Sentences with phrase «barrier endothelial cells»

Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood — brain barrier endothelial cells.

Another approach might be to selectively remove CD11b leukocytes from the blood circulation so that they are not available to adhere to the blood - nerve barrier endothelial cells in patient's nerves.

This showed leukocytes crossing between the blood - nerve barrier endothelial cells without gaps in the barrier or change in how the barrier is structured.

Did the leukocytes push through or between the blood - nerve barrier endothelial cells?»

Not exact matches

The blood - brain barrier is a layer of tightly packed endothelial cells and connective cells called astrocytes that strictly regulates the flow of chemicals in and out of the brain.

«This new chip enables us to perform live electrophysiological measurements to assess the integrity of the endothelial barrier in the heart using TEER measurements, while simultaneously quantifying the beating frequency of the heart cells using MEA.

Sydenham chorea was like rheumatic fever of the brain, thought to occur when rheumatic fever progresses and strep antibodies (emboldened by fever) breaches the blood - brain barrier (BBB), the tight wall of endothelial cells ordinarily there to protect the brain from the outside world.

Specifically, the study — reported online in The Journal of Infectious Diseases — shows that E. coli K1 modulates the protein peroxisome proliferator - activated receptor - gamma (PPAR - γ) and glucose transporter - 1 (GLUT - 1) levels at the blood - brain barrier in human brain microvascular endothelial cells.

To make their molecular delivery vehicles, the researchers combined the polymersomes with a protein called LRP1, which is abundant in the endothelial cells that make up the blood — brain barrier wall.

Within the blood vessels of the brain, endothelial cells and other adjacent cells form a tight barrier that helps to prevent toxins and microbes from entering the brain.

An impermeable shield of endothelial cells that protects our brains from toxins and other threats that may lurk in circulating blood, the barrier can also exclude therapeutic drugs and, at times, essential biomolecules required for healthy brain development.

To study this barrier and determine why a lack of blood flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting of a channel lined with a layer of human endothelial cells surrounded by extracellular matrix within a microfluidic device, which allowed them to easily simulate and control the flow of blood through a vessel and evaluate the cells» responses.

The transplanted stem cells had differentiated into endothelial cells — which form the inner lining of a blood vessel, providing a barrier between blood and spinal cord tissue — and attached to capillaries in the spinal cord.

Key elements of the immune system, they also have the ability to turn into several cell types after having passed the endothelial barrier, in order to fulfil different functions depending on the tissue.

In human endothelial cell monolayers in culture, NS1 from any of the four DENV serotypes triggered endothelial barrier permeability.

The endothelial cells have a receptor for transferrin that acts like a gatekeeper: When transferrin binds to a receptor on the blood side of the barrier, the endothelial cell transports it (and its iron cargo) to the other side and spits it out into the brain.

Genentech scientists led by Mark Dennis designed an antibody with two arms — one that binds to BACE1 and inhibits its activity and one that binds to the transferrin receptor and tricks endothelial cells into transporting the antibody across the blood - brain barrier.

We also demonstrate that NS1 from DENV1, DENV2, DENV3, and DENV4 triggers endothelial barrier dysfunction, causing increased permeability of human endothelial cell monolayers in vitro.

It took advantage of the brain's own mechanism for getting a necessary nutrient, iron, across the lining of endothelial cells that form the blood - brain barrier.

TNF - alpha and VEGF have proven to be particularly effective: TNF - alpha allows adhesion to endothelial cells, while VEGF authorizes the passage through the endothelial barrier.

Specific Binding, Uptake, and Transport of ICAM -1-Targeted Nanocarriers Across Endothelial and Subendothelial Cell Components of the Blood — Brain Barrier.

Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye, Genentech Lymphangiogenesis and lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University

Lethal factor directly effects endothelial and epithelial cells to reduce barrier integrity during infection [5].

The SPG cell layer, which is adjacent to the neurons of the brain, forms septate junctions, which function as a barrier to separate the humoral space and the brain, analogously to the mammalian tight junctions formed between endothelial cells.

By culturing RBECs and human endothelial cells under flow conditions, the researchers found that cell - cell junctions they formed accurately mimicked endothelial barrier formation in the brain.

B. anthracis secretes lethal toxin, which contributes to barrier disruption via interference of epithelial, endothelial and immune cell function [5].

The blood brain barrier (BBB) is a physical barrier formed by the arrangement of endothelial cells and tight junctions that line the capillaries which supply blood to the brain.