Sentences with phrase «based vaccine»

These results suggest that tumor antigen loaded CD40 - B may serve as a practical alternative to DC in cell - based vaccine strategies for both dogs and humans with cancer.

In this study, we clinically tested a therapeutic platform that we have previously described in preclinical studies [12] in which B cells from NHL dogs are expanded in vitro using CD40L transfected K562 cells (KtCD40L) and then loaded with autologous tumor RNA to generate a cell - based vaccine.

Cell - based vaccine strategies that stimulate anti-tumor immunity have shown promise in the treatment of many different cancer types including non-Hodgkin's lymphoma (NHL) in humans.

Find out more about current vaccinations, and learn which vaccinations would be best for each dog, with the Lifestyle - based Vaccine Calculator.

Lifestyle - Based Vaccine Calculator helps determine the specific vaccine needs of individual dogs.

Recently, fibrosarcomas have been removed from areas of the body typically used for vaccination and, to the surprise of the veterinary profession, particles of aluminum based vaccine ingredients (called «adjuvants») were discovered within the tumor.

The DNA - based vaccine contains genetic pieces of the Zika virus.

Penn - developed, DNA - based Vaccine Clears Nearly Half of Precancerous Cervical Lesions in Clinical Trial

The Wistar Institute was awarded a $ 1,494,972 grant by the Bill & Melinda Gates Foundation to advance a DNA - based vaccine candidate for protection against malarial infection utilizing a synthetic DNA platform created in the lab of David B. Weiner, Ph.D., executive vice president, director of the Vaccine & Immunotherapy Center at The Wistar Institute and the W.W. Smith Charitable Trust Professor in Cancer Research.

A new generation DNA - based vaccine against Zika virus showed protection from infection, brain damage and death in a preclinical model.

In SIV - infected macaques, Picker's team found that a CMV - based vaccine cleared the virus in 50 % of the monkeys by eliciting and maintaining a powerful, but non-traditional, cytotoxic T - cell response.

The new Ad26 / MVA and Ad35 / Ad26 vector - based vaccine regimens resulted in over 80 % reduction in the per - exposure probability of acquisition of infection against repetitive challenges of SIV, a virus similar to HIV that infects monkeys.

In late June, a different DNA - based vaccine also got the green light for testing in people.

Most recently, the foundation awarded a $ 1.4 million grant to the Wistar Institute in Philadelphia to create a synthetic DNA - based vaccine for malaria.

A Phase 1 study in malaria - naïve North American volunteers found that the AMA1 - based vaccine FMP2.1 / AS02A elicited potent humoral and cellular immune responses and that immune sera recognized sporozoites and merozoites by immunofluorescence assay and inhibited both parasite growth and AMA1 processing in homologous 3D7 parasites [16].

The focus of this application is to develop an adenovirus - based vaccine against rabies virus that can provide rapid immunity following a single administration to achieve prophylactic status and as well as in response to a bioterrorism attack.

The two projects PRIMALVAC and PAMCPH / PlacMalVac aim at the development of a VAR2CSA based vaccine that could be administered to nulligravid women (before first pregnancy) thus inducing a state of protective immunity that is comparable to multigravid women and efficiently prevents subsequent episodes of placental malaria.

We have completed the active phase of a Phase 1 trial of a Vaxwave ® - based vaccine against cytomegalovirus (CMV) and are finalizing clinical development plans for TheraT ® in Human Papilloma Virus (HPV)- related head and neck cancers.

For the vaccine informatics, we developed VIOLIN, a web - based vaccine database and analysis system.

Cell - based Vaccine Manufacturing There has been increasing interest in moving from egg - based vaccine manufacturing to cell culture - based methods.

Dr.. He has initiated and led the developed of many ontologies, including the community - based Vaccine Ontology (VO) and Ontology of Adverse Events (OAE).

Cell - based vaccine manufacturing is quicker, efficiently scalable and offers more control...

The Weiner Laboratory at Wistar is dedicated to accelerating DNA - based vaccine technology.

These findings highlight the need to (a) induce multiple neutralizing antibody lineages for a protective antibody - based vaccine and (b) the potential need to use combinations of purified mAb in therapeutic or prophylactic settings.

