Sentences with phrase «axonal damage»

Under the microscope the axonal damage is called Diffuse Axonal Injury (DAI).

Experiments conducted in mice and in human ALS cells reveal that when RIPK1 is out of control, it can spark axonal damage by setting off a chemical chain reaction that culminates in stripping the protective myelin off of axons and triggering axonal degeneration — the hallmark of ALS.

In a final set of experiments, the researchers used necrostatin - 1 to treat mice with axonal damage and hind leg weakness, a telltale sign of axonal demise similar to the muscle weakness that occurs in the early stages of ALS in humans.

Necrostatin - 1 not only restored the myelin sheath and stopped axonal damage but also prevented limb weakness in animals treated with it.

The findings suggest that RIPK1 may be involved in a range of other neurodegenerative diseases marked by axonal damage, including multiple sclerosis, certain forms of spinal muscular atrophy and even Alzheimer's disease.

Instead, RIPK1 appears to fuel axonal damage across various forms of inherited and acquired forms of ALS.

Tau helps provide structure to brain cells, is a marker for axonal damage — and is also what McKee finds spotted throughout the brains she examines in her Boston U. lab.

Not exact matches

Instead, the researchers found that dendritic, but not axonal, varicosities could be induced by prolonged treatment with glutamate, an excitatory neurotransmitter that is released from damaged axons.

Chronic autoimmune inflammatory damage to the brain produces waves of demyelination (blue line in the graph) and cumulative axonal loss (green line in the graph) in different intensities along time leading to all MS phenotypes.

Furthermore, the success of this project can lead to the development of novel axon - regenerating therapeutics that could transform the clinical treatment of angle - closure glaucoma and other types of optic neuropathies, as well as have the potential to be adapted to regenerating the long - distance axonal projections damaged by spinal cord injury, brain trauma, and white matter stroke.

If your loved one has suffered diffuse axonal injury (DAI), several areas of the brain have been affected by lesions, resulting in widespread damage.

Diffuse axonal injury — damage to the brain cells that isn't always as outwardly visible as other types of brain injury but can lead to permanent brain damage and death.