Sentences with word «azacitidine»

Azacitidine is a medication used to treat certain types of blood cancers, including leukemia. It works by helping the body's bone marrow produce normal blood cells. Full definition
A Phase 1b Dose Escalation Study Evaluating the Safety and Pharmacokinetics and Efficacy of Venetoclax in Combination with Azacitidine in Subjects with Treatment - Naive Higher - Risk Myelodysplastic Syndromes (MDS)
A Phase II Trial of Pevonedistat and Azacitidine in MDS or MDS / MPN Patients Who Fail Primary Therapy with DNA Methyl Transferase Inhibitors
It combines a similar drug called azacitidine — the standard of care therapy — with vitamin C.
In 2011, Baylin and colleagues published a study showing that some lung cancer patients who haven't responded to other therapies go into long - term remission when treated with a combination of azacitidine and an experimental HDAC inhibitor called entinostat.
The drug azacitidine, for instance, treats leukemia in this manner.
Even azacitidine, the first FDA - approved epigenomic drug, was used previously to treat bone - marrow stem cell disorders.
A phase I study showed that azacitidine priming followed by standard chemotherapy could be an effective approach to resistance in patients with newly diagnosed diffuse large B - cell lymphoma (DLBCL).
A Phase 1/2, Multicenter, Open - label Study of FT - 2102 as a Single Agent and in Combination with Azacitidine or Cytarabine in Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome with an IDH1 Mutation
A major milestone in epigenetic research occurred in 1980 when University of Southern California molecular biologist Peter Jones discovered that a compound called azacitidine — already known to stop leukemia cells from dividing — also blocks DNA methylation.
Several drugs that take advantage of this fact are currently in clinical trials, and one, azacitidine, is already FDA - approved for treating myelodysplastic syndrome, a condition in which the body manufactures too few blood cells.
Only a clinical trial that combines azacitidine with the blinded addition of either vitamin C or a placebo will give the true answer as to whether or not vitamin C increases the efficacy of azacitidine in patients.
The researchers treated 63 cancer cell lines (26 breast, 14 colorectal and 23 ovarian) with low - dose 5 - azacitidine (AZA), an FDA - approved drug for myelodysplastic syndrome, that reverses epigenetic changes by stripping off the methyl group that silences the gene.
Azacitidine is approved by the U.S. Food and Drug Administration (FDA) for treating all myelodysplastic syndromes (MDS) subtypes.
A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine or low - dose cytarabine is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.
A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine (AZA) or low - dose cytarabine (LDAC) is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.
One of those drugs, azacitidine, is already FDA - approved for the treatment of myelodysplastic syndrome.
The drugs, azacitidine (AZA) and decitabine (DAC), are epigenetic - targeted drugs and work to correct cancer - causing alterations that modify DNA.
Azad NS, El - Khoueiry A, Yin J, Oberg AL, Flynn P, Adkins D, Sharma A, Weisenberger DJ, Brown T, Medvari P, Jones PA, Easwaran H, Kamel I, Bahary N, Kim G, Picus J, Pitot HC, Erlichman C, Donehower R, Shen H, Laird PW, Piekarz R, Baylin S, Ahuja N. Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5 - azacitidine and entinostat: a phase 2 consortium / stand up 2 cancer study.
After decades of additional research, azacitidine (Vidaza) was approved by the Food and Drug Administration in 2004 for treating myelodysplastic syndrome (MDS), a cancer of the blood and bone marrow.
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