Sentences with phrase «axon guidance of»
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The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.
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His laboratory implicated endocannabinoids in axon guidance and identified the molecular substrates of Δ9 - tetrahydrocannabinol action in developing neurons.
«A better understanding of the mechanisms involved in axon guidance will offer new possibilities for developing techniques to treat lesions resulting from spinal cord injuries, and possibly even neurodegenerative diseases.»
In collaboration with the Program in Neuroengineering at McGill University, Dr. Charron's team developed an innovative technique to recreate the concentration gradients of guidance cues in vitro, that is to say they can study the developing axons outside their biological context.
In those instances, we revealed that a combination of guidance cues can behave in synergy with one another to help the axon interpret the gradient's direction.»
«We found that the steepness of the gradient is a critical factor for axon guidance; the steeper the gradient, the better the axons respond to guidance cues,» says Tyler F.W. Sloan, PhD student in Dr. Charron's laboratory and first author of the study.
«To reach their target, growing axons rely on molecules known as guidance cues, which instruct them on which direction to take by repelling or attracting them to their destination,» explains Dr. Charron, Director of the Molecular Biology of Neural Development research unit at the IRCM.
«In addition, we showed that the gradient of one guidance cue may not be steep enough to orient axons.
My lab is investigating the normal cellular functions of signaling pathways implicated in neurological disease, with an emphasis on axon growth and guidance.
Misrouting has been attributed to the absence of the directional cues required for normal RGC axon guidance.
To investigate this, we are characterizing the role of the SMN protein in axon growth and guidance in vivo, as well as identifying proteins and mRNA targets that interact with SMN in neurons.
In the 1990s, scientists found the first of those signaling systems, a family of ephrin proteins that are present in graded fashion in the brain and are involved in axon guidance.
PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C - terminal fragments.
Our studies reveal previously - unknown roles for glia in pioneer - axon guidance, and suggest conserved principles of brain formation.
Figure summarizing the three major steps of axon development in the CNS: axon specification during neuronal polarization, axon growth and guidance, axon branching and presynaptic development (Modified from Lewis, Courchet and Polleux, The Journal of Cell Biology, 2013).
Finally, a large subset of genes is linked to brain development, including neural growth (NINJ1, NTM), axon and glial guidance (MATN2, DCC, ASTN1), synapse plasticity (DLGAP1), neurogenesis (ALK, NUMB) and a variety of neurological disorders.
The axon guidance pathway associated with promoter mutations is implicated in the involvement of nerve cells in pancreatic cancer.
In Aim 1, we generate cell specific - knockout mice and characterize deletion of expression of distinct genes relevant to axon guidance.
Several of these are known to be important for neural development in worms — for example, the gene cle - 1 is needed for axon guidance.