Sentences with phrase «based chemotherapy»

«A retrospective evaluation of doxorubicin - based chemotherapy for dogs with right atrial masses and pericardial effusion.»

For example, in working with canine lymphoma they have developed a genetic test that allows us to predict how long dogs diagnosed with lymphoma, at time of diagnosis, will respond to doxorubicin based chemotherapy.

TUESDAY, March 28, 2017 (HealthDay News)-- Zejula (niraparib) has been approved by the U.S. Food and Drug Administration to treat adult women with recurring cancers of the ovaries, fallopian tubes or abdominal wall (peritoneum) whose tumors have shrunk in response to platinum - based chemotherapy.

A total of 265 women took part in the trial, all of whom had high - grade serous ovarian cancer and had recently completed a course of platinum - based chemotherapy which had achieved a complete or partial response.

One hundred and forty patients were treated with CHOP - based chemotherapy in a historical cohort of Shanghai Ruijin Hospital from 1997 to 2011, and referred to as the training cohort.

The validation cohort consisted of 99 patients enrolled in two prospective studies (NCT 01746992 and NCT 02533700, randomized trials to compare CHOP - based chemotherapy with sequential chemotherapy with CEOP / IVE / GDP or CTOP / ITE / MTX).

Since 1995, Dr. Maharaj has been applying his academic experience and performing evidence - based chemotherapy treatment and bone marrow stem cell transplant procedures on a completely outpatient setting, with the main purpose of improving patients» safety by minimizing the risks of mortality associated with hospital - acquired infections and, ultimately, improving quality of life.

At the Maharaj Institute, our team has been treating blood cancers with evidence - based chemotherapy regimens on a totally outpatient basis; a shift in the care of these aggressive malignancies, which normally is done at the hospital.

ZEJULA is indicated for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum - based chemotherapy.

Dacarbazine - based chemotherapy as first - line treatment in noncutaneous metastatic melanoma: multicenter, retrospective analysis in Asia.

«There have been few therapeutic advances in the past 30 years and platinum - based chemotherapy remains the standard of care.

More recently, the monoclonal antibodies inotuzumab and blinatumomab have performed better than cytarabine - based chemotherapy.

In that randomized, double - blind, placebo - controlled, phase III trial, 561 patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who were in complete or partial response to platinum - based chemotherapy were treated with either rucaparib 600 mg orally twice daily (372 patients) or to placebo (189 patients).

A Phase III, Multicenter, Randomized, Placebo - Controlled Study of Atezolizumab (ANTI − PD - L1 Antibody) as Monotherapy and in Combination with Platinum - Based Chemotherapy in Patients with Untreated Locally Advanced or Metastatic Urothelial Carcinoma

The FDA granted approval to nivolumab (Opdivo), an anti-PD-1 checkpoint inhibitor, for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) that has progressed despite platinum - based chemotherapy.

The ENGOT - OV16 / NOVA trial evaluated the efficacy and safety of the PARP inhibitor niraparib as maintenance therapy in patients with recurrent ovarian cancer who respond to platinum - based chemotherapy.

«Cumulative toxicity with platinum - based chemotherapy and lack of additional benefit limits its use.

The de novo platinum resistance of this tumor subpopulation can explain why these cancers consistently reappear after first - line platinum - based chemotherapy,» the study states.

The patients all had advanced urothelial cancer that had already been treated with platinum - based chemotherapy.

KEYNOTE - 024 investigated the efficacy of pembrolizumab compared to standard of care with platinum - based chemotherapy in untreated patients with advanced NSCLC and high PD - L1 expression (defined as expression in at least 50 % of tumour cells).

Ovarian cancer is typically treated with cisplatin, a platinum - based chemotherapy.

The trial enrolled 361 patients with recurrent or metastatic head and neck squamous cell carcinoma who had not responded to platinum - based chemotherapy, a rapidly progressing form of the disease with an especially poor prognosis, said Dr. Ferris.

There a colleague of Einhorn's named Craig Nichols gaveArmstrong «almost a coin flip of a chance,» then suggested aplatinum - based chemotherapy protocol that would not compromise his lungs.Armstrong also had two lesions on his brain.

A particularly effective treatment against many cancers, platinum - based chemotherapy, has the unfortunate side effect of damaging the hair cells in the ear that are responsible for sensing sound waves, Goldrich said.

Evidence also suggests that platinum - based chemotherapies are superior therapies regardless of the patient's previous response to treatment.

Not exact matches

A patients» tumors from cholangiocarcinoma, a rare liver cancer that typically fails chemotherapy, shrunk significantly after treatment with FGFR inhibitors, which were prescribed based on results of next generation sequencing.

Based on the evolutionary idea that targeted epigenetic stochasticity can improve adaptation, these observations could explain how cancer cells are good at evading chemotherapy treatments and spreading from one part of the body to another, he adds.

«Cervical cancer patients are currently treated as a uniform group based on chemotherapy and radiation regimens that help the largest percentage of people; however, one third of these patients are not helped by standard therapies,» Banister said.

