Sentences with phrase «base substitutions»
"Base substitutions" refer to a type of genetic mutation where one DNA base (adenine, guanine, cytosine, or thymine) is replaced by another during the replication or copying process. This change in the sequence of bases can alter the instructions that the DNA carries, potentially leading to changes in traits or characteristics. Full definition
That's because base editing is significantly more efficient than standard CRISPR at making single base substitutions.
cen.acs.org
In it, the authors review bioinformatics approaches for evaluating single - base substitutions in both coding and noncoding regions, with an emphasis on large cancer resequencing efforts including the Tumor Sequencing Project, the Cancer Genome Atlas (TCGA), and the AML1 cancer genome.
The accuracy of next - generation sequencing (NGS) for detecting tumor - specific mutations in plasma DNA is hindered by errors introduced during PCR / sequencing, base substitutions caused by DNA damage, and pre-existing mutations in normal cells that are present at a low frequency.
will make a great base substitution for the sauce — just adjust the seasonings to accommodate the lack of flavor tahini provides.
But in the US this decrease occurred not through government intervention but through market - based substitution of natural gas - fired plants for coal plants because of increased use of fracking and other new techniques in finding additional natural gas.
BROCA detects all single base substitutions, insertions and deletions and copy number variants in all 24 genes implicated in breast cancer.
SV40 mutants with small deletions or base substitutions have been isolated by in vitro site - specific or random local mutagenesis of recombinant DNA followed by cloning in E. coli.
Occasional inserts, like the famous shot of Walter Huston doing a jig at 31:30, are for whatever reason unnaturally blurry, like an optical blowup or a video - based substitution, but they are thankfully few and far between.