Sentences with phrase «based chimeric»
Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).
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US - based pharmaceutical company Gilead Sciences entered the chimeric antigen receptor (CAR) T - cell therapy business through its acquisition of Kite Pharma, and Australian biopharma company CSL Behring acquired US - based Calimmune, a company that develops clinical - stage gene therapy solutions.
Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.
A transformative cancer therapy based on modified immune cells has lured doctors, companies, and patients alike, but many are hitting a frustrating roadblock: generating enough of these chimeric antigen receptor (CAR)- T cells to meet surging demand.
The proposed gene therapy is based on the success of small human trials of killer T - cells (Chimeric Antigen Receptor [CAR] T - cell therapy).
One recent advance in cell - based therapies is the dramatic progress of chimeric antigen receptor T (CAR - T) cell therapies in the treatment of certain blood cancers.
Attempts to test the intrinsic role of S1pr1 using BM chimeras were unsuccessful due to difficulties in achieving efficient reconstitution of IL7RαhiCcr6 + cells and our finding that many of the cells developing in the chimeric mice appeared activated based on CD69 expression (not shown).