Sentences with phrase «based on antibodies»

- A large proportion of new targeted cancer therapies are based on antibodies.

Vanapalli and his collaborators, including Wei Li, an assistant professor in the Department of Chemical Engineering, propose a new type of testing, one not based on antibodies and without markers, but holography.

The Wuhan lab will give his group a chance to study how such viruses cause disease, and to develop treatments based on antibodies and small molecules, he says.

These libraries consist of sequences based on antibodies found in hundreds of people; Van Blarcom uses his bioinformatics knowledge to curate this data.

Other immune therapies based on antibodies have also produced impressive outcomes in recent years.

Roughly a decade ago Pfizer (PFE) developed a drug based on an antibody that it, too, licensed from Medarex — but gave up on it, says Allison, when the drug didn't immediately shrink tumors.

Olink's Proximity Extension Assay (PEA) detection technology is based on antibody probes linked to DNA tags.

Increase survival from the time of listing by more than 1 year (adjusted for quality of life) as compared to waiting for transplantation based on antibody status.

The engineered protein has two ends: one activates T cells by binding to a surface molecule called the CD3 receptor, and the other — based on an antibody called VRC07 — powerfully binds to more than 90 percent of HIV strains.

While there are a number of portable tests for cocaine commercially available, these are mainly based on antibody reagents, which can not offer quantitative data and — since the cocaine antibody can bind to something that is not cocaine — can give false positive results.

«We think we probably will be able to make a call based on the antibody levels in this individual,» says Plummer.

Based on this antibody's actions, scientists have developed a preliminary vaccine that shows promise in mice.

Interestingly we observed approximately a 2-fold change in Nanog transcript levels between the two populations, and thus while the V+S + cells appear Nanog negative based on antibody staining, they still express some Nanog transcript.

For rabies, frequency is based on the antibody tests and the prevalence of the disease in your area.

The nomograph was based on the antibody titers of the mothers.

The AAHA further states that hepatitis and parvovirus vaccines have been proven to protect for a minimum of 7 years by challenge and up to 9 and 10 years based on antibody count.

The American Animal Hospital Association only makes this report available to veterinarians, not private citizens, and Maine's pet owners are unaware that the AAHA Guidelines state on Page 18: «We now know that booster injections are of no value in dogs already immune, and immunity from distemper infection and vaccination lasts for a minimum of 7 years based on challenge studies and up to 15 years (a lifetime) based on antibody titer.»

After that subsequent vaccination boosters are given every 1 to 3 years or based on antibody levels depending on the policy of the supervising animal hospital.

We made this assumption based on antibody levels to toxoplasma in the pet.

Not exact matches

• Arsanis, a Waltham, Mass. - based clinical stage biopharmaceutical company focused on monoclonal antibodies, raised $ 40 million in an offering of 4 million shares at $ 10 a piece, below its $ 15 to $ 17 range.

In its latest study published in a special section of the Journal of AOAC International focusing on food allergens and gluten, GIG said obtaining representative test samples for antibody - based testing (traditional way for testing gluten) is challenging when analyzing whole grains for gluten.

Children with negative or low antibody levels and even moderate levels may not actually be allergic to those foods, so those test results must be interpreted based on the symptoms the child has when he eats those foods.

Breast milk is considered the perfect blend of water and fat and protein and carbohydrates, laced with the antibodies of the mother, in a recipe that mysteriously alters based on the needs of the baby.

Women who've just given birth are ordered not to be so «selfish», yet isn't selfish to base serious parenting decisions on something other than the antibodies found in a particular liquid, a liquid for which there is another, perfectly acceptable if not - so - antibody - tastic substitute.

Macrogenics, a biopharmaceutical company, is focused on discovering and developing innovative antibody - based therapeutics for the treatment of cancer, as well as various autoimmune disorders and infectious diseases.