This recommendation is based on a separate study published in The Lancet, for which Garon was the senior author, showing longer survival than chemotherapy among patients with any positive staining for PD - L1.

Meanwhile, a growing arsenal of healing machines based loosely on tenuous nonlocality theories from the fringes of quantum physics have become an increasingly popular alternative to the discomfort of scientifically verifiable chemotherapy.

Ho and colleagues tested their technique in a rat model of cancer using three FDA - approved chemotherapy nanodrugs, Abraxane ®, Marqibo ® and Onivyde ®, and one experimental platinum - based anti-cancer nanodrug.

According to U.S. and European records, another one of the drugs approved based on research at Cetero's troubled Houston lab was a chemotherapy drug known as Temodar for Injection.

Chemotherapy use in adult MB is largely based on pediatric outcomes, and its effectiveness has been unclear.

Findings based on this new technology are likely to have a profound impact on improving the detection and diagnosis of diseased cells and in evaluating a patient's response to chemotherapy.

Patients were categorized into those who had a good response and those who had a poor response to chemotherapy, based on a recently approved chemotherapy response score that correlates with progression - free and overall survival.

This study of 37 patients (24 men and 13 women, ages 51 to 80) who have never been treated with chemotherapy found direct correlation of the amount of cfDNA with tumor metabolism (based on PET - derived parameters), but not with metabolic tumor volume.

As part of the project, announced last week by Kenneth Hagemann, director of the Pentagon's Defense Nuclear Agency, 24 soldiers from Brooks Air Force Base in Texas are taking prescription drugs — ondansetron hydrochloride and granisetron hydrochloride — that are given to cancer patients undergoing radiotherapy or chemotherapy.

It is the first time a therapy has improved progression - free survival over the current standard first line treatment with platinum - based doublet chemotherapy.»

Dr Fiona Blackhall, a senior lecturer in The University of Manchester's Institute of Cancer Sciences and a consultant based at The Christie NHS Foundation Trust — both part of the Manchester Cancer Research Centre — said: «In order to introduce precision medicine, where each cancer patient receives treatment designed to target the genetic makeup of their individual cancer, we need to compare how effective the new targeted treatment is compared to standard chemotherapy treatment.»

This makes the starter materials for synthesizing the complex far more economical than a number of industry - standard chemotherapy drugs based on platinum.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

Based on an analysis of existing evidence, published in an opinion article in the Nature Reviews Clinical Oncology journal on January 20, Dr. Narod argues that to achieve a cure, rather than simply delay progression or reoccurrence of the disease, women should be first treated with aggressive surgery to remove all clinically - detectable cancer cells, followed by targeted chemotherapy to the abdomen (intraperitoneal chemotherapy).

«Randomized Controlled Pilot Trial of Mindfulness - based Stress Reduction for Breast and Colorectal Cancer Survivors: Effects on Cancer - related Cognitive Impairment,» published online in advance of print in the Journal of Cancer Survivorship, is the first randomized clinical trial to evaluate the effects of mindfulness - based stress reduction, known as MBSR, on fatigued breast and colorectal cancer survivors, the majority of whom had been treated with chemotherapy.

Appearing in Lancet Oncology, long term results of EORTC trial 22921 with 10.4 years median follow - up show that 5 - FU (fluorouracil) based adjuvant chemotherapy after preoperative (chemo)- radiotherapy for patients with cT3 - resectable T4 M0 rectal cancer does not improve survival or disease - free survival.

Based on recent information on the mechanisms of chemotherapy, a team of researchers of the McGill University Health Centre (MUHC) developed a new clinical approach to increase the efficiency of treatment in glioblastomas that increased the median survival to 22 months — bringing much needed hope to those affected by this aggressive disease.

The company behind the test, Agendia, based in the Netherlands, estimates that it will spare 60,000 American women unnecessary chemotherapy each year.

«This paper reveals a metabolic frailty in cancer cells that is based on their own production of oxidizing agents that allows us to utilize existing redox active compounds, like vitamin C, to sensitize cancer cells to radiation and chemotherapy,» says co-author Garry Buettner, who was one of the first to propose that cancer cells might have a vulnerability to redox active compounds over 40 years ago.

A stem cell - based method created by University of California, Irvine scientists can selectively target and kill cancerous tissue while preventing some of the toxic side effects of chemotherapy by treating the disease in a more localized way.

«Based on this research, we are now conducting a first - in - human study combining the PARP inhibitor with radiation and chemotherapy in patients with locally advanced pancreatic cancer, with an ultimate goal of improving survival rates and treatment outcomes,» said Tuli.

In a study appearing in the May 3 issue of JAMA, Pascal Hammel, M.D., of Beaujon Hospital, Clichy, France and colleagues assessed whether chemoradiotherapy improves overall survival of patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine - based induction chemotherapy, and assessed the effect of erlotinib on survival.