But in mice that had been exposed to human adenovirus, only the chimp virus - based vaccine worked, the researchers report in the March issue of the Journal of Virology.

And in a study of monkeys, researchers discovered that a cytomegalovirus - based vaccine protected 50 percent of animals from infection by simian immunodeficiency virus.

Production of an mRNA - based vaccine is also likely to be easier and less expensive compared to traditional virus - or viral protein - based vaccines.»

PowderMed, based in Oxford, is developing a DNA - based vaccine that works by spraying gold particles coated with avian flu genes directly into human skin with high - pressure helium.

The virus - based vaccine seems «a very viable» way to one day treat existing disease in humans, says Fernando Goni at the New York University School of Medicine.

They will also work with Vir Biotechnology, Inc. of San Francisco, which has licensed aspects of their CMV - based vaccine approach, to expand testing with plans to start a human clinical trial in 2020.

This is the first time that a virus - based vaccine has successfully slowed the progression of prion disease, says Federoff.

The only VLP - based vaccine to hit the U.S. market is Merck & Co.'s Gardasil, which won FDA approval in June as preventative against certain types of human papillomavirus (HPV), which could lead to cervical cancer.

It's also a stark contrast to today's egg - based technology, which takes about six months to produce a mere 100 million doses, according to Alan Shaw, CEO of VaxInnate, a company at the forefront of bacteria - based vaccine production.

The cell - based vaccine, which did not have the egg - passage mutations, had a predicted efficacy of 47 percent, the average value of a perfectly matched H3N2 vaccine, Deem said.

He and Bonomo compared the efficacy of the egg - based vaccine with an experimental vaccine produced from insect cells via reverse genetics.

Because the strain of flu that infects people is often difficult to grow in eggs, vaccine producers must make compromises to produce enough egg - based vaccine in time for fall flu shots.

«The vaccine has been changed for 2018 - 19, but unfortunately it still contains two critical mutations that arise from the egg - based vaccine production process,» said Michael Deem, Rice's John W. Cox Professor in Biochemical and Genetic Engineering and professor of physics and astronomy.

• Sanofi (ENXTPA: SAN) will buy Protein Sciences, a Meriden, Conn. - based vaccines biotech company, for an initial amount of $ 650 million, according to Reuters.

A new collaborative project between the University of Helsinki and the French National Centre for Scientific Research (CNRS) is shedding light on the efficacy of environmentally friendly RNA - based vaccines that protect plants from diseases and pests.

This new method will enable the effective production of RNA - based vaccines and promote the development and adoption of RNA - based plant protection methods.

Together with researchers at the CNRS, the group has demonstrated the efficacy of RNA - based vaccines produced using the new method against plant virus infections.

The method is relatively new, but far bacteria - based vaccines have proven effective: A seasonal flu vaccine produced by VaxInnate successfully protected humans in clinical trials, and the company's recently tested swine flu vaccine immunized mice against the virus.

Novavax is not the only company developing VLP - based vaccines, although it is ahead of the game in the category of flu vaccines.

The German biotech CureVac, for example, has brought mRNA - based vaccines for rabies and cancer to clinical trials, and Karikó now heads a research team at BioNTech in Mainz, Germany, that focuses on mRNA - based drugs.

Intervention from wealthy non-scientists such as the philanthropist Mary Lasker drove even deeper investment into animal - based vaccines despite growing evidence of their lack of safety and efficacy.

Worse still, the results suggest it would be a mistake to use adenovirus - based vaccines against other diseases, such as malaria or tuberculosis, in areas where HIV is common.

The finding reopens the question of whether it's a good idea to base vaccines on the cold - related viruses called adenoviruses.

This includes the development of the HPV - based vaccines now licensed to GlaxoSmithKline and Merck for the protection of women against this disease.

«New Zika vaccine candidate protects mice and monkeys with a single dose: Results from study highlight the promise of mRNA - based vaccines and therapies.»

BRUSSELS — CureVac, a company based in Tübingen, Germany, that develops RNA - based vaccines and therapies, has won a $ 2 million prize awarded by the European Commission to stimulate new vaccine technologies that might help the developing world.