Sentences with phrase «based on biomarker»

These scenarios are (1) to (4) based on the biomarker records from Core PS2757 - 8 (Fig. 2c).

14255: STAT3 Signaling During Chemo - Radiation for Squamous Cell Carcinoma of the Head and Neck 14340: A Phase II, Randomized, Open - Label, Multi-Center, Global Study of MEDI4736 Monotherapy, Tremelimumab Monotherapy, and MEDI4736 in Combination with Tremelimumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) 14258: Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

The legislation authorized the U.S. Food and Drug Administration to approve treatments based on biomarker data alone, and created a formal Biomarker Qualification Program.

October 1, 2015 University of Chicago researchers awarded $ 3.5 million as part of national consortium to transform diagnosis and treatment of psychotic disorders The National Institute of Mental Health (NIMH) has awarded researchers from the University of Chicago $ 3.5 million as part of the second phase of the Bipolar - Schizophrenia Network on Intermediate Phenotypes (B - SNIP2)-- a multi-university consortium that aims to establish a new system of diagnosis for psychotic diseases based on biomarkers, and guide the development of novel therapies.

This modified PIP25 approach is far less dependent on the balance factor c and based on biomarkers from the same group of compounds (i.e., HBIs) with more similar diagenetic sensitivity.

Not exact matches

In the spring, the U.S. Food and Drug Administration approved an antibody that is the first cancer therapy based on a tumor genetic biomarker instead of a location in the body.

«This gives us an underlying candidate biomarker panel that provides information on the subsequent clinical outcome or therapeutic efficacy, which can be validated to yield a final panel, then translated into say, an ELISA - based kit or some other immunodiagnostic format in the clinical setting,» says Dorfman.

The UMD and UMB team, led by research associate Eunkyoung Kim, used a discovery - driven approach based on the assumptions that chemical biomarkers relating to oxidative stress could be found in blood, and that they could be measured by common electrochemical instruments.

For the study, the Johns Hopkins team set out to lower the rate at which doctors order cardiac biomarker testing for the diagnosis of acute coronary syndrome by basing the desired rate on scientific evidence.

To speed up progress in biomarker - based research, international experts have defined five sequential phases on the road to new diagnosis and therapy options:

Killary said the team is working to use the biomarkers in MD Anderson's high - risk clinic, established through MD Anderson's Pancreatic Cancer Moon Shot ™, part of the institution's Moon Shots Program ™ to accelerate the development of life - saving advances based on scientific discovery.

According to lead author Mr James Oliver of the Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, UK, «in current clinical practice, RA drugs are administered on a trial and error basis; there are no clinical biomarkers of response to guide treatment decisions.

They are investigating indoor emissions in other areas of Tibet and plan to link these measurements to a biomarker study based on blood samples of people living in the households.

There are ongoing studies which focus on the discovery of molecular biomarkers of the VSV - ZEBOV vaccine in healthy individuals using omics - based technologies in combination with a systems biology approach,» says Ali Harandi.

«The results can also provide information to discover biomarkers for other vaccines based on living vectors.

Since the biomarker groups they investigated are based on algae — i.e., on plants that require light for photosynthesis — the absence of both groups is an important indicator of a very thick and largely contiguous ice cover.

The chemical biomarker can be detected noninvasively using technology based on magnetic resonance imaging.

Keytruda is the first approved drug that targets tumors with specific biomarkers, rather than based solely on their tissue origin (i.e. breast, lung, or colon).

Abnormal levels of the proteins may be useful biomarkers that could help us study early treatments to limit or reverse the damage to brain cells and even prevent the development of the full - blown disease,» said study author Edward Goetzl, MD, a Professor of Medicine with the University of California, San Francisco, a researcher at the National Institute on Aging, and a scientist of NanoSomiX, Inc., a California - based biotechnology company that provided a grant for method development for the study.

«Future sorting techniques based on cell stiffness and existing biomarkers may enable the enrichment of limbal stem cells, thus facilitating clinical success for patients with naturally low limbal stem cell percentages.»

It is a system for grouping biomarkers and classifying research participants on the basis of biomarker profiles.

In order to use these DM1 - specific biomarkers to develop new therapeutic treatments, we successfully developed technical assessments of miniaturization to realize high content screenings based on detection of the nuclear aggregation of the mutant mRNA.

Dr. Andrew Huberman: A biomarker can mean many different things, and when we set out to find a biomarker, we discussed whether or not this was going to be some way of imaging into the eye and seeing whether or not the retina was sick, whether or not it was going to be based on a blood draw, or some other measure.

