Sentences with phrase «axon loss»

Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.

We're focused on glaucoma and it has to do with a set of very surprising findings in a region that we know is critical for axon loss in glaucoma, which is the optic nerve head.

At the same time, Freeman and others have shown that SARM - dependent signaling pathways also drive axon loss in neurodegenerative conditions including glaucoma, traumatic brain injury and peripheral neuropathy.

Not exact matches

«If we can find ways to block or inhibit CD11b early on, we should be able reduce or limit the amount of abnormal leukocyte trafficking, inflammation, and the resulting demyelination and loss of axons in AIDP,» he said.

«This is not the first gene identified whose loss protects mammalian axons from degeneration,» DiAntonio says.

There are two categories of CMT: those caused by the loss of axons in the peripheral nerves (CMT2) and those characterized by a malfunction in the Schwann cells that make up the myelin sheath, the protective coating that surrounds the nerve fibers and allows them to conduct nerve signals at high speeds (CMT1).

The new study by researchers at The Neuro shifts the focus to the loss or degeneration of axons, the nerve - cell «branches» that receive and distribute neurochemical signals among neurons.

«This is not the first gene identified whose loss protects mammalian axons from degeneration,» DiAntonio said.

«In this case, the loss of axons is not caused by disease,» DiAntonio said.

Loss of lower motor neurons (LMNs) and large - caliber axons was conspicuous in Scyl1 -LRB-- / --RRB- animals.

We will use a glaucoma model to study whether the gene Sarm1 plays a role in glaucoma - induced axon death and synapse loss in the retina and brain.

This is supported by post-mortem studies showing a modest loss of mDA axons in the striatum 1 year after PD diagnosis, with a complete loss of mDA striatal innervation in patients 4 years after diagnosis, while some mDA neuronal soma remained [6].

Vision loss from glaucoma occurs when axons in the optic nerve become damaged and can no longer carry visual information to the brain.

(2007) Shrinkage and Loss of RGC Axons in a New Latex Bead Rat Model of High - Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 2878).

His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.

10:06 - Gerardo Morfini: HD patients have loss of «white matter» in the brain, which is made of axons, suggesting it's important to understand.

Myelin twists around the axon like a jelly - roll cake and prevents the loss of electrical signals.

Oxidative stress can also lead to loss of neurons or neuronal axons from the colon and consequently a loss of motility.