These
antidepressants, which often have fewer side effects than others, prevent transmitting neurons from quickly soaking serotonin
back up that has not been absorbed by receptors
on other neurons, thus giving the neurotransmitter more time in the synapse to exert an effect.
I was afraid of drugs «Looking
back, I probably should have gone
on antidepressants the first time,» says Amy Sky, 47, of Toronto, who had severe postpartum depression after giving birth to each of her two children.
For example, cognitive behavioral therapy (CBT) had small positive effects
on disability and catastrophic thinking.66 Exercise therapy reduced pain and improved function in chronic low
back pain54; improved function and reduced pain in osteoarthritis of the knee51 and hip52; and improved well - being, fibromyalgia symptoms, and physical function in fibromyalgia.48 Multimodal and multidisciplinary therapies helped reduce pain and improve function more effectively than single modalities.55, 67 Multiple guidelines recommended acetaminophen as first - line pharmacotherapy for osteoarthritis68 - 73 or for low
back pain74 and nonsteroidal anti-inflammatory drugs (NSAIDs) as first - line treatment for osteoarthritis or low
back pain70, 74; first - and second - line drugs for neuropathic pain include anticonvulsants (gabapentin or pregabalin), tricyclic
antidepressants, and serotonin - norepinephrine reuptake inhibitors (SNRIs).75 - 78 Nonsteroidal anti-inflammatory drugs have been associated with hepatic, gastrointestinal, renal, and cardiovascular risks.63, 73,79