Sentences with phrase «base changes known»

These letters are involved in single - base changes known to regularly cause disease in humans.

Not exact matches

Polish scientists have shown that male and female preferences for a height difference (known scientifically as sexual dimorphism) change based on how tall they are, perhaps so that people can widen their own dating pool.

Most people are wary of change, and know that new technologies take time to learn and stabilize, so customers prefer solutions based on tried - and - tested proven technologies.

The settlement also stipulates that the San Diego - based chip maker implement policy changes and programs to better promote female employees working in the field of science, technology, engineering and mathematics, known as STEM.

Part of the reason is likely that Canada is a big country with diverse weather patterns that change often, so we need to know how to prepare on a daily basis.

The advance is based on a technique that allows scientists to narrow in on a specific gene and cut - and - paste bits of DNA to change its function, known as CRISPR - Cas9.

They know when there's a lot of chatter about a topic that affects their business, and they aren't afraid to consider changes based on customer desires.

Experienced businesspeople know you will face stiff competition: showing you understand your competition, understand your strengths and weaknesses relative to that competition, and that you understand you will have to adapt and change based on that competition, is critical.

At this point, health care is one issue I have chosen to deal with on a year - to - year basis, while also knowing that future changes might require us to work longer than we'd hoped.

To be alerted of sudden changes to our market timing model (a rule - based strategy of knowing when and how aggressive to be in the market), and to receive our best nightly stock and ETF picks, sign up now for your 30 - day risk - free subscription to our swing trading newsletter.

Lawmakers have been calling for Social Security to base its cost of living adjustments on changes in what's known as the chained CPI.

This is known as the cost - of - living adjustment, or COLA, and is based on changes in the consumer price index (CPI).

And they know that relationship - based, «structural» trust changes depending on where people stand on the organizational map.

«We try very hard as policymakers to diversify the economy, but no matter what, our base is one - third tourism, and it never really changes.»

The government intended to sell its tax changes for CCPCs on the basis that they would mean higher income Canadians would no longer be able to avoid paying their fair share of tax.

The explanation provided was that as a «result of accounting changes due to the Jobs and Economic Action Plan, public debt charge forecasts from the Federal Budget are no longer a reasonable estimate of cash - basis expenditures for reporting in the Estimates» [5].

The Butterfly Effect is a theory that is based on a single occurrence that can profoundly change the course of events; no matter how insignificant that occurrence is perceived to be.

We know foreign sector accumulation of Treasuries is slowing meaningfully on a rate of change basis (48 %).

What we do know today is that traditional methods of structured customer, buyer, and market research that are quantitative based can not address the social and cultural changes taking place in our business society.

[4] As a result, changes in the monetary base are no longer «high powered» — the money multiplier has collapsed and the monetary transmission mechanism that prevailed prior to 2008 is broken.

Use language appropriate to the visitor based on the target audience Heat maps show an F pattern is used when scanning content, so using bold headings and sub-headings to make it easier to scan and break up a copy Change paragraphs to bulleted lists Put the main point first (inverted pyramid) Use personal pronouns Put yourself in the place of the visitor and consider questions the visitor may have, then get to the point with the answer Add links, if appropriate, to keep the visitor engaged on your site and to keep them from searching elsewhere Name links (and anchor text) in a way that the visitor will know what to expect when they click Find out what keywords visitors are searching for to reach your site and write with these keywords in mind These tips are a great starting point for anyone wanting to optimize their website content.

No, Darwin's evolution by natural selection was most certainly not based upon merely seeing some bacteria change in a petri dish, and leaping directly to humans and apes having common ancestors.

If you understood science you would understand that science understands principles to a known degree of statistical certainty, is subject to change based upon new information.

If the prayer group in the experiment suddenly, in controvention of known medical timelines, demonstrated that they were as they were prior to the diesease, surgery, injury etc, and subsequent testing provides no evidence of anything other than a straight up non medical intervention based change in their biology, THEN the results might be remarkable.

The change that has come about in theologies that partake of creative and emergent evolution can be described in this way: since mechanism is no longer the base of their evolutionary thinking, idealism is no longer essential as a strategy of thought in resolving the tension between science and faith.

Islam was driven into expansions outer boarder came after the death of the Messenger of God and only went to outer the Arabian Penisular towards the Arabic countries boarders now because of the wars launched on their boarders by the Roman Empire before changing face when a new Religion was imposed that combined all Beliefs that was within it into one state religion based on which The Roman Armies became to be known there after as the Crusaders whom launched attacks by land or by sea on Islamic countries through many generations up to date

At present, and based on what we know of the genetic regulation of development, these phenotypic changes in the gut are most likely the result of positive genetic changes in the genetic regulatory pathways controlling the development of the relevant anatomical features, i.e. they are novel positive, heritable genetic features producing a specific and functional novel anatomical structure within the Genus.

