Sentences with phrase «azole drugs»

When they focused on genes involved in drug resistance, the group found that C. krusei differs from C. albicans; many of the sites that are often mutated in the target of azole drugs in resistant C. albicans are not mutated in C. krusei.

The azole drug family's biochemical target (the fungal enzyme lanosterol 14 α - demethylase) is well conserved.

Not exact matches

The three classes of antifungal drugs currently available — azoles, polyenes, and echinocandins — are far from optimal.

Doctors rely on three main drug classes — the azoles (e.g., fluconazole), the echinocandins, and amphotericin — to treat these severe infections, but often with limited success.

To do this, Cowen designed experiments in which fungal cells were exposed to two common classes of antifungal drugs: azoles and echinocandins.

Worryingly, C. auris is often highly resistant to major antifungal drugs (e.g., fluconazole and other azoles, amphotericin B, echinocandins), is difficult to identify with standard laboratory methods, and has caused outbreaks in healthcare settings.