Over time,
bacteria in the lungs can become resistant to antibiotics making it increasingly difficult to treat lung infections and leading to irreversible damage to the lungs.
Lungs Newborns with certain types of
bacteria in their lungs are more likely to develop asthma.
Mice treated with the combination had almost 40,000 times fewer
bacteria in their lungs.
Substances produced by a harmful
bacterium in the lungs of cystic fibrosis patients may enhance the growth of other bacteria that, in turn, inhibit the harmful bacterium's biofilm, according to new research published in PLOS Pathogens.
Substances produced by a harmful
bacterium in the lungs of cystic fibrosis patients may enhance the growth of other bacteria that, in turn, inhibit the harmful bacterium's biofilm, according to new research.
«Infections with progressively resistant
bacteria in the lung shorten the lives of people with cystic fibrosis,» said Joseph M. Pilewski, M.D., co-director of the Adult Cystic Fibrosis Center at UPMC.
The researchers next showed that the Smurf1 gene controls M. tuberculosis growth in human macrophages and that the Smurf1 protein was found in association with
bacteria in the lungs of patients with tuberculosis infections.
In multiple trials of mice with both active and chronic TB infections, researchers report that one version of the new drug — an analog known as 1599 — was as good as or better than current TB drugs at reducing levels of
the bacteria in the lungs of mice.
To measure the differences in immune system function between the two groups of older mice, the researchers examined the lungs to assess damage, counted the number of
bacteria in the lungs, and calculated the number of the white blood cells (neutrophils).
In the past, researchers studied Pseudomonas in isolation despite the fact that it's rarely the lone
bacterium in the lungs of people with CF. Hoffman decided to study how Pseudomonas and Staphylococcus aureus — the other bacterium most commonly found in the lungs of cystic fibrosis patients — behave when the two are grown together.
***** Extra Vitamin E Protected Older Mice from Getting Common Type of Pneumonia http://now.tufts.edu/news-releases/extra-vitamin-e-protected-older-mice-getting-common-type-pneumonia «-- 1,000 times fewer
bacteria in their lungs» ****** These vitamins can work synergistically: Synergistic interactions between vitamin A and vitamin E against lipid peroxidation in phosphatidylcholine liposomes.
After a lengthy recovery after spinal surgery and fighting
bacteria in my lungs I discovered painting as a form of therapy!
Not exact matches
Mycoplasma pneumoniae is a
bacteria that can cause mild infections
in the
lung.
Examples I personally can document: a plague of deadly
bacteria in the newborn nursery killing 3 previously healthy newborns, exploding the fetal
lungs with too forceful dose of oxygen after birth by inexperienced doctor, crushing the skull during forceps extraction, overdose of adrenalin to newborn by a nurse, slow paging or slow response to call to resuscitate newborn, exploding the uterus (uterine rupture) and / or placental abruption as a result of high IV dose of oxytocin
in labor
in a low risk women.
Predatory
bacteria attenuate Klebsiella penumoniae burden
in rat
lungs.
Joint first author of the study, microbiologist Dr Jo Fothergill said: «We have discovered that the nasopharynx acts as a silent reservoir for
bacteria from which more serious infections
in the
lungs can develop.»
Despite the presumed virulence of the strain — experiments with mouse
lungs showed it produces 1000 times more
bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept
in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»
The scientists tested the new compound using a mouse model of TB and found that substituting R207910 for one of three antibiotics
in a treatment cocktail significantly reduced the time required to clear the animals»
lungs of
bacteria.
The
bacteria, Burkholderia cenocepacia, are highly antibiotic resistant and cause severe
lung infections
in people with cystic fibrosis.
After «inhaling» E. coli, for instance, the
lung attracted human white blood cells to attack and kill the
bacteria, a process scientists have long understood but never before witnessed
in vitro.
Immunotherapy with a live
bacterium combined with chemotherapy demonstrated more than 90 % disease control and 59 % response rate
in patients with malignant pleural mesothelioma (MPM), according to the results of a phase Ib trial presented today at the European
Lung Cancer Conference (ELCC) 2016
in Geneva, Switzerland.1
Image courtesy of iStockphoto / kajakiki
Bacteria hiding
in the
lungs might not be able to hide much longer.
«Because the
bacterium that causes TB can lie dormant
in someone's
lung for months or even years before it causes disease, we had no way of knowing whether a TB case we have just diagnosed was a recent infection — suggesting the outbreak is still going on — or whether the person was infected years ago.»
Unbeknownst to Knight's team at the time, the infant staying
in that room had had a
lung infection with that
bacterium.
«This is critical
in removing
bacteria from sequestered spaces
in the
lung,» he says.
The team has now also tested the
bacteria on a woman with tumours
in her liver,
lungs and soft tissue that didn't respond to standard treatment.
