Jeremy Lakey, Professor of Structural Biochemistry at Newcastle University who led the study explains: «Our model of
the bacterial outer membrane can be used as a simulator to test how antibiotic molecules can be made to cross this critical barrier.
I discovered that hopanoids interact with glycolipids in
bacterial outer membranes to form a highly ordered bilayer in a manner analogous to the interaction of sterols with sphingolipids in eukaryotic plasma membranes (Saenz et al., 2015).
Not exact matches
They also showed that the cephalosporinases are exported out of the
bacterial cells, attached to the surface of special packages called
outer membrane vesicles (OMVs).
GLIC has several large sub-units that lie outside the
bacterial membrane in the
outer part of the cell.
As a part of the innate immune system, Cd14 helps the body respond to
bacterial infections by producing a protein that binds to lipopolysaccharides within the
outer membranes of some bacteria.
This work zeroes in on trying to stop construction of a
bacterial cell layer called peptidoglycan, a mesh - like structure that, in gram - negative bacteria like E. coli, rests between the inner and
outer cell
membranes.
Results: A recent study of the contaminant - reducing bacterium Shewanella oneidensis provides the first evidence that the microbe maneuvers proteins within the
bacterial cell into its
outer membrane to contact metal directly.
The decreased protection in IgG1 - deficient mice correlates with less efficient
bacterial opsonization and uptake by macrophages, and this reflects the low binding of
outer membrane protein OmpD - specific IgG2a to the
bacterial surface.