Sentences with phrase «bacterial phages»

Not exact matches

Patients in danger of dying from uncontrollable bacterial infections could find new allies: killer viruses known as phages.

«We can sequence a phage quickly and say, this is the exact DNA sequence we want,» says Paul Grint, CEO of AmpliPhi Biosciences, a startup that is concocting combinations of phages in advance to treat bacterial infections like Staphylococcus aureus.

Researchers are training the system to learn how to pick out phages that can infect a specific bacterial strain.

Phages identify and grab bacteria using proteins on their leglike tail fibers, which form a strong bond with compounds on the bacterial cell surface.

Fischetti and his colleagues used a phage - encoded molecule to identify a bacterial target enzyme called 2 - epimerase, which is used by Bacillus anthracis to synthesize an essential cell wall structure.

To test the viability of these sequences, the investigators selected one of the 181 bacterial genomes, and found that they were able to induce one of several phage sequences within that genome to reproduce.

The tailspike protein (TSP) of Salmonella typhimurium phage P22 is a part of the apparatus by which the phage attaches to the bacterial host and hydrolyzes the O antigen.

When levels of arbitrium build up — after a large number of cells have died — phages stop killing off the remaining bacteria and retreat to lie dormant in bacterial genomes instead.

Phage therapy, which exploits the ability of certain viruses to infect and replicate within bacteria, shows promise for treating antibiotic - resistant bacterial infections.

«Phage treatment was effective in inhibiting bacterial growth in food, while the number of phages in the food grew, indicating that phages infect bacteria and grow in them also when refrigerated,» says Skurnik.

In this case as well, the phages effectively inhibited bacterial growth.

Since phages have evolved with their bacterial targets for billions of years, they could solve the problem of antibiotic resistance for good; the downside is that each bacterial strain requires its own tailored phage cocktail, so it could be many years before doctors have a suitably broad range of phages at their disposal.

Research focused on the utilisation of viruses that infect and kill bacteria, known as bacteriophages or phages, in preventing infectious diseases has gained new traction after bacterial resistance to antibiotics has become a global problem.

Further down the line, he says, this could be harnessed for personal phage therapy, where specially designed bacteriophages can be inserted into the gut to kill or boost certain bacterial populations that have gone awry.

Once the bacterial hosts are gone, the phages will also die, Leverentz explains.

They found that the phages from antibiotic - treated mice carried significantly higher numbers of bacterial drug - resistance genes than they would have carried by chance.

She explained that phages outnumber their bacterial prey by a factor of 10 to 1, and that they have been proposed as the agents of change in recipients of faecal microbiota transplantations used to treat resistant or recurring bowel disease.

Earlier this year, a team led by microbiologist Ry Young of Texas A&M University in College Station showed that an especially tiny type of phage blocks a bacterial enzyme that builds cell walls.

The phages infiltrate bacterial cells, where they commandeer the host machinery to make thousands of new phages; then they escape through the bacterial cell wall — killing the host — and spread to infect their next victims.

Also, phages evolve with the host and have the potential to overcome bacterial resistance, said coauthor Jochen Klumpp of the Institute of Food, Nutrition and Health, ETH Zurich.

Oral phage therapy has demonstrated to be a feasible and effective tool in the control of infections caused by different bacterial pathogens.

Rapidly changing viromes would have signaled an «arms race» in which threatened bacteria were adapting to survive phage attacks, and the phages were adapting to avoid bacterial defenses.

Based on the genetic blueprint, these bacterial cells then produce all the components of the desired phage and ensure that the virus particles are assembled correctly.

This enables scientists to genetically modify phage genomes systematically, provide them with additional functionality, and finally reactivate them in a bacterial «surrogate» — a cell - wall deficient Listeria cell, or L - form.

Phages, shown here surrounding and attacking a bacterial cell, are part of a newly discovered type of immunity that protects mucus - covered human tissue from bacterial infection.

Phage elements, including those not integrated into chromosomes, are part of a bacterial system for regulating genes.

Their activity outside the chromosomes has been poorly studied; most research has focused on phages integrated into bacterial chromosomes.

For instance, some of these phage elements can activate or silence bacterial genes by moving into or out of the chromosome.

For example, specially targeted phages have been suggested as a possible therapy for conditions like cystic fibrosis, which is caused by frequent bacterial lung infections.

These phages and plasmids can easily move between bacterial cells, and scientists have known for some time that, as a result, these so - called mobile genetic elements can play important roles in virulence and antibiotic resistance.

A new technique allows researchers to examine pieces of often - overlooked DNA outside bacterial chromosomes, including viruses known as phages (as shown above), which may play a role in disease.

The impact of the microbiota on bone marrow transplantation in mice, differences in phage infection efficiency in nearly identical hosts, bacterial diversity of Brazilian artisanal cheese.

If you can help identify some phages that are active against his (bacterial) isolate, I'll give it a whirl.»

Plasmids survive despite their cost and male - specific - phages due to heterogeneity of bacterial populations.

In his PhD thesis presented in 1958, Arber showed that in the specialized transducing Lambda phages several viral genes had been substituted by bacterial genes for galactose fermentation.

Young's research focuses on bacterial viruses, also known as bacteriophage or phage.