In a final set of experiments, the researchers used necrostatin - 1 to treat mice with axonal damage and hind leg weakness, a telltale sign of
axonal demise similar to the muscle weakness that occurs in the early stages of ALS in humans.
Strikingly, the researchers noticed the same signs of
axonal demise in spinal cord cells obtained from human patients with ALS.
But up until now, scientists were unaware of its role in
axonal demise and ALS.