Sitting at the top of this genetic cascade is the Sim1 gene, which also controls both the segregation and
axonal projections of the PVN and SON.
An intriguing clue to this selectivity is provided by Setola et al., who identify a truncated form of SMN1 that arises from an alternative spliced SMN1 transcript that is preferentially expressed in
the axonal projections of developing motor neurons.
Not exact matches
Although both types
of memory were laid down in the medial prefrontal cortex, they were stored along separate paths or
axonal projections, which in turn linked to different brain regions (Cell, DOI: 10.1016 / j.cell.2016.05.010).
In conclusion, our findings suggest that microstimulation, with its anatomical precision, physiologic - level currents, and action via
axonal projections, holds promise for modification
of memory circuits and thus for the treatment
of memory impairments in people suffering from neurological disorders.
The latter is particularly important for the establishment
of long
axonal projections, which requires coordinated long - range organelle transport.
Furthermore, the success
of this project can lead to the development
of novel axon - regenerating therapeutics that could transform the clinical treatment
of angle - closure glaucoma and other types
of optic neuropathies, as well as have the potential to be adapted to regenerating the long - distance
axonal projections damaged by spinal cord injury, brain trauma, and white matter stroke.
(In contrast to these functions, processing speed has no direct anatomic counterpart, but rather is a function
of axonal projections that connect brain regions.