Sentences with phrase «based on the cell lines»

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

Many scientific journals require researchers who report results based on cell line experiments to use DNA profiling to establish the identity of the used cells.

Although the UCLA findings are preliminary, based on cell lines, and more suggestive than bulletproof at this stage, the Reuters headline «Cancer Cells Slurp Up Fructose» is fair warning to any of us addicted to fruit and fruit juices.

Not exact matches

Research based on such false cell lines would undermine the understanding of different cancers and possible treatments, and clutter the scientific literature with bogus conclusions.

If the president's philosophy — to restrict federal funding to research on cell lines created prior to August 9, 2001 — lacks a principled moral basis that amplifies the view that the governmental obstacles imposed on stem cell research, and the delays they have caused, themselves represent an ethical problem.

In addition, the bank «will actively recruit» the holders of existing hES cell lines around the world to deposit their cells, Radda says, and will work out intellectual property agreements with cell donors on a case - by - case basis.

Until the present study, demographic inference was based on only three Aboriginal Australian genomes; one was derived from a tuft of hair (taken from a deceased individual), and the other two from cell lines whose provenance is somewhat hazy.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.

The case for the all - conquering Africans is based mainly on studies of the Y chromosome and the mitochondrion, an energy - generating structure within the cell that has its own small genome and passes down the female line.

The potential influence of founder cells is profound for regenerative medicine and other medical applications, since they suggest that the cell line should be selected based on the desired cell type.

Roein - Peikar also noted that their experiments are mainly based on Chinese Ovary Hamster cells, a cell line derived from the ovary of the Chinese hamster, often used in biological and medical research.

With so much work needed in studying the nature of stem cells and using them to study disease processes, therapies based on ES cells seem very far down the line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.

Thus, our selection strategies, which were based on targeting endothelial populations that expressed both of these inducible glycoproteins, suggest that the endothelial cell lines generated in this study are most likely from this microcirculatory region.

\ n \ nIn other words this is a political attempt, based on a technicality, to advance science in the field by getting the US Administration to greatly expand the number of human ES - cell lines that can be used under federal funding.

The next step based on these novel head and neck cancer discoveries, the scientists agree, is to tease out how the genes function in normal cells, whether they form the lining of the larynx, pharynx, or another anatomical site affected by head and neck cancer.

In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.»

In MMEJ pathway, we achieve efficient gene disruption in human cell lines and animals by developing a computer program that assists the choice of nuclease target sites based on microhomology prediction.

The bottom line, says Daley, is that research on both types of stem cells must continue, because it's too early to predict where the safest and most effective cell - based therapies will come from.

Based on mRNA expression data, two suitable cell lines from the cell line panel are selected for the immunofluorescent analysis of each protein.

The selection was furthermore based on morphological characteristics, widespread use and multitude of publications using these cell lines.

For a total number of 131 cell line samples and 172 tissue samples, mRNA sequencing was performed on Illumina HiSeq2000 and 2500 machines (Illumina, San Diego, CA, USA) using the standard Illumina RNA - seq protocol with a read length of 2x100 bases.

Glial cell line - derived neurotrophic factor (GDNF) was selected based on clear evidence that it increases neuronal sprouting, prevents cell death [20], [21] and has neuroprotective effects in the brain [11], [22]--[24], spinal cord [12] and retina [25]--[30], and because receptors for GDNF are expressed within mature retina [26], [31]--[34].

Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.

We use an ES cell line in which low levels of Hex transcript are visualized based on the expression of the enhanced YFP, Venus coupled to a unique translational amplifier.

On the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude micOn the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude micon the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.

That bill, based on one from Rep. Diana DeGette, D - Colo., would have allowed federal dollars to flow toward research on stem cell lines using embryos left over from in vitro fertilization, slated for disposal and donated by the parents.

Other scalable systems include cell lines based on the Henrietta Lacks tumor (HeLa) and baby hamster kidney (BHK - 21) cells for adenovirus serotype 5 (Ad5) and herpes simplex virus 1 (HSV - 1) production (4, 40, 41).

Based on the resource of more than 47,000 antibodies and a panel of > 20 different human cell lines, this facility has a unique position to investigate subcellular spatial proteomics for human and rodent biology.

Based on this analysis, it was mistakenly deduced that XMRV could not have originated from LNCaP or another cell line in the laboratory.

Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.

One study examined the cytotoxic effects of different types of clove extract on breast cancer cell lines, including water - based, alcohol - based and essential oil extracts.

Year 6 Science Assessments and Tracking Objectives covered: Describe how living things are classified into broad groups according to common observable characteristics and based on similarities and differences, including micro-organisms, plants and animals Give reasons for classifying plants and animals based on specific characteristics Identify and name the main parts of the human circulatory system, and describe the functions of the heart, blood vessels and blood Recognise the impact of diet, exercise, drugs and lifestyle on the way their bodies function Describe the ways in which nutrients and water are transported within animals, including humans Recognise that living things have changed over time and that fossils provide information about living things that inhabited the Earth millions of years ago Recognise that living things produce offspring of the same kind, but normally offspring vary and are not identical to their parents Identify how animals and plants are adapted to suit their environment in different ways and that adaptation may lead to evolution Recognise that light appears to travel in straight lines Use the idea that light travels in straight lines to explain that objects are seen because they give out or reflect light into the eye Explain that we see things because light travels from light sources to our eyes or from light sources to objects and then to our eyes Use the idea that light travels in straight lines to explain why shadows have the same shape as the objects that cast them Associate the brightness of a lamp or the volume of a buzzer with the number and voltage of cells used in the circuit Compare and give reasons for variations in how components function, including the brightness of bulbs, the loudness of buzzers and the on / off position of switches Use recognised symbols when representing a simple circuit in a diagram

The world itself is fascinating too — it really is a fantasy based on reality, and I loved seeing modern technology like cell - phones, power - lines and cars appear alongside fantastical weapons and gigantic summoned wizards.

Yes, there are places in the United States where the sun is likely to shine on an un-obscured basis far more often than in other places, and transmission via HVDC lines (rather than AC) has materially less loss over long distances (and is convenient for solar since a solar cell generates DC power in the first place; as such it requires only one conversion, to AC at the receiving end, if HVDC transmission is used.)