Sentences with phrase «axonal transport»
Axonal transport refers to the process through which cells in our body, particularly nerves, transport essential materials up and down their long, thin extensions called axons. Think of it like a highway system where different components like proteins, molecules, and organelles travel to maintain and repair the nerve cells. This transport system helps nerves function properly and communicate effectively within our body. Full definition
In my laboratory, we hypothesize that age - dependent neuronal death occurs partly in response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survival.
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Neurotrophic factors are perturbed in AD and unevenly distributed due to impairment in axonal transport [105].
When it is experimentally prevented (either by severing the projecting axons, by treating them with the drug vinblastine, which blocks axonal transport, or by administering 6 - hydroxydopamine, which destroys the nerve endings), the innervating sympathetic neurons in the ganglion die off.
We hope that deciphering the mechanisms by which axonal transport contributes to neurodegeneration, either in normal aging or in disease conditions, will allow us to design new therapeutic strategies to treat these maladies.
FHV - 1 establishes latency in the trigeminal ganglia and can travel back to the eye via anterograde axonal transport.
The membrane associated adaptor ankyrin - B (AnkB) promotes fast axonal transport and elongation by coupling dynactin to multiple organelles through binding to phosphatidylinositol 3 - phosphate lipids in these cargos.
In the absence of the Aβ challenge, tau reduction had no effect on axonal transport.
«Whether tau affects axonal transport or not has been a controversial issue, and nobody knew how to prevent Aβ from impairing this important function of neurons.
Scaling great walls When they both started at Penn, Lee had a project on the effects of nerve growth factor on PC12 cells, and Trojanowski was studying axonal transport and endocytosis.
(2007) Chronic Minocycline Treatment Decreases Microglial Activation and Improves Retrograde Axonal Transport in Retinal Ganglion Cells in DBA / 2J Retina (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3291).
Calkins DJ., Inman, P., Horner PJ., Crish, S. (2009) Progression of Deficits in Anterograde Active Axonal Transport in the Retina of the DBA / 2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 4317).
Marsh - Armstrong, N., Oglesby, E., Buckingham, B., Horner, PJ., Soto, I. (2007) Molecular Changes in DBA / 2J Retinal Ganglion Cells Coinciding With Axonal Transport Dysfunction (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 5553).
(2010) Target Response to Axonal Transport Loss in Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2142).
We hypothesize that these aggregating proteins also block the transport of normally transported axonal proteins, and thus cause neurodegeneration and neuronal death by impairing axonal transport.
Hayashi and Niwa expect the non-invasive force measurement method to be a strong, new tool in understanding the physical mechanism of neuronal diseases caused by deficits in axonal transport.
The authors summarize: «Our study shows that rabies virus can not only hijack the transport systems of the neuron, but might also manipulate the axonal transport machinery to facilitate its own arrival at the cell body, and from there to the central nervous system at maximum speed.»
We study the influence of the Maillard reaction (leading to advanced glycation endproducts, AGEs) on the function of specific proteins which are involved in the axonal transport.
AGEs impair this axonal transport and alpha adrenergic blockers (acting on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look on the molecular mechanisms of this process (crosslinking of motor proteins in axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.
«We wondered whether this striking rescue might be caused, at least in part, by improvements in axonal transport.»
Aβ proteins, which build up to toxic levels in the brains of people with Alzheimer's disease, impair the axonal transport of these cargoes.
Southern California and joined the Polleux lab in 2011 where he studies the function of LKB1 in axonal transport.
Storm - Mathisen J, Wold JE (1981) In vivo high - affinity uptake and axonal transport of D -[2,3 - 3H] aspartate in excitatory neurons Brain Res, 230 (1 - 2), 427 - 33 PubMed 6172187
The Aβ slowed down axonal transport of mitochondria and growth factor receptors, but only in neurons that produced tau and not in neurons that lacked tau.
Brad Fortune, OD, PhD Devers Eye Institute, Portland, OR The Dr. Miriam Yelsky Memorial Research Grant Project: Axonal Transport of Mitochondria: Developing an In Vivo Imaging Assay for Glaucoma Research
The UNM art will include a video of axonal transport by UNM neuroscientist and composer, Dr. Elaine Bearer, set to her own music.
(2008) Trpv1 contributes to pressure - induced death and disruption of axonal transport in RGCs (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5481).