Sentences with phrase «based human protein»

The study's network modeling approach relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Not exact matches

• Proteintech Group, acquired HumanZyme, a Chicago - based manufacturer of recombinant human proteins.

While protein products developed by these companies are not currently fit for human consumption, methane - based proteins could improve the environmental impact of meat production, and eventually further fuel the meatless revolution by creating another food source for developing economies in Africa and Asia.

I also made a some protein packed snacks for the family, as protein is the most difficult nutriotional source we, as humans, have trouble getting enough of on a daily basis.

Actually, formula ingredients are made by modifying cow's milk - based protein and adding a milk sugar (lactose), fats, vitamins, and minerals to mimic the components of human milk.

The vast majority of babies fed a human milk substitute are given modified cow milk or soy protein - based formula.

Then a team of Chinese researchers used that base editor to correct a mutation in human embryos that causes the blood disorder beta - thalassemia, reported September 23 in Protein & Cell (SN: 11/25/17, p. 7).

Building the knowledge base requires humans to teach computers key concepts from curated articles; with modest online training, anyone who reads English can scan research papers for key terms — names of genes, proteins, diseases, and drugs — and use online marking tools to document relationships between them (for example, drug X treats disease Y).

The new strategy is based on human RNA - binding proteins that normally help guide embryonic development.

Approaches based on these five strategies have been used for streamlined, enhanced validation of more than 10,000 antibodies from more than 30 providers, targeting over 7,000 human proteins as part of the Human Protein Atlas prohuman proteins as part of the Human Protein Atlas proHuman Protein Atlas program.

The findings also point to the potential for new therapies for lupus and other autoimmune disease based on inhibiting the action of EBNA2 or other human proteins that bind to DNA at the same loci along with the viral protein, the researchers say.

Based on this link, Shaw tested the activity of other immune proteins in humans to see if any changed after sleep loss.

A decade on from the completion of the Human Genome, the Human Protein Atlas, a multinational research project supported by the non-profit Knut and Alice Wallenberg Foundation, recently launched (November 6, 2014) an open source tissue - based interactive map of the human protHuman Genome, the Human Protein Atlas, a multinational research project supported by the non-profit Knut and Alice Wallenberg Foundation, recently launched (November 6, 2014) an open source tissue - based interactive map of the human protHuman Protein Atlas, a multinational research project supported by the non-profit Knut and Alice Wallenberg Foundation, recently launched (November 6, 2014) an open source tissue - based interactive map of the human prothuman proteome.

The researchers used a technique called activity - based protein profiling, which allowed them to screen the molecule's activity against a very large group of enzymes in living human cells.

Their system, adapted from technology they previously developed and commercialized through U.K. - based CN BioInnovations, also incorporates several on - board pumps that can control the flow of liquid between the «organs,» replicating the circulation of blood, immune cells, and proteins through the human body.

In February, U.K. — based Orthomimetics began a human trial of one such implant, built from the protein collagen (a building block of many body tissues) and the mineral calcium phosphate (found in bone).

Based on bacterial genes, the team identified a human protein, selenium binding protein 1, which can convert methanethiol into other and compounds.

Alan J. Higgins of Icoria, a company based in Research Triangle Park, N.C., that is applying its metabonomic technology to human health, explains that «metabono - mics gives you the functional component» that is not always evident from a genetic or protein analysis.

The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the entire genome, regardless of whether these genes are expressed or silent).

Based on the observation that obese mice, rats, and humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.

In the November PLoS Medicine, the team reports the results of the first human tests of a vaccine based on the MSP3 protein.

The Monash BDI researchers worked in collaboration with Canadian - based company Kinexus, and used an antibody microarray to simultaneously investigate hundreds of factors involved in cell signalling that were modulated by HCV replication, including human protein kinases.

The 12th release of the Human Protein Atlas (HPA) covers 16,621 genes (approximately 83 % of the human protein - coding genes) and includes protein expression profiles based on 21,984 antiboHuman Protein Atlas (HPA) covers 16,621 genes (approximately 83 % of the human protein - coding genes) and includes protein expression profiles based on 21,984 antiProtein Atlas (HPA) covers 16,621 genes (approximately 83 % of the human protein - coding genes) and includes protein expression profiles based on 21,984 antibohuman protein - coding genes) and includes protein expression profiles based on 21,984 antiprotein - coding genes) and includes protein expression profiles based on 21,984 antiprotein expression profiles based on 21,984 antibodies.

Longo, who worked on the new human study, recommends that adults replace some animal proteins in their diets with more plant - based ones, such as those proteins found in beans and nuts.

This version covers 15,156 genes (approximately 75 % of human protein - coding genes) and includes protein expression profiles based on 18,707 antibodies.

