Sentences with phrase «axonal proteins»
We hypothesize that these aggregating proteins also block the transport of normally transported axonal proteins, and thus cause neurodegeneration and neuronal death by impairing axonal transport.
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Ice hockey players with sports - related concussion have elevations in the axonal injury biomarker total tau and the astroglial injury biomarker S - 100 calcium - binding protein B, according to a study published online March 13 in JAMA Neurology.
Dr. Barker and his colleagues show that the activity of certain «executioner» caspases (caspase - 3 and caspase - 9) induce axonal degeneration and that their action is suppressed by a protein termed XIAP (X-linked inhibitor of apoptosis).
Here we identify protein kinase N1 (PKN1) as a novel key player in fine - tuning the balance between axonal outgrowth and presynaptic differentiation in the parallel fiber — forming (PF - forming) cerebellar granule cells (Cgcs).
We study the influence of the Maillard reaction (leading to advanced glycation endproducts, AGEs) on the function of specific proteins which are involved in the axonal transport.
In my laboratory, we hypothesize that age - dependent neuronal death occurs partly in response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survival.
AGEs impair this axonal transport and alpha adrenergic blockers (acting on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look on the molecular mechanisms of this process (crosslinking of motor proteins in axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.
Aβ proteins, which build up to toxic levels in the brains of people with Alzheimer's disease, impair the axonal transport of these cargoes.
Aim 3: We are specifically interested how defects of nuclear proteins cause axonal phenotypes using live cell imaging techniques, inhibitor studies, laser irradiation, - omics approaches.
A) Proteins that associated with axonal guidance and signaling were significantly enriched (p = 6 × 10 − 20) in the CSF proteomes for all pooled samples.
A specific example relates to networks relevant to neurological function such as axonal guidance (Figures S2A and B), where the proteins in CFS were further decreased relative to nPTLS.
Furthermore, CRF - induced phosphorylation of tau protein interferes with neuronal energetics as it impairs axonal transport of mitochondria.»