Sentences with phrase «because humans and mice»

For example, he says, because humans and mice have different metabolic rates, lower doses may have similar beneficial effects in humans.

«Because humans and mice have similar responses, mice may be a good model for studying this further.»

Not exact matches

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

Scientists aren't always thinking about the genetic differences between mice and humans because they're focused elsewhere.

«Ninety to 95 percent of cervical cancer cases are HPV - related, and there are very few studies of this type of cancer in mice because HPV is a human virus,» Schwarz said.

Part of the problem, he says, is that the incidence of many human chronic diseases rises with age, yet many researchers prefer using young mice because of the pressures of being published and getting funding.

The summary of his experiment that Gage sent to the neuroscience meeting did not specify the size of the human brain organoids he and his colleagues implanted into mice; he told STAT that he could not talk about the work because he had submitted it to a journal.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

«This is primarily because of the difference between the mouse and human immune systems.»

The authors said that this result suggests that the reason bacterial numbers are so high in these mice, and, by extension, human LAD patients, is not because of a defect in the immune system's surveillance mechanism but because of the inflammation caused by the immune system's abnormal response to normal levels of bacteria in the gums.

These are not genes but must have an important role because evolution has left them virtually unchanged in both humans and mice since our evolutionary paths parted about 75 million years ago.

Studying aging and its associated diseases has been challenging because existing vertebrate models (e.g., mice) are relatively long lived, while short - lived invertebrate species (e.g., yeast and worms) lack key features present in humans.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

This is because the tumors in mice mirror the genetics as well as the molecular and cellular properties of tumors in humans.

«These results are especially exciting because they show that we can take findings in the mouse and possibly apply them at the human patient population,» said Koenig.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

But he cautions that mouse and human livers aren't the same; what's more, whereas Atkins - like diets seem to work in humans because they eat less, mice lose the weight through exercise.

For the animal study, the researchers separated 52 mice with colon cancer tumors into three groups, including a control group and groups that were fed either the grape compounds or sulindac, an anti-inflammatory drug, which was chosen because a previous study showed it significantly reduced the number of tumors in humans.

Belury and colleagues were able to tie these findings to the human tendency to skip meals because of the behavior they expected to see — based on previous work — in the mice on restricted diets.

Because neurogenesis surges in newborn mice and humans and then tapers to a slow trickle by adulthood, Frankland and colleagues wondered if that explosion of new neurons could help explain the widespread phenomenon of infantile amnesia — the inability of adults to remember events that occurred before they were 2 to 4 years old.

Because they are interested in human heart failure, Lavine and his colleagues developed a method to progressively damage mouse cardiac tissue in a way that mimicked heart failure.

Previous attempts to do the same in monkeys, however, have failed — a disappointment because monkeys are more similar than mice to humans, and thus likely a better harbinger of how stem cell treatments will fare in people.

(Most of the research is still being done on mice and other organisms because human tests will take decades to complete.)

Because humans have the «identical circadian clock machinery» as mice, adds Bass, the work has important implications for scientists studying obesity and diabetes in people.

«Our results are important because the process works in mice and in human muscle cells.»

Because mice with intact immune systems are resistant to S. stercoralis infection, the researchers began with an immunocompromised strain of mice, and then exposed some to a synthetic steroid called methylprednisolone (MPA) that is commonly used to treat asthma in humans.

Because of the difficulties involved in harvesting and culturing adult human neurons, most research on DRG neurons has been done in mice.

Embryonic stem (ES) cells, harvested from three - and - a-half-day-old mouse embryos or five - and - a-half-day-old human embryos, are referred to as pluripotent because they can become any of the thousands of cell types in the body.

The findings have implications for all aspects of medical and scientific research because laboratory mice underpin studies whose results have a transformative effect on human and animal lives through vaccination and other immune - based therapies.

The clinical applications are much more remote, because mouse and human germs cells develop differently and may require different conditions.

Because of altered Fgfr2 splicing, cells of the stria vascularis are missing in Esrp1 - deficient mice, and possibly in humans.

The findings suggest that like (some) humans, mice and other animals may simply exercise because they like to.

Because the mouse and human brains have much in common, co-lead study investigator William Muñoz, an MD - PhD student at NYU Langone, says the team's findings advance the field's understanding of how the brain processes touch, smell, hearing, sight, and taste.

Ross says that because the hyperactivity and decreased anxiety might be interpreted as «mania - like» symptoms, the researchers fed the mice either lithium or valproic acid (an anti-seizure drug, also used to treat mania) over a two week period, as is often done in human therapeutic trials.

Liang thinks rats make better models of human feeding behaviors than mice because rats are bigger mammals and eat significantly more than mice, making it easier to measure their food intake.

-- Mice and humans both have about 30,000 genes - and share 99 % of them - but the mouse genome is shorter than that of humans (2.5 billion letters compared with 2.9 billion)---- About 1,200 new genes have been discovered in the human because of mouse - human genome comparisons.

Because the mouse and human brains have much in common, co-lead study investigator William Muñoz, an MD / PhD student at NYU Langone, says the team's findings advance the field's understanding of how the brain processes touch, smell, hearing, sight, and taste.

That's because most studies on single human brain cells use dead rather than living tissue, and many others rely on cells from common laboratory animals, especially mice.

The germ cells made from stem cells stopped differentiating in the mice before they produced mature sperm (likely because of the significant differences between the reproductive processes of humans and mice) regardless of the fertility status of the men from whom they were derived.

The findings, and the techniques used to document them, are important to archaeological research in a broader sense because they lend further support to the idea that fluctuations in ancient mouse populations can be used as a proxy for tracking ancient shifts in human mobility, lifestyle and food domestication.

«We have to optimize how we can deliver these tools because obviously, unlike the mouse, we can't rely on genetic engineering to optimize humans for CRISPRi and CRISPRa.»

This was thought to be the case because there were mutant Pax3 proteins in mice and humans that had defects in the parts of the protein that bind to DNA, and so, would not be able to properly turn genes «on» or «off.»

And, while the genetically - modified mice were made somewhat better by deactivating the HD gene in their hypothalamus, this approach isn't useable in human HD patients because their HD genes don't contain the sequences needed to turn them off with virus used by Petersen and colleaguAnd, while the genetically - modified mice were made somewhat better by deactivating the HD gene in their hypothalamus, this approach isn't useable in human HD patients because their HD genes don't contain the sequences needed to turn them off with virus used by Petersen and colleaguand colleagues.

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

Researchers at Georgetown University Medical Center have taken tissue from human testicles that produce sperm, grafted them onto diabetic mice and showed that blood sugar levels can be controlled for up to a week because they produce insulin.

Because the symptoms resemble human typhoid fever caused by STM, mice infected by STM provide a model system to investigate the development and immunology of typhoid fever in humans.

There are lots of different HD mice available, and because every case of HD is caused by the same basic genetic mutation, it may be that «our» mice will turn out to be better than those of other diseases, at predicting success in human patients.

The lab chose to use the TCL1 mouse model to study B - cell leukemia because ~ 90 percent of human chronic lymphocytic leukemia (CLL) patients express the TCL1 protein, and the overexpression of TCL1 in B cells leads to the development of CLL in mice.

Among the early germ cell markers examined, VASA is a candidate gene for detecting pre-meiotic germ cell differentiation from monkey ES cells, because its expression is detected earlier in the primordial stage of germ cell development in comparison to that of PIWI family genes in vivo in mice and humans [11], [36]--[38], [49].

«That is significant because mice and humans that lack or have substantial defects in regulatory T cells develop lethal autoimmune disease,» Vignali said.