Sentences with phrase «axonal signals»

Dr. Ding will soon begin to use regenerative medicine to transform these inhibitory glial cells into a non-inhibitory CNS cell type, eliminating the field of scar tissue and permitting the transmission of axonal signals.

Not exact matches

First, looking at a study of 185 cases of childhood epilepsy, Wittkowski's team found that mutations in genes that control axonal guidance and calcium signaling — both of which are important early in the developing brain when neurons are forming the appropriate connections — led to increased chances of having the disorder.

«Now we know the signals for fear and pleasure can be transmitted by different axonal projections, new targeted treatments might be envisioned,» he says.

GS showed genome - wide significant slope decrease by — 3.86 (95 % CI: — 4.64 to — 3.07, p < 2 × 10 — 16) per standard deviation of the GS for 6 SNPs mapping to genes involved in neuronal development and signaling, axonal myelinization, and glutamatergic / GABA neurotransmission.

In terms of pathogenic mechanisms of PD, given that miR - 181a is selectively up - regulated in nigrostriatal DA neurons of the PD brain [13], our current findings suggest that this up - regulation in miR - 181a may contribute to the ongoing mDA axonal degeneration by inhibiting BMP - Smad signalling in vivo.

A) Proteins that associated with axonal guidance and signaling were significantly enriched (p = 6 × 10 − 20) in the CSF proteomes for all pooled samples.

One of Dr. Charron's objectives is to identify and characterize the components of the Shh signalling pathway in axonal guidance.

There is also more diffuse abnormal signal noted in the corpus callosum and periventricular brain indicating diffuse axonal shear injury.