Sentences with phrase «basic mechanisms of the disease»
«In order to make good therapies we have to understand the basic mechanisms of the disease,» McKee argued.
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Kathleen Kelly, a cancer biologist at NCI, is optimistic that the work will enhance understanding of the basic mechanism of the disease.
In both types there is a failure to regulate blood sugar, but the basic mechanisms of disease differ between the two.
Not exact matches
Basic and translational research investigates mechanisms of disease, which can help develop better diagnosis and treatment strategies.
He finds «growing interest in industry to engage with universities to address basic research problems, to enhance basic knowledge of disease mechanisms.»
This basic fact makes it difficult for researchers to discern the underlying mechanism of the disease: «It's very difficult to figure out what's wrong, because the bone marrow is nearly empty of these cells,» said Bessler, the director of CHOP's Pediatric and Adult Comprehensive Bone Marrow Failure Center.
However, many industry insiders say these changes are opening up unique opportunities for researchers who focus on translating basic science into real - world cures and are eager to explore the molecular mechanisms of disease, test hypotheses, and do work that benefits patients.
If I had gone that other route, I would most likely be studying basic mechanisms of immunity rather than applying them to the study of infectious and autoimmune disease models.
The Center's goal is to understand basic mechanisms of tissue and organ formation, and then to use this knowledge to regenerate, repair, and replace tissues damaged by aging, disease and injury.
But translation is not one - way; the insights gained at the bedside, and from clinical and population - based studies, will spawn hypotheses, enabling scientists to probe the mechanisms of disease in new ways and ultimately enriching basic biology.
«Clearly, there are basic molecular mechanisms of aging that cause the various diseases that disable and ultimately kill us.»
Not long after the IOM report was published, NIH issued its own written assessment, concluding that research has neglected many of the biological factors behind ME / CFS and urging more basic science aimed at teasing out the mechanisms of the disease.
Palmer said the multi-site registry will help doctors who treat patients with idiopathic pulmonary fibrosis better understand how to diagnose and manage the disease, while it will also help researchers uncover the basic causes and mechanisms of the disease.
The application to monogenic diseases also encompasses numerous topics of basic research, including the definition of the pathological mechanisms, the identification of the biomarkers, etc...
The three - year fellowships provided training, under the guidance of mentors, in research directed toward an understanding of basic biological processes or disease mechanisms.
He has led a well - regarded basic research program into mechanisms of plant disease and plant disease resistance, for which he was elected EMBO member in 1999 and FRS in 2003.
Identification of genes that contribute to Alzheimer's disease risk and that influence other characteristics of Alzheimer's disease will reveal basic pathogenic mechanisms, identify proteins and pathways for drug development, and provide genetic methods for determining people at greatest risk for when preventative measures become available.
Research in the Immunology, Microenvironment and Metastasis program is aimed at 1) merging basic mechanistic understanding of multidisciplinary pathways of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.
His research interests focus on understanding basic underlying mechanisms of ocular angiogenesis and identifying therapeutic approaches to treating neovascular eye diseases such as macular degeneration and diabetic retinopathy.
Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.
Our objective is to uncover fundamental insight into basic and biomedical science through rigorous investigation of the genetic mechanisms governing organogenesis and diseases.
It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), works.
Based on basic transcriptional studies of midbrain dopamine neurons, Dr. Kim's lab identified the orphan nuclear receptor Nurr1 as a potential drug target of Parkinson's disease (PD) to develop novel drug candidates for neuroprotective and mechanism - based therapeutics.
We help our clients better understand the function of genes, basic mechanisms of biology, pathophysiology of diseases, to identify and validate new drug targets and to perform risk assessment in drug development.
His areas of research include basic mechanisms of retinal cell death in glaucoma, neuroprotective glaucoma therapies, non-invasive imaging of glaucoma damage, and relationships between glaucoma and other chronic neurodegenerations such as Alzheimer's disease.
Targets of research range from basic molecular and cellular mechanisms, the manipulation of these mechanisms in animal models, analyses of the genes and gene products in cardiovascular disease, and clinical research that seeks to improve diagnosis and therapy for patients.
From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
Overall, the Center seeks to implement a comprehensive approach to define the basic mechanisms of cardiovascular disease and to translate these insights to patient care.
We have therefore built a highly collaborative team in which basic scientists — focused on unraveling the fundamentals of disease mechanisms — interact fluidly with physician - scientists like myself, who bring the critical patient perspective to our research.
We plan to extend this discovery by developing a model of TBK1 glaucoma that will facilitate studies of the basic mechanisms by which defects in genes cause the disease.
«I think uncovering this mechanism is an important basic discovery that could lead to tangible ways of thinking about design of therapeutic approaches for neurodegenerative diseases in the near future,» said Haghighi.
Hence, defining the mechanisms that control their occurrence is crucial to our basic understanding of genome biology, evolution, and disease mechanisms.
Our strategy is to identify basic mechanisms of proteins involved in metabolism and DNA repair to gain better understanding in disease and also develop small molecule inhibitors to selectively targeting these proteins as potential therapeutics.
«In fact, chronic itch is a disease of the nervous system manifested in the skin, but we understand very little about basic mechanisms and effective treatments.»
Comparative Orthopaedics Laboratory Dr. Alan Nixon's laboratory is dedicated to the study of the basic mechanisms of orthopedic diseases and the development of innovative therapies.
The laboratory provides a focus point for the dedicated study of the basic mechanisms of orthopedic diseases and the development of innovative targeted therapeutic measures.
Both clinical and basic research are highly valued and faculty strive to enhance the diagnosis, treatment and prevention of animal disease, promote animal health and productivity, and take advantage of our unique access to naturally - occurring clinical disease in order to explore mechanisms of fundamental importance to biomedical science.