Sentences with phrase «basal tumor subtype»
«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.
https://www.sciencedaily.com/ Not exact matches
Human breast cancers can be classified according to their histological and molecular features into different subtypes, including luminal, ERBB2 and basal - like tumors.
Tumor recurrence was faster and more likely among African American patients, particularly for basal subtype tumors or those driven by the TP53 mutation.
The number of mutations within each tumor and the prevalence of the basal - like and mesenchymal stem - like subtypes — all of which suggest more aggressive tumors — was also greater in the tumors of African American patients.
The Cancer Genome Atlas study encompasses more than 500 primary tumors representing the four intrinsic subtypes of breast cancer: Luminal A, Luminal B, Her2 - enriched, and Basal - like.
Among these and other results integrating multiple platforms, it's apparent that Basal subtype tumors more closely resemble ovarian tumors than other breast cancer subtypes.