Sentences with phrase «based gene silencing»

In this episode, Dr. Carlos Faraco speaks with Dr. Don Cleveland of the University of California San Diego regarding his work on drug - based gene silencing therapies.

Since RNA - based gene silencing drugs have been successful so far, why bother with the greater challenge of targeting the DNA of the huntingtin gene itself, especially if it means dealing with virus particles and big, fragile drugs made of protein?

Please recognise that the recent progress in the field of RNA - based gene silencing has involved original scientific inquiry from research groups around the world.»

Not exact matches

«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»

One of Beaudet's graduate students — Linyan Meng — was writing her dissertation on Angelman syndrome and was wrestling with this problem when a member of her dissertation committee, Dr. Thomas Cooper, professor of pathology & immunology at Baylor, said he was working with a Carlsbad, Calif. - based company called Isis Pharmaceuticals that had anti-sense oligonucleotides that could turn off the antisense transcript that silenced the paternal copy of the gene.

The third PDR approach and the one that we intend using not only for MSV resistance but also for other viruses such as MRDV, is based on something called RNA - mediated gene silencing.

We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47 - base 3» untranslated region motif is implicated in this process.

ONE - PARENT SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expressed.

After receiving a PhD in molecular genetics and gene silencing from Pierre and Marie Curie University Paris, I joined as a postdoc the laboratory of Frederic Rosa at Ecole Normale Superieure Paris to investigate the genetic basis of vertebrate development.