Sentences with phrase «based gene level»

12:30 PM Tissue - specific imputed transcriptome based gene level association test using summary statistics.

Not exact matches

Women with high levels of FGF1 were less likely to respond to platinum - based drugs, but blocking the gene makes their cells lose their resistance (British Journal of Cancer, DOI: 10.1038 / bjc.2012.410).

Every gene was assigned a score, based on previous studies, where 0 indicated that the polymorphism of this gene did not create a muscular advantage for running a marathon, 1 meant a standard level and 2 indicated that the polymorphism of the gene conferred positive properties for bearing this effort through muscles.

At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment.

To achieve this level of insight will require a network ‐ based analysis of the associations among the individual genes, proteins, metabolites, intermediate phenotypes, and environmental factors that conspire to yield the pathophenotype.

This is in contrast to the well - characterized VRC01 - like family of CD4 - binding site antibodies identified in multiple HIV - positive donors, which share both a heavy chain V gene precursor and unusual features at a DNA sequence level which could allow sequencing - based identification of other similar antibodies in distinct patients [53].

This technology is based on differential expression of key gene transcript variants (isoform - level gene expression) and was originally tested on a vast collection of glioblastoma samples made available by the University of Pennsylvania.

Thus, interactome hubs such as NR1 may exhibit low levels of change in individual gene expression following hypoxia, but, based on analysis of interaction networks, are likely to play an important role in regulating the biologic response.

At the most basic level, viral vectors consist of a viral genome that has been adapted into a plasmid - based technology and modified for safety through the removal of many essential genes and the separation of the viral components.

Cyclin A2: Increased levels of cyclin A2 have been shown to increase the regenerative capacity of heart tissue, one of an array of proteins that might for the basis for regenerative gene therapies for heart disease, and thus also might be beneficial to undergo far in advance of old age so as to slow or postpone degeneration in the heart.

These targets were identified based on the presence of predicted regulator binding sites or experimental regulator binding in the target promoter, and / or changes in the target gene's transcript levels in regulator mutant strains.

Gene - level expression values were represented by fragments per kilobase exon per million reads mapped (FPKM) and a consensus FPKM was determined for each gene based on its representation across biological replicaGene - level expression values were represented by fragments per kilobase exon per million reads mapped (FPKM) and a consensus FPKM was determined for each gene based on its representation across biological replicagene based on its representation across biological replicates.

To evaluate the global human methylome in adipose tissue, we calculated the average level of methylation for all sites divided into groups based on either their location in relation to the nearest gene (Fig. 2A) or the location in relation to CpG islands (Fig. 2B)(24).

Supplementary Fig. 36a shows the performance of the model based on the TIN measure at the tissue level, while Supplementary Fig. 36b compares the predictions based on TIN with the predictions based on gene expression at the individual level.

Each gene detected by at least one of the MS - based studies is classified as «Evidence at protein level» and all remaining genes as «Not available».

The ML tree based on mitochondrial genes (Text S2) failed to recover the monophyly of several higher - level clades, including Primates and Haplorhini.

A reliability score is set manually for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA / gene characterization data from both HPA and the UniProtKB / Swiss - Prot database.

Rather, HAR2 functions as an enhancer, a DNA sequence that works to increase or decrease the level of a gene's expression.8 An enhancer can be located thousands of base pairs away from the gene it regulates.

Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used analysis methods for determining gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder basis for determining changes in gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»

In addition, for each gene, a protein evidence summary score is based on the maximum level of evidence in all three independent evidence scores (Evidence summary).

• Study achieves primary endpoints; DG031 shown to be well - tolerated and to significantly reduce levels of leukotriene B4 and myeloperoxidase • First ever clinical trial based upon the isolation of a disease gene in a common disease

A web - based tool in which users can upload their individual SNP data and obtain predicted expression levels for the set of predictable genes across the 14 different cell types.

A reliability score is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA / gene characterization data.

On the basis of 326,000 polymorphisms, we found low to moderate overall levels of differentiation between subspecies, and fewer than 200 genomic regions dispersed throughout the genome showing high differentiation consistent with a signature of reduced gene flow.

Moreover, in PrEn precursors, the Nanog low population can itself be split based on the expression of Oct4 or SSEA - 1 into a state expressing reasonably high level of PrEn genes (V+S −), and a less differentiated cell type exhibiting a PrEn bias, but with similar regenerative capacities to the Nanog high population (V+S +).

Genetic studies using samples along the distribution range of both subspecies and based on a few dozen nuclear markers have revealed loci of relatively high divergence (0.3 — 1.2 %) between subspecies embedded in a genome otherwise characterized by low levels of differentiation and high levels of bidirectional gene flow [21], [24]--[26], likely facilitated by high effective population sizes, high dispersal, and a relatively short generation time [21], [24]--[26].

This gene - level resolution yielded several insights into the genetic basis and architecture of reproductive isolation in rabbits.

• Study achieves primary endpoints; DG031 shown to be well - tolerated and to significantly reduce levels of leukotriene B4 and myeloperoxidase • First ever clinical trial based upon the isolation of a disease gene in a common disease Reykjavik, ICELAND, October 19,...

To annotate the genome, the team generated transcriptome sequence data — which can be used to measure gene expression based on RNA levels — in 12 different tissues types.

Although many common genes were expressed in the three tissues, cluster analysis based on transcript levels revealed distinct gene expression profiles of the d - 18 EET (Fig. 2C and SI Appendix, Fig.

Same exact genes, but those eating more plant - based diets had more favorable levels of this hormone, secreted by human fat cells, that helps control weight.

In addition, Infinity Gene has a killer auxiliary mode that creates a dynamic level based on a music selection from your iPod library.