Sentences with phrase «based on their chromatin»

Not exact matches

The 50 - year partnership of Donald and Ada Olins is based on good communication and a shared passion for chromatin structure.

Currently, enhancers can be identified through chromatin - based assays, such as ChIP - seq, which predict enhancer elements indirectly based on the enhancer's association with specific epigenomic marks, such as transcription factors or molecular tags on DNA - associated histone proteins.

The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of DNA - based motors using a combination of biochemical, biophysical and structural techniques.

To this end, we are developing a new multi-scale live imaging approach to characterize nuclear organization dynamics at the single cell level based on the simultaneous characterization of both the local dynamics of RNA polymerases and transcription factors and the large scale behavior of chromatin.

Xiaowei Zhuang, at Harvard University, and colleagues used super resolution microscopy to follow how chromatin packing changed based on its epigenetic modifications.

To study it, ENCODE utilized two approaches based on chromosome confirmation capture (3C), in which physically interacting regions are cross-linked by formaldehyde, and isolated from non-interacting chromatin with restriction enzymes.

Therapies that could be based on that insight are still in very early stages, he says — it's not easy to manipulate processes that have so many downstream consequences — but finding ways to address problems with chromatin might eventually help to extend human lives.