Typical microarray -
based gene expression analyses compare gene expression in adjacent normal and cancerous tissues.
Not exact matches
Scientists from the Biogerontology Research Foundation (BGRF), a UK -
based charity founded to support aging research and address the challenges of a rapidly aging population, propose a new concept for signalome - wide
analysis of changes in intracellular pathways, called OncoFinder, which allows for accurate and robust cross-platform
analysis of
gene expression data.
Biomolecular model
based on the
gene expression data
analyses support the reduction of glucose molecules (blue gradient) and acid buildup (gold gradient) proposed to occur in the boundary layer around the cell.
Indeed, the team identified high variation in adjacent «normal» tissue samples, which are typically used as control samples for comparison in
analyses based on mean
gene expression.
Based on
analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in
gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.
In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular
basis in the brain by conducting prediction
analyses of the
gene expression data.
Topics for the scientific sessions are: Single cell genomics and
gene expression Genetic interactions RNAi and somatic cell genetics Protein - DNA interactions Cancer The meeting also highlights existing opportunities for academic and industrial researchers to access automated cell -
based and biochemical technologies
based at the Karolinska High Throughput Center; home to one of the most sophisticated, state - of - the - art, ultra-high performance liquid handling and
analysis platforms in Europe.
Thus, interactome hubs such as NR1 may exhibit low levels of change in individual
gene expression following hypoxia, but,
based on
analysis of interaction networks, are likely to play an important role in regulating the biologic response.
Inspired by the knowledge -
based analysis methods developed for
gene expression data
analysis, we implemented methods for examining functionally - related SNPs as a group.
Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used
analysis methods for determining
gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder
basis for determining changes in
gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»
In small cell lung cancer, starting from bioinformatics
analyses of large
gene expression datasets, we clustered subsets of co-expressed
gene modules, derived networks of transcription factors and simulated their dynamics using logic -
based mathematical modeling.
These webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico
gene function prediction through a series of integrative and complimentary systems analytical approaches, including (
expression -
based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation
analysis.
The webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico
gene function prediction through a series of integrative and complimentary systems analytical approaches, including (
expression -
based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation
analysis (Figure 1 - 2).
Because both IRF - 1 and the complex IRF - 9 / STAT2 could bind the RIG - G
gene, we therefore conducted a detailed functional
analysis on RIG - G promoter to precise the molecular
basis for RIG - G
expression.
The set of possible
analyses include: 1) comparison of cell populations for the identification of differentially expressed
genes; 2) dimensionality reduction for the identification of relevant coordinates; and 3) clustering of subpopulations on the
base of
gene expression profiles.
An approach
based on testicular
analysis of candidate
gene expression between IVC - and in vivo (control)- produced animals was performed.
Although many common
genes were expressed in the three tissues, cluster
analysis based on transcript levels revealed distinct
gene expression profiles of the d - 18 EET (Fig. 2C and SI Appendix, Fig.