There is a genetic
basis for the disease and it appears to be inherited as an autosomal recessive.
The advent of molecular cloning, DNA sequencing and the many tools of molecular genetics and cell biology has given us sufficient knowledge of
the basis for disease and the genes to target, but what has limited the application of gene therapy has been efficient gene delivery systems.
Theoretically, this precise molecular characterization of human disease will allow us to understand
the basis for disease susceptibility and environmental influence; to offer an explanation for the different phenotypic manifestations of the same disease; to define disease prognosis with greater accuracy; and to refine and, ideally, individualize disease treatment for optimal therapeutic efficacy.
Additionally, since ribosomal RNA has been shown to have specified controlled of cellular fate, this study provides a theoretical
basis for disease therapy and neuroscience research and may lead to future advances in treating degenerative diseases or even brain cancers.
«These people have a very strong genetic
basis for the disease,» Reaven says.
Ultimately the IMPC program will provide information on the function of all genes and genetic networks and a powerful dataset that will underpin fundamental new insights into the genetic
bases for disease.
Not exact matches
That means that,
for the first time ever, Americans won't have to get a prescription to receive plain - English medical reports about their chances of developing
diseases like Alzheimer's, Parkinson's
disease, celiac
disease, and other disorders
based on analyses of their genetic makeup.
Danish pharma company Novo Nordisk (nvo), best known
for its insulin -
based treatments
for diabetes, said Tuesday it's going to shift its focus slightly to fighting obesity, one of the primary causes of that
disease.
• Rani Therapeutics, a San Jose, Calif. -
based developer of a pill designed to replace injectable drug delivery
for patients suffering from chronic
diseases, raised $ 53 million in funding.
And Xenon, a Vancouver -
based biotech, completed a US$ 31 - million private equity financing last April that will allow it to further develop its product pipeline, which consists of small - molecule therapies
for select neurological, cardiovascular and metabolic
diseases.
But before his arrest, he said he'd use KaloBios as a vehicle to nab another niche drug, this time
for treatment of the parasitic infection Chagas
disease, and dramatically increase its price to the $ 60,000 to $ 100,000 range after helping it win FDA approval (the drug is approved in other countries and is provided to patients in the U.S. on a special and selective
basis).
This San Francisco -
based startup is a group of scientists and engineers working to develop new technologies
for people with Essential Tremor and Parkinson's
disease, a demographic that includes millions of people whose hands shake so much that just getting food into their mouths is a challenge.
• Kala Pharmaceuticals, a Waltham, Mass. -
based biotech focused on treating eye
diseases with nanoparticles, filed
for an $ 86 million IPO Friday.
• Clementia Pharmaceuticals, a Montreal, Canada -
based clinical stage biopharmaceutical company focused on bone
diseases, filed
for an IPO to raise $ 115 million.
• Biohaven Pharmaceuticals, a New Haven, Conn. -
based neurological
disease drug developer, set terms
for its IPO.
Shares in Nedlands -
based Proteomics International Laboratories skyrocketed on news it had produced and validated a predictive test
for the diagnosis of diabetic kidney
disease.
Competition: Most of the venture capital
for synthetic biology applications has gone to companies like Seattle -
based Juno Therapeutics, which does genetic engineering to help patients fight
disease.
In recent years, Levine and others have used clinical studies to prove that even in healthy people, a chair -
based lifestyle sets up the physiological conditions
for the onset of Type 2 diabetes, cardiovascular
disease, obesity — and ultimately, shorter lifespans.
• Excision BioTherapeutics, a Philadelphia -
based life science company focused on the development and commercialization of advanced gene editing therapeutics
for the treatment of life - threatening
disease caused by neurotropic viruses, raised $ 10 million in seed funding.
Systems science is an interdisciplinary field that studies how the interaction of factors produces outcomes — how the causes and consequences of events can, taken together, form the
basis for everything from a
disease epidemic, to a pattern of human behavior.
That knowledge provides a
basis for identifying
disease - resistant genes in wild and cultivated bananas.
• Kala Pharmaceuticals, a Waltham, Mass. -
based biotech focused on treating eye
diseases with nanoparticles, raised $ 90 million in an offering of 6 million shares
for $ 15 a piece.
The researcher's formula to determine the right diet
based on an individual's microbiome might be good news
for people at risk
for diseases associated with being overweight or obese.
• Oyster Point Pharmaceuticals Inc., a San Francisco -
based developer of treatments
for dry eye and other
diseases of the ocular surface, raised $ 22 million in Series A funding.
Last spring, Toronto -
based Klick, a privately owned marketing agency focused on the health care industry, unveiled a wearable device that digitizes the tremors of someone suffering from Parkinson's
disease then recreates them
for someone else to feel first - hand.
• Smith & Nephew agreed to acquire Rotation Medical, a Plymouth, Minn. -
based developer of treatments
for rotator cuff
disease, from Pappas Capital
for $ 125 million.
Aldeyra Therapeutics, a Burlington, Mass. -
based developer of therapies
for rare eyes and skin
diseases, raised $ 12 million in its IPO.
At the Challenge Festival, startups like as BaseTrace, which «uses DNA -
based tracers to track where industrial fluids are going in large, complex environments» and Reliefwatch, a cloud -
based system that uses smartphone technology to track inventory and
diseases for healthcare organizations in the developing world, battled it out on stage
for a grand prize of $ 150,000 in investment.