The experience radically changed him, and he's since become an advocate for what's known as the 12 - step program, an addiction recovery method based largely on Christian principles that is centered on a reliance on a higher power, self - reflection and forgiveness.

In the June 2010 issue of Nature Medicine, in an interview with theBoston - based researcher, Daley tells how he further changed the focus of his work after Prof. Shinya Yamanaka of Kyoto University, who won the 2010 Kyoto Prize for advanced technology, made known his successes with iPS cells in 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he says.

It is based on what man knows to be at the time, but as I said, even theories based on «facts» has been proven to change.

I do not know whether some sort of decentralized democratic socialism can supply a healthier economic base for the kind of change that seems necessary if we are to continue as a society of free men and women.

Based on the theorys of Science (which do change at times) how do you know that your not living in Delusions of Granduer?

I guess that little by little you can bring a little change... I know the instinct would be to remove the meat first, but the best way to start is * adding * more plant based dishes, not removing what's already there!

This is one of those that will make you rethink everything you know about food and health and will inspire you to make changes in your own life by switching to plant - based diet.

Because The Stoned Crab is known for serving some of the freshest seafood in Key West, the menu will change based on the fish caught that day.

Whether you're interested in plant - based proteins for health, environmental, or animal protection reasons, any change, no matter how small, can make a big impact.

Given the Massachusetts - based brand's health halo, CEO Sal Rincione knew it was time for him to make some lifestyle changes.

Now that you know your wood sorrel from your sea buckthorn, it's time to get on a first - name basis with yet another game - changing Scandinavian chef: Christian, as in Christian Puglisi, the Sicilian - born, Danish - reared mind behind the Michelin - starred Relæ and Manfreds & Vin.

I know that Arsenal are in a strong state, financially speaking but at the same time I do not think that our manager and board are about to change the way they work, which is fundamentally based on balancing the books and operating on a sound business footing rather than being a rich man's plaything like some clubs in the Premier League and around Europe seem to be.

A club run by joe Lewis lol when was the last fuking time Spurs won a trophy give it a fuking rest Wenger has won more trophies then spuds in their whole fuking history Sick of plastic fans constantly knocking the manager and players like you are fuking genius experts in knowing all about football We have the worst fan base in football a bunch of ingrates Why would any top player come and join Arsenal when they see how fans treat their own players like ozil Lol at people talking about Spurs and pool fukers don't win any trophies but their fans stay loyal ours turn nasty every game werther we win or lose It won't change even if we get a new manager they will turn on him at first defeat What we need is for the vocal minority of plastic key board fans to fuk off and stop bringing the club down Coyg

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Below are my guesses, based on an offseason of reading Bill Connelly's team previews and lots of other stuff, then going through each FBS team's schedule, game by game — I picked your team to beat your biggest rival — and then being unhappy with LSU's record, no matter how much I changed it.

Basically pending any changes we know who 14 of the 16 home and away games are against until the end of time based on the rotation.

On this basis, given the fact that the agents know everything, I would suggest this summer, (subject to us not winning the Europa League) will finally bring about a change of manager and the incoming manager will be of a European winning pedigree....

No, he needs to fundamentally change what the analogy is based on.

Secondly, Wenger needs to become far more flexible when it comes to his formation selections... remember this is the same individual that hadn't used a 3 - back system for 20 years and only conceded to the experiment when the proverbial shit hit the fan... you know it killed him to adopt «Conte's» system, which is probably why he resisted so long; in fact his stubbornness to adjust even earlier might have cost us the 4 hole... much like most sports that have tactical formations, every team should have a «base» offensive and defensive scheme, but they likewise need to have some inherent flexibility depending on the opposing teams tactics and / or when specific substitutions are made... how many times have you watched a Wenger - run team make a late substitution but not change their shape on the pitch... furthermore, how many times have you seen our team fail to make the necessary adjustments at halftime due to Wenger's tactical stubbronness, which often led to giving up goals in the early minutes of the second - half... the best teams in the world know how to make halftime adjustments whereas we always seem to be surprised when the opposing team throws a wrinkle into the mix following halftime... this my friend is soccer 101

typical, it chops and changes based around whatever your ill - informed negative rant will be based on for the day... The key to a successful squad is having squad players who can support the first - team and fill in throughout parts of the season without needing a few games to get in form and know their place.

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

there was no doubt in my mind, based on the contractual activities of the summer that Ox and Bellerin would need to see the field on Day 1, unfortunately this meant Ox would be placed in an uncomfortable position on the left... this can't be the plan moving forward, so either they share the right wing - back position or a formation change is needed if both are going to be in the starting 11... strangely enough Bellerin looked far more comfortable than Ox on the left, albeit a smaller sample size

Graham I don't know you and in bloggers world we can only form an opinion on someone based on how they portray their comments, but I see you as a blogger that has made his mind up so long ago and has drawn a line under it, and that there is no room for change of opinion or a more considered viewpoint anymore looking at issues from different angles.