Sentences with phrase «basis of human disease»

Articles cover the genetic basis of human disease including germline cancer genetics, the clinical manifestations of genetic disorders, applications of molecular genetics to medical practice.

As a result, the major mechanisms that underlie the contributions of non-coding variants to the genetic basis of human disease have yet to be clearly established.

We are at the initial stages of understanding the genetic basis of human disease and evolution at all levels.

His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.

Ageing research and more generally the study of the functional basis of human diseases profit enormously from the large - scale approaches and resources in mouse functional genomics: systematic targeted mutation of the mouse genome, systemic phenotyping in mouse clinics, and the archiving and distribution of the mouse resources in public repositories.

This centre has been devised as a space for excellence research in genomic medicine, focussing on the comprehensive study and understanding of the genetic basis of human diseases in general, placing special emphasis on cancer and its genetic disorders related to inheritance.

These DNA — based tests were originally developed to study the basis of human diseases and became available for dogs in 2007.

Not exact matches

Systems science is an interdisciplinary field that studies how the interaction of factors produces outcomes — how the causes and consequences of events can, taken together, form the basis for everything from a disease epidemic, to a pattern of human behavior.

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

Beyond the university - based experts who also came from Harvard and the University of Pittsburgh, U.S. symposium participants in Havana were from Memorial Sloan - Kettering Cancer Center, the Roswell Park Cancer Center, both in New York State, the Moffitt Cancer Center in Florida and the Ponce Research Institute in Puerto Rico, as well as the U.S. Department of Health & Human Services, the National Cancer Institute, and the Centers for Disease Control and Prevention..

Building the knowledge base requires humans to teach computers key concepts from curated articles; with modest online training, anyone who reads English can scan research papers for key terms — names of genes, proteins, diseases, and drugs — and use online marking tools to document relationships between them (for example, drug X treats disease Y).

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

Under the next White House Administration, Holdren said, science - based challenges that will require sustained, robust investment include efforts to ensure safe and sustainable food, water, and energy for everyone, reduce greenhouse gases, minimize harm from climate change already underway, combat diseases such as Zika, defeat cancer, improve quality - of - life for those who are aging, prevent devastating asteroid impacts, and send humans into space «not just to visit, but to stay.»

The virus - based vaccine seems «a very viable» way to one day treat existing disease in humans, says Fernando Goni at the New York University School of Medicine.

JUDY MIKOVITS HAD BEEN SO COCOONED IN the world of AIDS that she had never heard of chronic fatigue syndrome until 2006, when she was hired to consult for a Santa Barbara — based foundation supporting investigation into human herpes virus six (HHV6), which had been implicated in the disease.

The human cell - based disease model is expected to lead to a better understanding of these disorders and other illnesses, Hsiao said.

The findings also point to the potential for new therapies for lupus and other autoimmune disease based on inhibiting the action of EBNA2 or other human proteins that bind to DNA at the same loci along with the viral protein, the researchers say.

«We are analyzing massively large sets of human genomic data to ultimately improve our understanding of genetic basis of diseases.»

«Our results indicate that based just on the pattern of virus attachment the H7N9 currently emerging in China has the potential both to cause severe pulmonary disease and to be efficiently transmitted among humans,» says Dr. Kuiken.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Suspecting that the disease works differently in humans, whose brains are much bigger and more complex than those of lab animals, Brivanlou, along with research associates Albert Ruzo and Gist Croft, developed a cell - based human system for their research.

The gift accompanies a paper published online today in Nature from researchers at Broad and worldwide, which identifies more than 100 areas of the human genome associated with schizophrenia, based on samples from almost 37,000 people with schizophrenia and about 113,000 without the disease.

The internet - based outbreak reporting system — which reports on human, animal, and plant disease outbreaks — operates under the auspices of the International Society for Infectious Diseases.

On the basis of those results, at least one company is attempting to replicate the effect in humans using blood plasma from healthy young people to treat patients with Alzheimer's disease.

He added that the existence of episodic memory in lower animals has implications for research on human diseases that affect memory, including Alzheimer's, Parkinson's and Huntington's diseases, since the majority of research on the brain — and the drugs used to treat memory diseases and dementia — start out based on insights into how the brain works in rats.