• Metactive Medical Inc, an Olathe, Kansas -
based developer of products
for the treatment of neurovascular, peripheral vascular and structural heart
diseases, raised $ 1.2 million in Series A funding.
• Alzheon, a Framingham, Mass. -
based biopharmaceutical firm developing Alzheimer's
disease, filed
for an IPO of up to $ 80.5 million.
Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a
basis for a variety of commercialization opportunities to help solve aging related
disease and human biological decline.
And as
for everyone arguing that we're suffering from «Dutch
disease», just ask Ontario's manufacturing sector what's actually screwing them: exchange rates, OR fundamental flaws in our one - customer, tied - to - the - US economy manufacturing
base?
A spokesperson
for Facebook directed Newsweek to its community standards on hate speech, which said that the platform «removes hate speech» that directly attacks people
based upon «race, ethnicity, national origin, religious affiliation, sexual orientation, sex, gender, or gender identity, or serious disabilities or
diseases.»
About ChipCare ChipCare is a Toronto -
based company producing life - saving diagnostics
for infectious and non-communicable
diseases in remote health settings with a mobile, simple - to - use & lab quality blood - testing platform.
(Reuters)- Alnylam Pharmaceuticals Inc's RNAi -
based drug that targets a rare genetic
disease met the main goal of a key study, in a breakthrough
for the new class of medicines that works by blocking
disease - causing proteins.
But it has been disappointing in that the kind of genetic variation it detects has turned out to explain surprisingly little of the genetic links to most
diseases... One issue of debate among researchers is whether, despite the prospect of diminishing returns, to continue with the genomewide studies, which cost many millions of dollars apiece, or switch to a new approach like decoding the entire genomes of individual patients.The unexpected impasse also affects companies that offer personal genomic information and that had assumed they could inform customers of their genetic risk
for common
diseases,
based on researchers» discoveries...
Based on some of the arguments Grossman made about how administrative efforts to prevent sexually transmitted
disease actually lead to more sexual activity, more
disease, and more psychological distress, Nava penned an op / ed
for the Daily Princetonian questioning the campus's programs on condom distribution and sexual health titled «Princeton's Latex Lies.»
For example, modern knowledge
based on scientific discovery shows us that
disease is not caused by evil spirits, so why believe in ancient creation myths which are shown to be incorrect.
I have instructed the Secretary of Health, Education, and Welfare to: Appoint an advisory committee on alcoholism; establish in the Public Health Service a center
for research on the cause, prevention, control, and treatment of alcoholism; develop an educational program in order to foster public understanding
based on scientific fact; work with public and private agencies on the state and local level, to include this
disease in a comprehensive health program.
People refusing medical treatment because they think they can pray
disease away, The demoralizing way religion makes you feel about yourself (I am a wretch, a sinner, a bad person by nature), the religious wars that have been fought
for millenia, the self righteous passing laws
based on THEIR beliefs (change to the pledge of allegience which now excludes anyone who does not believe in a fairy godfather, the change to the national motto that turned it into the lie «in god we trust», the bigotry that «my religion is the right one and you are wrong so I'll pray
for you» kind of crap... don't you realize that it is insulting to me when someone says they will pray
for me... its the same as saying I'm going to do something
for you but there won't be any effect, so it is just a waste of time.
Last week, Pat Robertson told his viewers that he believes Alzheimer's
disease to be a «kind of death,» a
basis for the un-afflicted spouse to seek divorce and move on with their life — so long as they act mercifully and provide a means
for care of that spouse.
His article is
based on a speech he presented to an October meeting of religious journalists sponsored by the National Leadership Conference on AIDS, the Centers
for Disease Control, and the Associated Church Press.
Despite a nationwide drop in abortions, Planned Parenthood's rates remain steady as it gains market share; meanwhile, the number of patients seen annually has dropped from 3 million to 2.4 million since 2008, due to fewer women coming in
for other services, according to the NRLC report, which is
based on numbers from Planned Parenthood, the affiliated Guttmacher Institute, and the US Centers
for Disease Control and Prevention (CDC).
(Over 90 percent of abortions take place much earlier in a woman's pregnancy, before 14 weeks,
based on Centers
for Disease Control data.)
Diagnoses were made on the
basis of symptoms, and persons with a certain cluster of symptoms were given a label in the conviction that a particular cause might be found
for that «
disease.»
Definition of CULT 1: formal religious veneration: worship 2: a system of religious beliefs and ritual; also: its body of adherents 3: a religion regarded as unorthodox or spurious; also: its body of adherents 4: a system
for the cure of
disease based on dogma set forth by its promulgator 5a: great devotion to a person, idea, object, movement, or work (as a film or book); especially: such devotion regarded as a literary or intellectual fad b: the object of such devotion c: a usually small group of people characterized by such devotion
According to the Centers
for Disease Control and Prevention, you need to consume 28 grams of fiber per day,
based on a typical 2,000 - calorie diet.
In one study that followed people from the Netherlands
for 10 years, orange and yellow hued veggies, carrots in particular, were shown to significantly reduce the risk of cardiovascular
disease when eaten on a regular
basis.
Real food must nourish the body and help fight
disease and sickness on a daily
basis, but a fulfilled life is one to be enjoyed, which
for me includes great company and good meals.
That's just one of the reasons FloraGLO is trusted most by doctors —
based on the results of the National
Disease and Therapeutic Index syndicated report among physicians who recommend a dietary supplement with lutein
for eye health between September 2009 and September 2010 — and is the brand being used in the National Eye Institute's AREDS 2 trial.