Not all elderly people with Alzheimer's - like behaviors will be diagnosed with Alzheimer's disease as researchers propose a way of defining the disease based solely on biomarkers.

Other areas of research include designing novel therapies based on molecular pathways and identifying predictive biomarkers in patients to design personalized, targeted therapies.

Possible effects on other biomarkers and functional scales — including smartphone - based motion sensor data, the level of tau protein in the CSF (which they can measure), and the markers of dopamine metabolism in the brain (although you wouldn't necessarily expect an effect on that)-- are still under analysis.

Advances in the understanding of the biological bases of aging enable better assessment of acute effects of salutary interventions on biomarkers of aging.

Based on progress among the various laboratories and their collaborators, the CFC research team has narrowed their focus on three potential biomarkers.

Cellecta Inc., a functional genomics solutions provider, focuses primarily on developing and implementing flexible and scalable broad - based screening and analysis approaches for drug target and biomarker discovery.

Based on their success to date in models of glaucoma, the researchers are making significant steps toward moving into human testing and validation of a biomarker for clinical use.

His recent research has focused on the design and implementation of innovative algorithms to enable proteogenomic data analysis, pattern - based discovery of proteomic biomarker candidates, evaluation of data quality, assessment of variability and reproducibility in mass spectrometry based assays, and data visualization.

The medical research focuses on investigating the molecular basis of complex human diseases, and seeks to find biomarkers that can help diagnose diseases and monitor their progress.

In these cases, treatment decision is based on an analysis of biomarkers of response and resistance to cytotoxic drugs.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Our recent demonstration of high levels of classification accuracy based on examination of specific intrinsic large - scale networks in 7 — 12 year - old children highlights the utility of using data from narrower developmental windows to identify potential biomarkers for the disorder (Uddin et al., 2013).

Researchers revealed whole genome doubling as a milestone in disease progression and discovered a potential biomarker that is based on DNA methylation that may inform ACC drug therapies.

This article discusses the practical requirements and challenges of developing such new precision medicine strategies, based on leveraging complex genomic profiles, as discussed at the Innovation and Biomarkers in Cancer Drug Development meeting (8th - 9th September 2016, Brussels, Belgium).

• New human - specific biomarker identification and new drug discovery is possible using Organ - Chips, based on new insights into biological pathways of disease and immune system interaction.

The power of our biomarker panel to provide accurate risk prediction will continue to improve as we include additional biomarkers and build novel risk scores based on large population cohorts.

The team will continue to develop and test an imaging - based biomarker that can be used in a clinical setting to enable us to understand the molecular changes to the ganglion cells, so we can detect the disease very early on.

For the first time, NIA - AA proposal bases diagnosis in living people solely on biomarkers for plaques and tangles.

Advanced biomarker tests are uniquely prescribed based on patient symptoms, and run the gamut from evaluating inflammation, food allergies and hormone function to microbiome analysis and genetic screening.

You'll also receive a tailored recommendation based on your individual biomarkers, you'll have an audio recording of your phone session, and all of your written recommendations will be accessible and trackable in your WellnessFX.com profile or via mobile.

Supplement recommendations are based on addressing the biomarkers you have identified in testing.

To receive recommendations based on your unique biomarkers, consult your PCP or book a consultation with any of our nutritionists, registered dietitians or physicians.]

So this is based on epidemiological data, where we have taken large amounts of people, compared BMI, and healthy biomarkers to body fat percentages.

Based on my own experience with intermittent fasting, I believe it's one of the most powerful ways to shift your body into fat burning mode and improve a wide variety of biomarkers for disease.

I assess clients on an individual basis looking as dietary intake, biomarkers including a complete thyroid panel with RT3 and assess other nutrients related to thyroid function using Spectracell (that are easier to test than iodine).

We have all the research that has been done on couples looking for biomarkers that can determine compatibility and why certain couples do better than others, and so we launched [Instant Chemistry] based on that, and started working with premium matchmakers, giving out kits.

Our approach to achieving this goal focuses on three objectives: (1) to develop a reliable, predictive panel of biomarkers (including both biological and bio-behavioral measures) that can identify children, youth, and parents showing evidence of toxic stress, and that can be collected in pediatric primary care settings; (2) to conduct basic, animal and human research on critical periods in development and individual differences in stress susceptibility, thereby informing the timing and design of a suite of new interventions that address the roots of stress - related diseases early in the life cycle; and (3) to build a strong, community - based infrastructure through which scientists, practitioners, parents, and community leaders can apply new scientific insights and innovative measures to the development of more effective interventions in the first three postnatal years.