Although the human cells
became glial cells (the brain's scaffolding) and not neurons, the mice unexpectedly became four times as smart as regular mice, as measured by how well they ran mazes and other tests.
Not exact matches
The mice benefited from human stem
cells called
glial progenitors, immature
cells poised to
become astrocytes and other glia
cells, the supposed support
cells of the brain.
UW Medicine researchers have now prompted
glial cells to
become functional interneurons in mouse retinas.
Monje first
became interested in neurons» role supporting tumors while working on childhood glioma, a cancer that strikes in the precursors to
glial cells in the developing brain.
When the brain is harmed by injury or disease, neurons often die or degenerate, but
glial cells become more branched and numerous.
In the healthy brain, stem
cell - like
glial progenitors can divide, migrate to an injured site, and
become mature oligodendrocytes after myelin loss, but, unfortunately, the efficiency of remyelination declines with age.
What we've discovered is that those
cells become active very early in the disease, they
become active even before we can detect that the neuron is sick, even before the ganglion
cell shows signs of degenerating, we find the
glial cells are
becoming very, very active and that was a surprise and we published those findings.
Strangely enough, its not the neurons (brain
cells) that
become cancerous, it is the
cells supporting the neurons, called
glial cells, that cause the problem.