Protein - based nanoparticles are ideal for drug delivery because they are compatible with human biology, are biodegradable, and have low toxicity.

In this context, Dr. Woo's work focuses on deepening the understanding of these mechanisms based on postmortem human brains and animal studies using a variety of protein and gene expression techniques, in addition to the utilization of differentiated human neurons.

Functional analysis of human microtubule - based motor proteins, the kinesins and dyneins, in mitosis / cytokinesis using RNA interference.

Mass spectrometry ‐ based cellular thermal shift assay (MS ‐ CeTSA) analysis of CDK4 / 6 inhibitor palbociclib targets in MCF7 human breast cancer cells identifies protein complexes including the 20S proteasome.

Using this approach, we performed a systematic phylogenetic and protein domain architecture - based study, encompassing the entire proteomes of all human Herpesviridae, as well as of select non-human herpesviruses, to define Strict Ortholog Groups (SOGs).

Using the new method, published on July 31, 2017 in Nature Chemistry, the TSRI scientists identified more than 100 human proteins that are likely to be targetable with small molecule, pill - based drugs.

Identifying and producing low cost molecular binders based on naturally occurring human protein.

'' The inclusion of the GTEx dataset to the Human Protein Atlas database makes it even more comprehensive and it is reassuring that there is a significant overlap in the tissue classification of the genes based on the two independent datasets.»

Biological performance of a polycaprolactone - based scaffold plus recombinant human morphogenetic protein - 2 (rhBMP - 2) in an ovine thoracic interbody fusion model (vol 23, pg 650, 2014).

The article, Tissue - based map of the human proteome, is one of 340 papers published by researchers in the Human Protein Atlas project, led by Mathias Uhlén at KTH Royal Institute of Technology / SciLifhuman proteome, is one of 340 papers published by researchers in the Human Protein Atlas project, led by Mathias Uhlén at KTH Royal Institute of Technology / SciLifHuman Protein Atlas project, led by Mathias Uhlén at KTH Royal Institute of Technology / SciLifeLab.

Importantly, the interaction networks formed between these proteins occur within regions that are highly similar to the human complex, suggesting the complexes are comparable and making this research highly relevant to understanding the molecular basis for human cancer.

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.

The Pathology Atlas also contains 5 million pathology - based images generated by the Human Protein Atlas consortium.

In the present study, the researchers have developed a mass spectrometry - based method that is sensitive and reproducible in order to measure, at steady - state conditions, absolute protein copy numbers across human tissues and cell lines and compared these levels with the corresponding mRNA levels using transcriptomics.

It is based on the scientific understanding and high - throughput analyses of human immune responses to disease - related proteins in selected populations including elderly with the capability to stay healthy during the aging process.

We are particularly interested in the identification of novel human proteins involved in inflammatory, immune and cancer processes that can not be characterized by sequence - based methods due to their low or not existing sequence similarity to others.

«A huge fraction of the human «proteome» remains uncharacterized, and this paper shows how chemical approaches can be used to uncover proteins of a given functionality that have eluded classification based on sequence or predicted structure,» said co-senior author Benjamin F. Cravatt, chair of TSRI's Department of Chemical Physiology.

The researchers analyzed hundreds of human transcription factors, which are proteins that read the genetic information coded in DNA's sequence of four nucleotide bases — adenine (A), cytosine (C), guanine (G) and thymine (T)-- and pass that on to RNA molecules.

iTeos focuses upon selected key suppressive mechanisms of immunity in cancer based on gene expression, association with immune cell subsets, protein expression in human tumors and biological validation.

Researchers describe how a bacterial infection - based protein delivery strategy can mediate effective and safe gene editing in human pluripotent stem cells.

«We are excited about the efforts to create a Human Cell Atlas and the addition of new emerging tools to create a knowledge - based platform for understanding the human cell» says Mathias Uhlen, Director of the international Human Protein Atlas consorHuman Cell Atlas and the addition of new emerging tools to create a knowledge - based platform for understanding the human cell» says Mathias Uhlen, Director of the international Human Protein Atlas consorhuman cell» says Mathias Uhlen, Director of the international Human Protein Atlas consorHuman Protein Atlas consortium.

The Human Protein Atlas project, funded by the Knut and Alice Wallenberg Foundation, has been set up to allow for a systematic exploration of the human proteome using antibody - based proteoHuman Protein Atlas project, funded by the Knut and Alice Wallenberg Foundation, has been set up to allow for a systematic exploration of the human proteome using antibody - based proteohuman proteome using antibody - based proteomics.

We have previously identified hundreds of new cell division genes by RNAi - based screening of the entire human genome and we are now studying — in live cells and with high - throughput — protein function, interactions and networks.

This initial project focused on 50 uncharacterized proteins that, based on literature searches, showed some likelihood of being associated with human disease.