Sentences with phrase «axonal cytoskeletal»

Specifically, the aims of recent projects were to determine whether axonal cytoskeletal disruption, transport abnormalities, and electrophysiological dysfunction occur prior to RGC death in experimental glaucoma (rodent and non-human primate models) and whether some of these phenomena are detectable by clinically - applicable means.

We aim to close this gap by implementing a novel assay to simultaneously assess the integrity of the axonal cytoskeletal structure (using electron microscopy) and a functional (physiological) correlate of healthy cytoskeletal structure, namely active axon transport, within individual RGC axons at an early stage of experimental glaucoma.