Sentences with phrase «base pair regions»

Previous work had shown that TFIIH is unnecessary if the DNA has a 12 base pair region that is already opened.

We examine here using high - density oligonucleotide array the state of DNA methylation, histone acetylation and gene expression in a 7 million base pair region of chromosome 18 containing the NR3C1 gene in the hippocampus of adult rats.

Not exact matches

The announcement on hydrofracking, paired with Southern Tier - based projects being shut out, was seen as a serious morale blow to the region, with the Binghamton Press and Sun summing up the day with the word «NO» on its front page.

This permits high - resolution mapping of genes and chromosomal regions on single fibers of DNA, and it targets the physical location of mitochondrial DNA probes down to a resolution of 1,000 base pairs.

The DNA of the bithorax complex has been isolated, and a region of 195,000 base pairs that covers the left half of the complex is described here.

The team members narrowed their search to a region of about 1 million base pairs on chromosome 1.

«They can be several thousand base pairs long, whereas in most organisms those regions may be only a couple hundred base pairs long,» he said of the untranslated regions.

King's team has narrowed the hunt to a region of just 300 000 base pairs on the chromosome.

Often, these regions are large, covering millions of base - pairs and do not shed light on the specific mutations that are responding to the selection pressure.

But genes in other regions are so close together they overlap: the cluster of 75 genes which determines tissue type and plays a part in controlling our immune responses is packed into only 4 million base pairs.

A September 2008 study in Nature confirmed earlier findings suggesting that 30 percent of people who have a deleted length of three million base pairs in a region of chromosome 22 suffer from psychiatric conditions such as autism and schizophrenia.

And in January 2009 another Nature Genetics paper found an association between high body mass index and a 45,000 base - pair deletion in a gene called NEGR1, which affects neuronal growth in the hypothalamus, a brain region that regulates hunger and metabolism.

A Nature Genetics study from August 2008 found a link between Crohn's disease and a 20,000 base - pair deletion in a region upstream of a gene called IRGM, which is involved in fighting invasive bacteria.

It scans a very broad area of the genome (508 genes and more than two million base pairs or letters of the genome, i.e.. A, T, C, and G) with high accuracy (each region of the genome is sequenced or «read» 60,000 times), yielding about 100 times more data than other sequencing approaches.

(The team doesn't yet understand why, because the changed base pair lies in a region that is not translated into RNA and is not usually involved in switching genes on and off.)

These markers allowed the group to narrow the suspect region of the chromosome to a 6 - million - base - pair stretch of DNA that turned out to contain a promising gene: the - synuclein gene.

But the newly identified virus, known as the Cafeteria roenbergensis virus, is a pack rat: It lugs around a staggering 730,000 base pairs of DNA, including more than 500 gene - like regions, researchers report online today in the Proceedings of the National Academy of Sciences.

To identify segments across the intronic and exonic regions of the BRCA1 or BRCA2 genes associated with different breast vs ovarian cancer risks, we created bins of mutations by base pair location (Figure 1).

As a first step, they used shotgun sequencing to sequence a 32,000 - base - pair region of the finch's genome.

It is possible to identify regions of similarity, insertions and rearrangements at any level from the whole genome to base - pair differences.

We modeled the secondary structure of rRNA using principles of compensatory base changes — where base - pairing in hairpin stem regions would be retained even if the sequence changes — and we found that there was a core structure that was conserved between Xenopus, yeast, and E. coli.

The mode of action of the mature miRNA in mammalian systems is dependent on complementary base pairing primarily to the 3» UTR region of the target mRNA, thereafter causing the inhibition of translation and / or the degradation of the mRNA.

Even more astonishing are the 6 + million coding variants: depending on how you define the exome, that's about one variant every 5 or 6 base pairs in coding regions.

«Previous studies had identified broader regions of chromosomes that were involved in sexual orientation, but we were able to define these areas down to the base pair level with our approach,» Dr. Ngun said.

The lesson includes: - Starter - Revision of the core vocabulary from the previous lesson - A simple reading worksheet on Belgium - A reading worksheet on the region of Brittany - A paired dictation activity designed to practise using the core vocabulary in sentences - A link to a video of Brittany to provoke discussion - A postcard activity based on a visit to Brittany - A worksheet to practise the core vocabulary with translation into and from French - Page 79 Speaking exercise 4 - Page 79 Reading exercise 5 with answers - Page 79 Writing exercise 6 - Plenary

The pair have also been active in Switzerland and Austria — Skadden has operated a base in Vienna since 1993 — while Simpson says that Finnish - national Kaulamo will assist with the firm's activities in the Nordic region.

The heart of the innovation, as I understand it, lies in the choice of a particular and small region of DNA shared by many animals; to say it in technical terms: it's «a 648 base - pair region in the mitochondrial cytochrome c oxidase 1 gene («CO1»).»

One of these is a variable number 48 base pair tandem repeat (48 bp VNTR) in the coding region of the gene [89].