In the spring, the U.S. Food and Drug Administration approved an antibody that is the first cancer therapy based on a tumor genetic biomarker instead of a location in the body.

Based on their findings, they urge that «mosquito saliva and enhancing antibodies thus need to be considered when developing vaccines and drugs against dengue,» and specifically suggest that «animal models of dengue and pre-clinical validation of dengue vaccine candidates should be evaluated in the combined presence of mosquito saliva and enhancing antibodies.»

Ethical concerns After two infected Americans were treated with a cocktail of antibodies made by Mapp Biopharmaceutical of San Diego, California, three UK - based international health experts called on 5 August for such drugs to be made available to Africans.

Influenza viruses belong to the Orthomyxoviridae family and are divided into A, B and C types based on their antigen (antibody - producing) protein type.

The only FDA approved Lyme disease tests, based on technology developed more than two decades ago, rely on detecting antibodies that the body's immune system makes in response to the disease.

«Broadly neutralizing antibodies have some unusual features,» says Dr Penny Moore, from Wits University and one of the lead South African scientists on the study based at the NICD.

Approaches based on these five strategies have been used for streamlined, enhanced validation of more than 10,000 antibodies from more than 30 providers, targeting over 7,000 human proteins as part of the Human Protein Atlas program.

Five alternative strategies for enhanced validation of antibodies will be described based on genetic validation, recombinant expression, independent antibodies, orthogonal validation, and capture mass spectrometry validation.

In the past, scientists have tried to determine therapeutic effectiveness by separating patients into groups based on their clinical parameters such as what antibodies they are producing against themselves, how swollen their joints are and medications they are taking.

For starters, producing antibody - based antivenoms is time consuming and expensive, making it difficult for drug companies to make money on their sale, says Ken Shea, a chemist at the University of California, Irvine, who led the new work.

«Our analysis shows that denial of listing for transplant, solely on the basis of having too many antibodies, is unwarranted,» Feingold said.

Unlike antibodies, the T cells recognize flu viruses based on shared internal proteins.

CIEP and similar immunological methods «are based on detecting proteins by using antibodies that would recognize the protein by shape.

In its first test in humans, reported online October 4 in the New England Journal of Medicine, one vaccine based on DNA from the virus elicited an immune response, with 100 percent of participants developing antibodies after a three - dose regimen.

On the basis of isotope incorporation experiments and kinetic data, we propose that antibodies use H2O as an electron source, facilitating its addition to 1O2 * to form H2O3 as the first intermediate in a reaction cascade that eventually leads to H2O2.

Their method translates the presence of each antibody into a unique piece of DNA whereby the DNA computer can decide on the basis of the presence of one or more antibodies whether drug delivery, for example, is necessary.

The microchip relies on a fluorescence - based method for detecting the antibodies.

They found antibodies in about half of 500 people who had handled infected poultry; based on the total number of poultry workers at risk, the team concludes that at least 1000 people must have become infected, most of them without any symptoms.

Injections of antibody molecules that block CD47 from interacting with SIRPA are already being tried in the clinic based on observations of some reduction in the sizes of tumors in mouse models.

So the scientists constructed a protein fragment based on a DNA sequence made up of bases complementary to those of the PrP gene, and then developed an antibody to the protein fragment.

A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific protein.

The Pasteur team says the finding could lead to the development of vaccines based on CD26 inhibitors or an antibody targeting either the V3 loop or CD26.

Kobinger said he had no idea whether the antibodies had any effect on viral load in these patients, as they were given the experimental ZMapp on a «compassionate use» basis.

Through a collaboration of two transplant centers in France and the United States, Carmen Lefaucheur, MD, PhD (Saint - Louis Hospital, in Paris) and his colleagues designed a study to determine the greatest risk for losing a transplanted organ based on the characteristics and function of donor - specific HLA antibodies.

The high costs associated with monoclonal antibody - based therapies puts a significant strain on the health - care economy, which may limit accessibility for patients.