Sentences with phrase «based genome analysis»

Family - based genome analysis enabled us to narrow the candidate genes for both of these Mendelian disorders to only four.

Not exact matches

These genomic variations have been revealed by studies in the population and by analysis of the genomes of colon cancer patients that are available in data bases such as that of the 1000 Genomes Projecgenomes of colon cancer patients that are available in data bases such as that of the 1000 Genomes ProjecGenomes Project Data.

Analysis of the 1,042,519 — base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae.

New DNA - based LASSO molecule probe can bind target genome regions for functional cloning and analysis.

The bacterium Streptomyces chartreusis is an antibiotic - producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome.

As part of ENCODE, 32 institutions did computer analyses, biochemical tests, and sequencing studies on 147 cell types — six fairly extensively — to find out what each of the genome's 3 billion bases does.

According to the report on the effort, which was published in the December 11 issue of Science, analysis of the worm's genome revealed 19,099 protein - coding genes — about one every 5,000 DNA bases — and 800 or so genes that have other functions.

At the same meeting, Kerstin Lindblad - Toh of the MIT Broad Institute in Cambridge, Massachusetts, and her colleagues outlined the initial analysis of the 2.4 billion bases of the dog genome.

The conflicting analyses, however, were based on small snippets of the genome.

Now, both groups have published their analysis of the genomes, and their findings reveal the molecular basis behind these snakes» remarkable traits.

These include two flagship papers: one exploiting genomic - scale data to generate a highly supported avian order phylogeny that resolves many debates on the timing and topology of their radiation; the other a comparative genomic analysis exploring avian genome evolution and the genetic basis of complex traits.

DEEP ROOTS Analysis of the Mnemiopsis leidyi comb jelly's genome suggests it sits at the base of the tree of animal life.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Unlike the SNP - based analysis described above, single - sample genotype calling was performed with no particular ascertainment scheme, and we restricted our analysis to eight canid genomes with coverage ranging from 8 to 24 ×.

The initial version of CRI iAtlas is based on an analysis performed by The Cancer Genome Atlas (TCGA) Research Network on the TCGA data set comprising over 10,000 tumor samples and 33 tumor samples (Thorsson et al..

• Mouse whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic sofgenome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic sofGenome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic software.

This is because both our analysis and previous analyses relied heavily on the assumption of parsimonious genome evolution, where lineage - specific gain and loss patterns are based on the fewest possible evolutionary changes.

Proteomics (Fagerberg et al, «Analysis of the human tissue - specific expression by genome - wide integration of transcriptomics and antibody - based proteomics») with a focus in the article on the tissue - specific pattern in the human body.

Based at the Wellcome Trust Sanger Institute, Magnus works on the scientific analysis of high - throughput genome sequencing data for MalariaGEN, primarily on pathogen projects.

We present evidence for three ancient genome duplications during the evolution of gymnosperms, based on phylogenomic analyses of transcriptomes from 24 gymnosperms and 3 outgroups.

As a part of VIOLIN, we have developed Vaxign, the first web - based publically available vaccine target design tool based on bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.

Analysis of the human tissue - specific expression by genome - wide integration of transcriptomics and antibody - based proteomics.

A key program of VIOLIN is Vaxign, the first web - based publically available vaccine target design tool based on bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.

Since our analyses are often based on multiple genome alignments, we are also interested in improving whole genome alignment methods.

The same staff and facility also process deCODE's DNA - based reference laboratory tests for gauging individual risk of major public health challenges ranging from heart attack to breast cancer, as well as the company's pioneering deCODEme ™ scans, the world's first personal genome analysis and focused disease area scans.

The goal of this workshop is to empower faculty to integrate modern methods for genome analysis into their teaching, especially as course - based undergraduate research experiences (CUREs).

Pathway - based analysis of a melanoma genome - wide association study: analysis of genes related to tumour - immunosuppression.

The mean timetree date for Platyrrhini based on our analyses was 23.3 million years, which is slightly older than Hodgson et al.'s [59] date of 19.5 Ma that was obtained with complete mitochondrial genome sequences and Thorne and Kishino's [84] multidivtime program.

These advances are based on the accumulation of genome sequencing data on thousands of individuals, which have revealed common patterns of genetic variation in Europe and have enabled detailed statistical analyses of genetic factors that determine resistance and susceptibility to specific diseases.

