Sentences with phrase «basement membrane»
The phrase "basement membrane" refers to a layer of tissue that acts like a barrier between different layers of cells in our body. It helps support and separate our cells, like the floor in a building. It also helps in filtering substances and allows for communication between different cells. Full definition
Here, we provide a brief overview of the molecular composition of basement membranes and the process of their assembly.
science.institut-curie.org
The precise composition of basement membranes, however, varies between different tissues.
The identification of dormant niches in basement membrane microvasculature and how those niches become metastatic in the neovasculature holds important implications for future breast cancer therapies.
Female carriers have abnormal glomerular basement membrane as well, but usually remain healthy until later life when renal failure may occur.
AMSBIO announces the availability of two new formulations of Basement Membrane Extract (BME) known as Cultrex BME 2 (organoid growth matrix) and Cultrex BME 3 (xenograft / tumorgraft matrix).
Figure 2: Nerve cell bodies and fibers labeled with rabbit anti-PGP + donkey anti-rabbit-Cy3 (711-225-152 green), vascular basement membranes labeled with collagen IV + donkey anti-mouse-Cy2 (715-225-150 red) and DAPI - labeled DNA (blue) in jejunum submucosal ganglion.
If your dog has a persistent, drug - resistant corneal ulcer for over seven days, and a comprehensive ophthalmic examination has ruled out foreign bodies, aberrantly positioned eyelashes, or other physical abnormalities, then your pet will likely be diagnosed with Basement Membrane Disease.
The other one, the finding by the Clevers group in Utrecht that adult Lgr5 + stem cells from the intestine, grown 3D in the presence of basement membrane matrix and a defined set of niche factors, can develop into ever - expanding, genome - stable 3D organoids that resemble the structure and function of the original intestinal epithelium (13 - 16).
A tumor that has penetrated the epithelial basement membrane and spread to new sites / tissues in the body.
One is a breakdown after injury of the so - called basement membrane, a layer between the epidermis and the dermis that normally keeps tissues separate.
Basement Membrane Disease is a condition in which the epithelium (surface of the cornea) does not adhere properly, and results in chronic, painful, non-healing corneal ulcerations.
SV = Secretory vesicle; RER = Rough endoplasmic reticulum; BM = Basement membrane; MFG = Milk fat globule; CLD = Cytoplasmic lipid droplet; N = Nucleus; PC = Plasma cell; FDA = Fat - depleted adipocyte; TJ = Tight junction; GJ = Gap junction; D = Desmosome; ME = Myoepithelial cell.
Instead of an organized basement membrane, there was a blastema — a circular arrangement of highly proliferative, undifferentiated cells that grew until the tissue was replaced — without scarring.
The ability of the endothelial cells to form capillary - like structures was assessed by placing them on the solubilized basement membrane preparation Matrigel (Becton Dickinson, San Jose, CA), according to the manufacturer's instructions.
A novel basement membrane - induced gene identified in the human endometrial adenocarcinoma cell line HEC1B.
This protocol video demonstrates how to surface - coat cell culture plates and transwell inserts with Cultrex ® Basement Membrane Extract, also called Cultrex ® BME.
B - E) Differential gene expression profiles of molecules involved in extracellular matrix production in Terc - / - BMSCs — notable genetic molecules were related with ECM collagens, basement membrane constituents, ECM proteases, ECM protease inhibitors and other molecules associated with ECM.
Even though basement membranes represent physical barriers that delimit different tissues, they are breached in many physiological or pathological processes, including development, the immune response, and tumor invasion.
The researchers then devised an assay that deployed native basement membrane to separate cancer cells on one side and fibroblasts embedded in collagen on the other.
A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.
«Tumor growth, invasion, and metastasis are multistep processes» that includes not just cell proliferation, but invasion through the surrounding tissue, and «migration through basement membranes» to reach the bloodstream before the tumor can establish «new proliferating colonies» of cancer cells.
Green: podocyte, Red: glomerular basement membrane.
