Sentences with phrase «axonal outgrowth»

Here we identify protein kinase N1 (PKN1) as a novel key player in fine - tuning the balance between axonal outgrowth and presynaptic differentiation in the parallel fiber — forming (PF - forming) cerebellar granule cells (Cgcs).

In summary, our results demonstrate that PKN1 functions as a developmentally active gatekeeper of AKT activity, thereby fine - tuning axonal outgrowth and presynaptic differentiation of Cgcs and subsequently the correct PF - PC synapse formation.

In vitro, Pkn1 — / — Cgcs exhibited deregulated axonal outgrowth, elevated AKT phosphorylation, and higher levels of neuronal differentiation - 2 (NeuroD2), a transcription factor preventing presynaptic maturation.