In cystic fibrosis, a serious genetic disease that causes recurring lung infections, bacteria colonize a patient's lungs, usually beginning in childhood, leading to difficulty breathin
In cystic fibrosis, a serious genetic disease that causes recurring
lung infections,
bacteria colonize a patient's
lungs, usually beginning
in childhood, leading to difficulty breathin
in childhood, leading to difficulty breathing.
Three days later, the scientists discovered that although the mice had cleared the
bacteria from their livers,
lungs, and spleens, the tumorous tissue
in their colons was crawling with Salmonella.
Others note that the ability to re-create conditions closer to the sputum
in the
lung of a CF patient will lead to better understanding of how different strains of the
bacterium behave.
They reprogrammed E. coli to sense Pseudomonas aeruginosa — a
bacteria that can form biofilms and causes hospital - acquired infections
in the
lungs and the gut.
One of the most dangerous of these
bacteria is P. aeruginosa, which, within the unique mucus that forms
in the
lungs of a person with cystic fibrosis, develops into large, antibiotic - resistant colonies.
Marvin Whiteley, a professor of molecular biosciences, and his research team at The University of Texas at Austin explain
in the paper how they applied new technology to
bacteria thriving
in actual samples of the mucus from CF
lungs to model the behavior of the
bacterium in that environment.
Experiments that model the
bacteria in animal cells, for example, have shown that P. aeruginosa behaves and grows
in certain ways only when it is
in the infected
lungs of a person with CF.
The researchers» report appears
in the journal ACS Synthetic Biology and describes development of this new type of E. coli that can even kill off slimy groups of
bacteria called biofilms that are responsible for many hard - to - treat infections, such as those that take hold
in the
lungs, the bladder and on implanted medical devices.
By using molecular genetic tools to reduce the amount of PC
in human
lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies
in soft agar (a gelatinous material specifically used to grow
bacteria and other cells), and a reduced rate of tumor growth
in mice.
These opportunistic
bacteria can grow on hospital surfaces or
in lungs and tissues.
These proteins aid
in marking
bacteria invading the
lung for destruction by the immune system.
The researchers also checked for the
bacteria in two
lung transplant recipients who had hyperammonemia but were still alive.
Instead, they detected a different
bacterium, Ureaplasma urealyticum,
in the man's blood and
in samples from his bladder, spleen, liver, and
lungs.
In less than five minutes, Ingber, the institute's 56 - year - old director, has pointed out a mattress that could prevent life - threatening sleep apnea in newborns; simulated lungs, intestines, and hearts made of silicone rubber using microchip manufacturing technology; and a machine that forces mutations in bacteria, directing their evolution so they can produce low - cost biofuels and drug
In less than five minutes, Ingber, the institute's 56 - year - old director, has pointed out a mattress that could prevent life - threatening sleep apnea
in newborns; simulated lungs, intestines, and hearts made of silicone rubber using microchip manufacturing technology; and a machine that forces mutations in bacteria, directing their evolution so they can produce low - cost biofuels and drug
in newborns; simulated
lungs, intestines, and hearts made of silicone rubber using microchip manufacturing technology; and a machine that forces mutations
in bacteria, directing their evolution so they can produce low - cost biofuels and drug
in bacteria, directing their evolution so they can produce low - cost biofuels and drugs.
The goal is to find new ways to tackle the disease, which requires a thorough understanding of how the
bacterium, known as Mycobacterium tuberculosis, behaves once it takes hold of the macrophages
in our
lungs.
Dental plaque may be the best - known example of a biofilm, but these slimy aggregates of
bacteria also play major roles
in such chronic infections as those
in the urinary tract or
in the
lungs in cystic fibrosis patients.
Nontuberculous mycobacteria (NTM) include more than 150 types of
bacteria, found
in water and soil, that can infect the
lungs when inhaled.
The
bacterium that causes tuberculosis, Mycobacterium tuberculosis, or Mtb, previously was thought to infect the body only through inhalation and subsequent infection of cells
in the
lungs.
Gallo speculates that
bacteria may be also help regulate inflammation
in other areas of the body such as the lining of the
lungs and nose, although different species of friendly
bacteria may be responsible.
Female
lung host defense cells were also better at killing this and other
bacteria (Escherichia coli and Staphylococcus aureus) when tested
in vitro.
The reduced numbers of
bacteria and white blood cells resulted
in less
lung damage
in the older mice who received extra vitamin E.
«Earlier studies have shown that vitamin E can help regulate the aging body's immune system, but our present research is the first study to demonstrate that dietary vitamin E regulates neutrophil entry into the
lungs in mice, and so dramatically reduces inflammation, and helps fight off infection by this common type of
bacteria,» said first author Elsa N. Bou Ghanem, Ph.D., postdoctoral scholar
in the department of molecular biology and microbiology at Tufts University School of Medicine (TUSM).
pneumonia A
lung disease
in which infection by a virus or
bacterium causes inflammation and tissue damage.
When you breathe
in bacteria or viruses, those pathogens — or germs — stick to the mucus
in your
lungs.