When microbiomes are studied using metagenomics — sequencing their total DNA — differences in
bacterial genome size can bias the estimation of the proportion of each gene in the sample.
Not exact matches
The cost difference is due, in part, to the smaller scale of the MyMicrobes operation, and in part to the
size of the
bacterial genome, which Bork says contains around 5 billion letters of DNA, compared to the 3.3 billion in the human
genome.
The tag - team relationship and the tiny
size of the Tremblaya
genome suggest each
bacterial partner has lost some of its genes and their corresponding functions over evolutionary history.
Besides influencing the function of the microbiome, changes in
bacterial genes also affect total
genome size, which can bias the estimation of the proportion of each gene in the sample.