Sentences with phrase «based biomarkers»

Serum - based biomarkers and GDS - 30 score and subscales of depressive symptoms were examined in a cross-sectional sample of 81 elderly men drawn from the TARCC cohort.

For the purposes of this review, blood - based biomarkers are operationalised as molecular indicators detected in blood, blood products, plasma or serum.

Blood - based biomarkers of cancer - related cognitive impairment in non-central nervous system cancer: protocol for a scoping review

ABSTRACT: Serum - based biomarkers and GDS - 30 score and subscales of depressive symptoms were examined in a cross-sectional sample of 81 elderly men drawn from the TARCC cohort.

Researchers have developed a method for identifying splicing - based biomarkers for liver cancer...

The goal of the program is to discover gene - based biomarkers that can predict outcomes, estimate treatment toxicities, speed discovery of new drugs and create a model that could be reproduced at academic medical centers across the nation.

Along these lines we will present proof of concept data for salivary DNA - methylation - and autoantibody - based biomarkers in a breast cancer patient cohort.

More investigation of brain - based biomarkers and brain imaging could help predict how patients will respond to treatments, she suggested.

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA - based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

This situation is confounded by the relative scarcity of blood - or cerebrospinal fluid (CSF)-- based biomarkers that can increase our understanding of disease pathology, and might also serve as effective differential diagnostic or prognostic tools.

The single molecule array (Simoa) technology developed by Quanterix, and the fully automated HD - 1 analyzer, offers unprecedented improvement in sensitivity proteins over current technologies for the detection of blood - based biomarkers — as much as 1000 times more sensitive than conventional immunoassays.

Our results prove adding imaging - based biomarkers that directly quantify atherosclerosis are ideal adjuncts to the current conventional CVD risk factors and these imaging biomarkers may be a true game - changer to our practice of cardiovascular medicine.»

Prior to joining Genentech in 2007, Dr. Hegde led genomics - based biomarker activities in oncology and cardiovascular diseases at GlaxoSmithKline.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

The next steps are to implement sequencing - based biomarker assays, such as reported in our study, in accredited pathology laboratories.

«The LSC17 score is the most powerful predictive and prognostic biomarker currently available for AML, and is the first stem cell - based biomarker developed in this way for any human cancer,» says Dr. Wang.

Scientists have not pinned down the syndrome's cause, although another recent PLOS One study identified a possible RNA - based biomarker for its diagnosis.

Uulm is involved in the peptidome work (WP1), lipid antigen discovery (WP1), and the lipid based biomarker work (WP5).

FlowGate: Transformative Computational Infrastructures for Cell - Based Biomarker Diagnostics

Small - world metrics can characterize the functional organization of the brain in AD, and our findings further suggest that these network measures may be useful as an imaging - based biomarker to distinguish AD from healthy aging.

The team will continue to develop and test an imaging - based biomarker that can be used in a clinical setting to enable us to understand the molecular changes to the ganglion cells, so we can detect the disease very early on.

A novel antibody - based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity.

Not exact matches

• Quanterix Corporation, a Lexington, Mass. - based company digitizing biomarker analysis, raised $ 8.5 million in funding.

ProAxsis is a diagnostics company based in Northern Ireland, developing a range of products to identify active protease biomarkers of diseases.

Peripheral inflammatory responses may, then, serve as biomarkers and thus serve as targets of immune - based therapies for depression.

In the spring, the U.S. Food and Drug Administration approved an antibody that is the first cancer therapy based on a tumor genetic biomarker instead of a location in the body.

Instead, he plans to narrow the list of useful biomarkers, then develop antibody - based tests for clinical use.

Many studies have shown serum TK1 to be a valuable cancer biomarker, but most previous assays have been enzyme - activity based and may underestimate its presence in solid tumors.

«This gives us an underlying candidate biomarker panel that provides information on the subsequent clinical outcome or therapeutic efficacy, which can be validated to yield a final panel, then translated into say, an ELISA - based kit or some other immunodiagnostic format in the clinical setting,» says Dorfman.

The UMD and UMB team, led by research associate Eunkyoung Kim, used a discovery - driven approach based on the assumptions that chemical biomarkers relating to oxidative stress could be found in blood, and that they could be measured by common electrochemical instruments.

For the study, the Johns Hopkins team set out to lower the rate at which doctors order cardiac biomarker testing for the diagnosis of acute coronary syndrome by basing the desired rate on scientific evidence.

To speed up progress in biomarker - based research, international experts have defined five sequential phases on the road to new diagnosis and therapy options:

Killary said the team is working to use the biomarkers in MD Anderson's high - risk clinic, established through MD Anderson's Pancreatic Cancer Moon Shot ™, part of the institution's Moon Shots Program ™ to accelerate the development of life - saving advances based on scientific discovery.

«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»

This study provides the basis for a biomarker to determine which patients might be best to target with new treatments.»

According to lead author Mr James Oliver of the Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, UK, «in current clinical practice, RA drugs are administered on a trial and error basis; there are no clinical biomarkers of response to guide treatment decisions.

They are investigating indoor emissions in other areas of Tibet and plan to link these measurements to a biomarker study based on blood samples of people living in the households.

The Brain Trauma Indicator, developed by San Diego — based biotechnology company Banyan Biomarkers, was reviewed and authorized for commercialization in fewer than six months.

Hariri said he hopes that other researchers looking for biomarkers of mental illness will begin to consider methylation above and beyond DNA sequence - based variation and across different tissues.

There are ongoing studies which focus on the discovery of molecular biomarkers of the VSV - ZEBOV vaccine in healthy individuals using omics - based technologies in combination with a systems biology approach,» says Ali Harandi.

«The results can also provide information to discover biomarkers for other vaccines based on living vectors.

Since the biomarker groups they investigated are based on algae — i.e., on plants that require light for photosynthesis — the absence of both groups is an important indicator of a very thick and largely contiguous ice cover.

The chemical biomarker can be detected noninvasively using technology based on magnetic resonance imaging.

In addition to illustrating the experimental role of a sucralose - maltodextrin based artificial sweetener in promoting intestinal dysbiosis [a microbial imbalance] and myeloperoxidase activity, the studies indicate that it might be possible to measure Proteobacteria and myeloperoxidase as simultaneous fecal biomarkers in patients to monitor their gut (disease / health) adjustment to their diets.

Presently there is no reliable biomarker for Parkinson's disease, either at the diseased or preclinical state, except for dopamine - based PET imaging, which is costly and requires highly specialised skills to perform.

Medical / physical outcome measures, or biomarkers, include a wide range of tools, from blood - based analyses to neurophysiological and neuroimaging methods such as eye - tracking because eye gaze abnormalities are a common feature of FXS.

Keytruda is the first approved drug that targets tumors with specific biomarkers, rather than based solely on their tissue origin (i.e. breast, lung, or colon).

Kana's multimodal neuroimaging - based classification is a step toward a possible biomarker for autism and possibly diagnosing autism at an early age, perhaps as early as 6 months, when the brain is very plastic and intervention might be more effective.

In the proof - of - principle study, Courchesne, first author Tiziano Pramparo, PhD, and colleagues identified blood - based genomic biomarkers that differentiated toddlers with ASD, ranging in age from one to four years old, from a control group of toddlers without ASD.

The legislation authorized the U.S. Food and Drug Administration to approve treatments based on biomarker data alone, and created a formal Biomarker Qualificationbiomarker data alone, and created a formal Biomarker QualificationBiomarker Qualification Program.