PLINK: a tool set for whole - genome association and population - based linkage analyses.

«Recent advances in genome sequencing and analysis are making it possible to systematically unravel the genetic basis of disease,» said Eric Lander, director and president of the Broad Institute and a principal investigator of the CCDG.

As part of her current work under the Fungal Genome Initiative at the Broad, Cuomo leads analysis of a wide diversity of animal and plant pathogens, with the goal of better understanding the genetic basis of pathogenicity.

Shmulevich directs a Genome Data Analysis Center at ISB as part of The Cancer Genome Atlas project, which is using genome analyses to accelerate understanding of the molecular basis of cGenome Data Analysis Center at ISB as part of The Cancer Genome Atlas project, which is using genome analyses to accelerate understanding of the molecular basis of cGenome Atlas project, which is using genome analyses to accelerate understanding of the molecular basis of cgenome analyses to accelerate understanding of the molecular basis of cancer.

Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than replication - based analysis for two - stage genome - wide association studies.

Base recalibration was performed using the Genome Analysis ToolKit (GATK)[16] v1.3.

Genome - wide CRISPR - based knockout (CRISPR - KO) screening is an emerging technique which enables systematic genetic analysis of a cellular or molecular phenotype in question.

Recent notable enhancements include user - directed submission of data, such as micropublication; genomic data curation and presentation, including additional genomes and JBrowse, respectively; new query tools, such as SimpleMine, Gene Enrichment Analysis; new data displays, such as the Person Lineage browser and the Summary of Ontology - based Annotations.

12/2: 45 Improved identification of the genetic basis of disease by integrated analysis of RNA - seq together with whole - genome and exome - based sequencing data.

SNP - based phylogenetic analysis was undertaken to understand this result: the PCR - positive ST109 genomes were almost identical to ST47 genomes, with the exception of a recombined region probably acquired by ST47 from a ST62 -LRB-- like) strain.

TCGA, launched in 2005, is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large - scale genome sequencing.

The increasing number of drugs targeting specific proteins implicated in tumourigenesis and the commercial promotion of relatively affordable genome - wide analyses has led to an increasing expectation among patients with cancer that they can now receive effective personalised treatment based on the often complex genomic signature of their tumour.

Reference genome regions composed of undefined bases (Ns) as well as chr Y were not considered in our analyses.

7/3: 30 Cross-cancer genome - wide pleiotropy analysis based on GAME - ON and GECCO across five common cancers: Lung, ovary, breast, prostate, and colon cancer.

The Department of Microbiology of the Yonsei University College of Medicine, is investigating on identification and functional study of virulence determinants in Mycobacterium tuberculosis by comparative genome - based analysis.

Here we describe genome - engineering based evaluation of RNA regulatory element activity (GenERA), a clustered regularly interspaced short palindromic repeats (CRISPR)- Cas9 platform for in situ high - content functional analysis of RREs.

He directs a Genome Data Analysis Center as part of The Cancer Genome Atlas (TCGA) project, a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large - scale genome sequeGenome Data Analysis Center as part of The Cancer Genome Atlas (TCGA) project, a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large - scale genome seqAnalysis Center as part of The Cancer Genome Atlas (TCGA) project, a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large - scale genome sequeGenome Atlas (TCGA) project, a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large - scale genome sequegenome analysis technologies, including large - scale genome seqanalysis technologies, including large - scale genome sequegenome sequencing.

On a safari through the genome — genes offer new insights into the distribution of giraffes (17/11/2014) A team from the LOEWE Biodiversity and Climate Research Center (BiK - F), in conjunction with the Giraffe Conservation Foundation, has conducted a detailed analysis of these animals» spatial distribution based on their genetic profile....

LDA analysis for RNA transcription of selected genes located throughout the B. burgdorferi cN40 genome in flaB DNA - positive heart base (HB) and tibiotarsal (Tt) tissue samples from infected mice at 12 months following treatment with saline or antibiotic.

All of this work is based on our successful published efforts to both build tools and analyze sequence analysis from the canine genome.

A group of researchers led by Washington University in St. Louis, MO, recently completed the first high - quality feline genome analysis (based on DNA from an Abyssinian cat named Cinnamon).