Sentences with phrase «based on animal models»

Our current armamentarium of chemo drugs and radiation is based on animal models.

Much of what is known about the course of the disease before symptoms appear is based on animal models.

«My former advisor at Oxford has a variety of interests, all very much based on animal models of how the brain is organized for skilled performance.

Based on animal models, including a primate model, it is hypothesized that the cells remain unharmed in the digestive tract of the infant then enter the bloodstream, migrate to different organs, and there provide active immunity.54

Not exact matches

Based on their findings, they urge that «mosquito saliva and enhancing antibodies thus need to be considered when developing vaccines and drugs against dengue,» and specifically suggest that «animal models of dengue and pre-clinical validation of dengue vaccine candidates should be evaluated in the combined presence of mosquito saliva and enhancing antibodies.»

New experimental models based on three - dimensional reconstructions of human skin are helping to reduce chemical testing on live animals, but can not yet replace animals altogether

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

One 2014 study based on modeling animal movement found that increasing vehicle density on existing roads, rather than adding more roads with lower density, resulted in fewer wildlife fatalities.

Importantly, the development of a new animal model for Dravet syndrome based on reduced CHD2 expression might help to find effective treatments that could improve the lives of thousands of people suffering from Dravet syndrome and perhaps other genetic epilepsies.»

The study is one of the first to test if the «landscape of fear» model, a scientific theory that has been used to explain how animals move and interact with the environment based on their fear of being attacked by their predators, is applicable to large open marine systems involving wide - ranging species, like sharks and turtles.

«Since it's quite difficult to track microbial exposure on a daily basis, especially with humans — who move around a lot — we're exploring new animal models to see if we can ask the same questions we would about humans and get answers in more rigorous, controlled ways,» Gilbert said.

The researchers, who evaluated the BSCB in test animals at seven and 30 days after stroke modeling, found that ischemic stroke damaged the gray and white matter in the cervical spinal cord on both sides of the spinal column, based on analysis of electron microscope images.

By using new techniques based on computerised X-ray micro-tomography (CT scan) and digital three - dimensional modelling, Benoit found that the maxillary canal of therapsids, a bony tube in the snout of the animal that houses the trigeminal nerve, is shorter in therapsids than in reptiles.

In all three animal models, the researchers utilized a recombinant adeno - associated viral (rAAV) vector delivery system based on a subtype known as AAV - DJ / 8.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

«Non-linear» animal reactions He and his colleagues based their analysis on nearly 500 million temperature records collected at 3,000 weather stations between 1961 and 2009, feeding that information into models that allowed them to estimate how climate shifts affected the metabolism of cold - blooded insects, lizards and amphibians around the world.

A new estimate, based on mathematical modeling and a major bug - counting effort in New Guinea, puts the number of arthropod species in the tropics — which account for most of the animal species in the world — at about 3.7 million, way below the 30 million once suggested.

«Because plants make their decisions based on physiological processes and are not distracted from the best course of action by subjective thought, they could even be better models than animals and people,» says Bernhard Schmid from the University of Zurich.

To this end, the researchers selected an approach based on machine learning that is often used in nature and wildlife conservation to develop models for the distribution of various species of plants and animals.

A researcher describes how his mathematical model based on heat diffusion reveals the critical role played by large animals in dispersing nutrients

But based on studies in animal models of pancreatic cancer, U-M researchers and colleagues theorized that dissemination happens before we tumors can be detected.

According to the model, an animal that bases its decisions only on its current energy reserves can survive almost as long as one that uses its brain to calculate the best thing to do.

IDMIT will contribute 1) To the development and validation of assays based on flow cytometry and mass cytometry for the evaluation of immune responses in humans and animal models; these tools will be particularly relevant for the identification of signatures of vaccine efficacy; 2) To the animal model platform, in particularly by providing access to NHP models and to new technologies for in vivo imaging infections and host responses; 3) To networking activities, in particular by organising a workshop on in vivo imaging.

Our work focused on Drosophilia, one of the most powerful animal models for studying the cellular and molecular basis of sleep - wake rhythms.

Services currently offered: We offer contract research based on the well - characterised animal models and infrastructure described above, which has been used in several EU projects.

Based on their expertise in immunology and pathology and the available infection models, vaccines against most relevant viral and bacterial animal infections can be tested.

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In addition to a detailed study of the mudskipper and development of a robot model that used the animal's locomotion techniques, the study also examined flow and drag conditions in representative granular materials and applied a mathematical model incorporating new physics based on the drag research.

Mu and McCarl (2011) predict that pasture use will increase relative to cropland based on modeling a combination of forage and animal response factors.

The research team now concentrates on using CBS - based therapy in other animal infection models, e.g. urinary tract infection (UTI), hoping to offer a more extensive approach to combat with antibiotic resistant superbugs.

Burmeister et al. employed deep partial thickness burns on the dorsum of Yorkshire pigs as a model system to assess the efficacy of their new ASC - based approach, as this clinically - relevant large animal represents the best surrogate for human skin [5].

On this basis, a ketogenic diet has been proposed as a collateral therapeutic approach in this disease.95 Studies by Zhao et al. 96 revealed both histological and functional improvements in an animal model of amyotrophic lateral sclerosis when a ketogenic diet was given compared with when given a control diet.

On the basis of these consistent and robust data from animal models, a recent report in European dieters found a significant association between the timing of lunch and weight - loss effectiveness, with earlier lunch times linked to greater success (45).

Since Animal Crossing: Pocket Camp is a smartphone game, with micro-transactions as business model, it's going to get various events and content updates on a regular basis.

Much of medical science derived for human treatment programs is based on earlier research involving animal models.

Nevertheless, both Patronek and Frost describe — based on some of the earliest research on the subject — some common characteristics of, and explanatory models for animal hoarding.

ALDF has drafted a Model Law for a Private Right of Action, based on North Carolina's unique provision that, if passed in other states, would greatly reduce the burden on local prosecutors and allow concerned citizens and animal protection groups to stop the tragedy of hoarding in their own communities throughout the country.

Prediction models based on summer time measurements show increasing acidity by 2070 that would have a major impact on animals with shells and animals at the bottom of the food chain that would then work its way up to affecting the large animals that depend on them for food.

Animal models also suggest that early adversity has a negative impact on the development of prefrontal cortex - based cognitive functions.