A study led by Dr. Nicholas Harmer, Senior Lecturer in Structural Biochemistry at the University of Exeter, published today in the journal Chemistry and Biology, provides new information about the way
bacterial cells build up a defensive sugar coating and how that process can be interrupted.
Not exact matches
Last week, genomics pioneer Craig Venter announced that his team has passed an important milestone in its efforts to create a
bacterial cell whose genome is entirely synthetic — constructed chemically from the
building blocks of DNA.
But while Venter's synthetic genome will be housed within an existing
bacterial cell, other scientists are aiming for the even more ambitious target of
building an entire living
cell from the basic chemical ingredients.
Biofilms are made up of the
bacterial cells as well as all sorts of other material — carbohydrates, proteins, and so on — that the bacteria
build to protect themselves.
When levels of arbitrium
build up — after a large number of
cells have died — phages stop killing off the remaining bacteria and retreat to lie dormant in
bacterial genomes instead.
But the crystal that Zhong and colleagues
built is only about 10 micrometers long and 0.7 micrometers wide — about as wide as a
bacterial cell.
Bacteria expressing enzyme in one
cell (bright green), while genetically identical
cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty
bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with resistance to antibiotics
built right into their genes.
Specifically, the researchers noted that the
cell wall of strep is composed primarily of a single molecule known as the group A carbohydrate (or GAC) which, in turn, is
built from repeating units of the
bacterial sugar rhamnose and the human - like sugar N - acetylglucosamine (GlcNAc).
Scientists today announced that they have crafted a
bacterial genome from scratch, moving one step closer to creating entirely synthetic life forms — living
cells designed and
built by humans to carry out a diverse set of tasks ranging from manufacturing biofuels to sequestering carbon dioxide.
Earlier this year, a team led by microbiologist Ry Young of Texas A&M University in College Station showed that an especially tiny type of phage blocks a
bacterial enzyme that
builds cell walls.
In May 2010, the J. Craig Venter Institute announced that its lab had
built the first synthetic, self - replicating
bacterial cell — that is, researchers inserted a synthetic genome, which did not exactly match the DNA sequence of any natural genome, into an existing working
cell; the
cell accepted the synthetic genome and reproduced.
Normally the electrons
build up or break down minerals in rock, but the system can also be used to clean up toxic heavy metals or to run a
bacterial fuel
cell.
It uses a spoon - like device called a tongue cleaner (although you could also simply use a spoon) to scrape the overnight accumulation of
bacterial build - up, food debris, fungi, and dead
cells from the surface of the tongue.