In recent years, interest in this fifth DNA base has increased by showing that alterations in the methyl - cytosine contribute to the development of many human diseases, including cancer.

Because the molecule must be injected into the brain, this kind of chemical - based fMRI won't be applied to humans anytime soon, says Jasanoff, but it could be used to probe addiction and disease using animals.

He was the first to argue that diagnosis, prognosis, and treatment of a disease must be based on comprehensive knowledge of human anatomy.

Earlier versions of these «base editors,» which target typos related to the other half of disease - causing genetic spelling errors, have already been used to alter genes in plants, fish, mice and even human embryos.

The new study is based on the development of mouse models manifesting the disease that causes megalencephaly, spasticity and ataxia in humans.

As part of the precision medicine initiative at the Cancer Institute of New Jersey, investigators — which include colleagues from Rutgers Robert Wood Johnson Medical School and RUCDR Infinite Biologics, the world's largest university - based biorepository, located within the Human Genetics Institute of New Jersey — wanted to define the relationship of ERBB2 alterations in the pleomorphic form of the disease.

Theoretically, this precise molecular characterization of human disease will allow us to understand the basis for disease susceptibility and environmental influence; to offer an explanation for the different phenotypic manifestations of the same disease; to define disease prognosis with greater accuracy; and to refine and, ideally, individualize disease treatment for optimal therapeutic efficacy.

«I am skeptical about the completeness of the evolutionary story when it is based exclusively on the remnants of human disease isolates.»

The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community.

This blueprint should come in handy in sussing out the molecular basis of human variation and disease and in discovering potential new treatments.

The purpose of this perspective is to provide a logical basis for a new approach to classifying human disease that uses conventional reductionism and incorporates the non ‐ reductionist approach of systems biomedicine.

«The microscope lets us examine cells on an individual basis, much as we would human patients,» said Finkbeiner, director of the Taube / Koret Center for Neurodegenerative Disease Research.

A total of 22 mouse mutant lines can be characterised through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

The Clinical Research Forum Board of Directors selected winners based on the degree of innovation and novelty involved in the advancement of science; contribution to the understanding of human disease and / or physiology; and potential impact upon the diagnosis, prevention and / or treatment of disease.

The Center, which collaborates with CiRA, is creating human, iPS - based disease models needed to accelerate drug development for a host of devastating for cardiovascular, viral and neurological illnesses.

With advanced technology based on this discovery, scientists can now edit the genomes of human cells to learn what causes intractable diseases — and find new ways to treat or cure them.

University of Dayton biologist Amit Singh is studying early eye development in fruit flies to understand the molecular basis of retinal disease and birth defects in the human eye under a new $ 439,499 grant from the National Institutes of Health.

The strategy developed by research teams and development of I - Stem aims to identify innovative therapies applicable to rare genetic diseases based on exploring the potential offered by human pluripotent stem cells.

«This agreement is a part of deCODE's ongoing strategy to unleash the value of human genetics,» said Kari Stefansson, founder and CEO of deCODE, «our research platform allows us to understand the genetic basis of disease and modifiers of clinical phenotypes in actual patient populations; by doing so, we can rapidly move from targets to patient stratification and from there to companion diagnostics.»

Major focus areas include human genome interpretation and genetic dissection of novel rare diseases, predictive genomic signatures of response to therapy — especially cancer therapy, and novel sequencing - based assays as biomarkers of disease.

He is based at the University of Oxford, where he leads a group that is using large - scale human genetic data to improve prediction, prevention and treatment of disease.

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

Researchers have unraveled the molecular basis of many human disorders, and a very large part (over 80 percent) of the genes we know to be associated with human disease (e.g. Parkinson's and addiction) have homologues in zebrafish.

It is based on the scientific understanding and high - throughput analyses of human immune responses to disease - related proteins in selected populations including elderly with the capability to stay healthy during the aging process.

PHENOMIN - ICS services will ultimately help the scientific community in the use the mouse model, first to develop a complete functional annotation of the human genome and second to better understand human diseases and their underlying physiological and pathological basis.