When
the axons reaching across the divide were cut with a knife, the interconnectivity between the cortical neurons inside their own compartment was relatively unaffected, whereas the striatal neurons showed no electrophysiological activity.
The new study by the Inagaki lab showed that neurons will produce four times more traction force when placed on adhesive substrates coated with laminin than those without laminin, assuring
the axons reach their final destination.
When
an axon reaches the correct part of the brain, it needs to choose among the many neurons there.
Not exact matches
Moreover, both the diameter of the
axons and the thickness of their myelin sheaths progressively increased until they
reached the values observed in the auditory system of the adult animal.
To do this, these nerve cells send out
axons, long, incredibly thin projections that
reach out to other regions.
Axons in particular can travel spectacular distances to
reach astonishingly precise targets.
Once a specific threshold is
reached, an electrical signal travels down the
axon — the nerve fibers within the neuron — and the neuron fires.
The third, a powerful growth factor called GDNF, was later injected into sciatic nerves to lure the
axons to
reach out to peripheral muscles.
In the final experiment, the researchers followed the PBelCGRP neurons» long -
reaching branches (called
axons) to the cells they connect with in other regions of the brain.
MouseLight has already revealed new information, including the surprisingly extensive number of brain regions that a single
axon can
reach.
Contrary to their name, SA cells actually have very long
axons, and they
reach from the neighborhood of one glomerulus to others, relatively far off in the bulb.
Over the past few decades, the scientific community has struggled to understand why more than one guidance cue would be necessary for
axons to
reach the proper target.
«To
reach their target, growing
axons rely on molecules known as guidance cues, which instruct them on which direction to take by repelling or attracting them to their destination,» explains Dr. Charron, Director of the Molecular Biology of Neural Development research unit at the IRCM.
The researchers found that new neurons arose in the higher vocal centre (HVC) and grew extensions (
axons) 3 millimetres long — long enough to
reach another brain region, the nucleus robustus archistriatalis (RA).
Injected botulinum toxin is taken up in
axons and
reaches the cell body, shown in green, before being transported into different neurons, shown in red.
This extreme morphology raises many cellular challenges: in particular, the delay required to transport organelles and cargo from the soma to distant parts of the
axon can
reach several hours and is incompatible with the rapid adaptation of subcellular homeostasis.
If the dendrites shrink, they can't
reach the
axons of neighboring cells or receive signals.