Sentences with phrase «axonal transport of»

Furthermore, CRF - induced phosphorylation of tau protein interferes with neuronal energetics as it impairs axonal transport of mitochondria.»

Brad Fortune, OD, PhD Devers Eye Institute, Portland, OR The Dr. Miriam Yelsky Memorial Research Grant Project: Axonal Transport of Mitochondria: Developing an In Vivo Imaging Assay for Glaucoma Research

Aβ proteins, which build up to toxic levels in the brains of people with Alzheimer's disease, impair the axonal transport of these cargoes.

Axonal Transport of TDP - 43 mRNA Granules Is Impaired by ALS - Causing Mutations.

In my laboratory, we hypothesize that age - dependent neuronal death occurs partly in response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survival.

The lethal effects of blocking the axonal transport of NGF can be completely overcome, however, by supplying the cell bodies with externally administered NGF.

This retrograde axonal transport of NGF is absolutely essential for the survival of the innervating neurons.

Work in several laboratories has shown that the retrograde axonal transport of NGF follows its interaction with specific receptor sites on the nerve terminals of the newly established fibers.

Not exact matches

This interrupts the transport of cellular materials along axonal microtubules, causing these materials to accumulate at several points along the axon where they may give rise to varicosities.

Hayashi and Niwa expect the non-invasive force measurement method to be a strong, new tool in understanding the physical mechanism of neuronal diseases caused by deficits in axonal transport.

We study the influence of the Maillard reaction (leading to advanced glycation endproducts, AGEs) on the function of specific proteins which are involved in the axonal transport.

We hypothesize that these aggregating proteins also block the transport of normally transported axonal proteins, and thus cause neurodegeneration and neuronal death by impairing axonal transport.

The latter is particularly important for the establishment of long axonal projections, which requires coordinated long - range organelle transport.

AGEs impair this axonal transport and alpha adrenergic blockers (acting on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look on the molecular mechanisms of this process (crosslinking of motor proteins in axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.

In the absence of the Aβ challenge, tau reduction had no effect on axonal transport.

«Whether tau affects axonal transport or not has been a controversial issue, and nobody knew how to prevent Aβ from impairing this important function of neurons.

Southern California and joined the Polleux lab in 2011 where he studies the function of LKB1 in axonal transport.

Scaling great walls When they both started at Penn, Lee had a project on the effects of nerve growth factor on PC12 cells, and Trojanowski was studying axonal transport and endocytosis.

We aim to close this gap by implementing a novel assay to simultaneously assess the integrity of the axonal cytoskeletal structure (using electron microscopy) and a functional (physiological) correlate of healthy cytoskeletal structure, namely active axon transport, within individual RGC axons at an early stage of experimental glaucoma.

Specifically, the aims of recent projects were to determine whether axonal cytoskeletal disruption, transport abnormalities, and electrophysiological dysfunction occur prior to RGC death in experimental glaucoma (rodent and non-human primate models) and whether some of these phenomena are detectable by clinically - applicable means.

The UNM art will include a video of axonal transport by UNM neuroscientist and composer, Dr. Elaine Bearer, set to her own music.

(2008) Trpv1 contributes to pressure - induced death and disruption of axonal transport in RGCs (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5481).