Ganka Nikolova (Lammert, MPG)-- «The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation» (2006)
Malignant tumor that is invading adjacent structures, but has not yet penetrated the epithelial basement membrane.
Collagen IV networks are ancient proteins of basement membranes that underlie epithelia in metazoa from sponge to human.
When Heber - Katz looked at the filled - in holes under the microscope, she noticed a breakdown in the basement membrane — the thin layer of cells that connects the dermis (the cushiony subcutaneous connective tissue) to the epidermis (the skin's outer layer).
«This is a significant study because it is the first report of a basement membrane protein playing a role in enamel mineralization,» said JDR Associate Editor Joy Richman.
«I said «Hey, why don't we put these things in something that looks like a basement membrane?
Previous research by Bissell and her group showed that the basement membrane, the thin layer of extracellular matrix proteins surrounding breast and other epithelial tissue, provides a microenvironment that induces quiescence in normal epithelial cells and dormant tumor cells alike.
Given that breast cancer cells traveling through the bloodstream on their way to secondary sites where breast tumors metastasize most often — lung, bone marrow, brain and liver — must first pass through the basement membrane microvasculature, Ghajar and Bissell suspected that the basement membrane could be a major component of the dormant niche in distant organs.
Fibrous collagen is not normally found in the basement membrane that surrounds the mammary epithelium, so any collagen signaling could confound the conclusions of those studies.
When the extracellular matrix is very flexible, or when a high concentration of laminin is readily available, proteins called α6β4 integrins within the cell membrane bind with laminin to form small structures called hemidesmosomes, which anchor the epithelial cells to the basement membrane.
Further experiments indicated that the cells would recover their normal behavior in high - stiffness gels if they were exposed to increasing concentrations of laminin, a protein naturally found in the basement membrane.
They also prevent the breakdown of the basement membrane.
It hinders heparanase in eroding the basement membrane.
According to Parish, one way to stop the migration of leucocytes is to disrupt the process by which they «chomp through the basement membrane».
Leucocytes get through the basement membrane by binding to it and then locking on to a host of membrane - degrading enzymes found in blood cells.
«It has the potential to largely reduce the complexity in diagnosing and monitoring anti-GBM (glomerular basement membrane) diseases.
Corresponding to the primary function of epithelial tissues, i. e. forming a barrier between compartments, epithelial cells form tight adhesions between each other, and display only lateral mobility, confined by the basement membrane.
Thus, epithelial tumor cells must undergo phenotypical changes that allow them to breach the basement membrane, invade adjacent tissues and ultimately form distant metastases.
Research Interests: Kidney disease; HIV - associated nephropathy; APOL1 biology; Podocyte biology and kidney development; Basement membranes and extracellular matrix biology; Eukaryotic gene regulation
Laminins are tissue - specific glycoproteins in the basement membrane, important for cell proliferation, migration and differentiation, and tissue development.
First, breast CSCs were shown to invade through Matrigel, a basement membrane matrix used routinely as an indicator of metastatic potential of cancer cells [14].
Confocal images of sections of the seminiferous tubules illustrated the existence of various iPS cell - derived EGFP - positive cells, including flattened fibroblast cell - like myoid at the outermost layer of the tubules, spermatogonial stem cells with spherical nuclei closest to the basement membrane and spermatocytes with distinctive chromatin closer to the lumen than spermatogonial stem cells (Figure 6D).
Attachment of a peptide to the other end of PEG targets the nanoparticle to a collagen protein found in the vascular basement membrane that becomes exposed with vascular injury and inflammation.
The basement membrane (BM) is a dense, tightly cross-linked matrix that acts as physiological barrier to maintain tissue homeostasis.
At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from the stroma.
Researchers at the Institut Curie in Paris now say that they have evidence of a coordinated attack on the basement membrane by cancer cells in situ and CAF cells in the extracellular matrix that begins long before the actual translocation of cancer cells.
Invasive cancer cells are believed to breach the basement membrane (BM) using specialized protrusions called invadopodia.