construction details (section and axon)-- In - house Specification and Project Manual Compilation: proof - reading and writing architectural specifications — Presentation Prep: materials boards, presentadevelopment phase plans, elevations, sections, and rendered axonometrics — Construction Documents: Fluent in construction document standards and construction details (section and axon)-- In - house Specification and Project Manual Compilation: proof - reading and writing architectural specifications — Presentation Prep: materials boards, presentation boards